ACE inhibitor cough resolution

What can I do to help a patient's ACE inhibitor cough resolve more quickly? Benzonatate (Tessalon), dextromethorphan (Delsym) cough syrup, and hydrocodone and chlorpheniramine (Tussionex) have provided minimal relief.
— MARCY MORROW, MPAS, PA-C, Gooding, Idaho

Most ACE inhibitor-induced coughs will resolve promptly with cessation of the offending medication, but the literature suggests that in some cases, these coughs can persist for weeks—even after medication has been stopped. Trying a nonspecific antitussive is a good idea. If that strategy does not work, consider indomethacin, baclofen (Kemstro), aspirin, or sulindac (Clinoril). For additional information, see Kaplan NM and Rose BD. Major side effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers. In: Rose BD, ed. UpToDate. UpToDate Web site. www.uptodate.com. Accessed September 16, 2009.
—Reuben Zimmerman, RPA-C
(132-6)

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