Drug Name:
Bumetanide Inj Rx
Generic Name and Formulations:
Bumetanide 0.25mg/mL; contains benzyl alcohol.
Company:
Various generic manufacturers
Therapeutic Use:
Indications for Bumetanide Inj:
Edema.
Adult:
Initially 0.5–1mg IM or IV. May give 1–2 more doses at 2–3 hour intervals; max 10mg/day.
Children:
<18yrs: not recommended.
Contraindications:
Anuria. Infants. Hepatic coma. Severe electrolyte depletion.
Warnings/Precautions:
Hepatic cirrhosis. Ascites. Progressive renal disease. Gout. Diabetes. Postsympathectomy. Monitor electrolytes, blood, liver function. May need K+ supplementation. K+ losing nephropathy. Discontinue if renal dysfunction progresses. Aldosterone excess. Ventricular arrhythmias. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Interactions:
May increase digitalis, lithium toxicity. Hypokalemia with digitalis, diuretics in CHF. Alcohol, CNS depressants increase orthostatic hypotension. Avoid probenecid, indomethacin. Ototoxicity may be potentiated with aminoglycosides.
Pharmacological Class:
Diuretic (loop).
Adverse Reactions:
Muscle cramps, dizziness, hypotension, headache, nausea, encephalopathy, ototoxicity, rash, fluid or electrolyte imbalance, hyperglycemia, hyperuricemia, blood dyscrasias.
Note:
Formerly known under the brand name Bumex.
How Supplied:
Contact supplier.
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