Recently a patient asked about microdose therapy for arthritis, but I was unfamiliar with the term. Can you help?
—Jerome J. Kastrul, MD, Glendale, Ariz.
The patient may mean minidose therapy—commonly used with prednisone to minimize side effects. Prednisone (1-4 mg) is utilized, especially for osteoarthritis when use of nonsteroidal anti-inflammatory drugs would be difficult, as in renal insufficiency. I prefer divided-dose therapy, such as 2 mg b.i.d.
—Jack Waxman, MD (111-6)