Clostridium difficile diarrhea

Do we know which antibiotics are most likely to cause Clostridium difficile diarrhea? Also, what is the correct pronunciation of “difficile?”
—James Nahlik, MD, St. Louis

Any antibiotic can cause C. difficile-associated diarrhea, but the most common are penicillins, clindamycin, cephalosporins, and more recently quinolones.

I use the common U.S. pronunciation “dif-i-seal,” which is the French version. However, the word actually comes from the Latin, so the correct pronunciation would be “dif-ISS-il-ee.” An easy out is to just say “C. diff.” People will know what you mean.
—Christina M. Surawicz, MD (110-19)

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