Biomarker may ID gestational diabetes risk

Share this article:
Biomarker may ID gestational diabetes risk
Biomarker may ID gestational diabetes risk

HealthDay News -- Glycosylated fibronectin may be able to identify first-trimester pregnant women who are at risk for developing gestational diabetes, researchers found.

Above a threshold of 120 mg/L, glycosylated fibronectin levels had a 63% positive predictive value, correctly identifying 57 of 90 pregnant women who developed diabetes at 5 to 13 weeks gestation (95% CI: 53%-72%) and a 95% negative predictive value (95% CI: 94%-95%), Juha P. Rasanen, MD, PhD, of Oregon Health and Science University in Portland, and colleagues reported in Obstetrics & Gynecology.

To evaluate whether certain biomarkers have the potential to identify pregnant women in the first trimester who are at risk for developing gestational diabetes later, the researchers compared serum concentrations of glycosylated fibronectin, adiponectin, sex hormone-binding globulin, placental lactogen and high sensitivity C-reactive protein among 90 pregnant women who developed diabetes at 5 to 13 weeks gestation and 92 control participants.

The researchers observed a significant association between gestational diabetes and  first-trimester serum concentrations for all of the potential biomarkers; however, glycosylated fibronectin was the only serum identified that remained independently associated with developing gestational diabetes after the researchers adjusted for maternal factors and other markers (P<.001).

"First-trimester glycosylated fibronectin is a potential pregnancy-specific biomarker for early identification of women at risk for gestational diabetes," the researchers wrote.

Several authors disclosed financial ties to DiabetOmics, which funded the study.


References

  1. Rasanen JP et al. Obstetrics & Gynecology. 2013; doi: 10.1097/AOG.0b013e3182a0c88b.
Share this article:
You must be a registered member of Clinical Advisor to post a comment.
close

Next Article in Web Exclusives

More in Web Exclusives

High milk intake associated with increased mortality risk

High milk intake associated with increased mortality risk

The risk of any bone fracture increased 16% in women who drank three or more glasses daily, and the risk of a broken hip increased 60%.

DHEA serum levels predict coronary heart disease risk

DHEA serum levels predict coronary heart disease risk

For elderly men, low serum levels of the adrenal sex hormone DHEA and its sulfate, DHEA-S, predict coronary heart disease risk.

Prenatal exposure to sodium valproate linked to lower IQ in offspring

Prenatal exposure to sodium valproate linked to lower ...

The IQ of children exposed to VPA was lower compared with children born to women without epilepsy and that of those exposed to carbamazepine.