CRP vs. LDL as a stroke predictor
—Alberto Abreu, MD, Utuado, P.R.
Dr. Abreu brings up two important points. The first—that CRP levels may be a better predictor of MI and strokes than LDL levels alone, especially when there is a lack of concurrence between the two (elevated LDL with normal CRP and vice versa)—is borne out by studies in the literature measuring CRP and LDL levels after statin therapy (N Engl J Med. 2005;352:20-28). The second point relates to comparative efficacy of statins. Rosuvastatin and simvastatin are excellent agents, but the data on atorvastatin are equally impressive and emphasize the importance of all the statins (and to some degree the ACE inhibitors) as anti-inflammatory agents—hence the reduction in CRP and benefits for prognosis (J Am Coll Cardiol. 2005;46:1425-1433).
—Peter F. Cohn, MD (122-11)