Coagulopathy in patients with renal disease

Do patients with renal disease have inherent coagulopathy? What prothrombin time (PT)/partial thromboplastin time (PTT) values can be expected with end-stage renal disease (ESRD)?

Patients with ESRD become anemic due to lost erythropoietin production. These patients may also have abnormal platelet function, which can result in bleeding. However, the PT and PTT are usually normal. Coagulation factors are more likely to be affected in liver disease. In renal disease, bleeding time is a more appropriate measure of hemostatic function.
—Claire Babcock O'Connell, MPH, PA-C

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