Cholesterol

Statin and PCSK9 inhibitor combination more effective at lowering cholesterol

Statin and PCSK9 inhibitor combination more effective at lowering cholesterol

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PCSK9 inhibition produces incremental benefits on coronary disease progression in patients treated with statins.

Vitamin D may not improve glucose measures in patients at risk for diabetes

Vitamin D may not improve glucose measures in patients at risk for diabetes

Researchers observed significant improvement in LDL cholesterol in those at risk for diabetes.

Statin-based therapy less effective in advanced chronic kidney disease

Statin-based therapy less effective in advanced chronic kidney disease

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Statin-based therapy had a smaller effect in reducing major vascular events in patients with advanced chronic kidney disease.

Alternative non-statin therapies effectively lower LDL cholesterol

Alternative non-statin therapies effectively lower LDL cholesterol

Researchers found that dietary changes, other medications, and surgery can also lower cardiovascular risk.

Lipid screening in children, adolescents: USPSTF recommendation statement

Lipid screening in children, adolescents: USPSTF recommendation statement

Current evidence is insufficient to weigh the balance of benefits and harms of screening.

AAP guidelines recommend screening children for high cholesterol, depression, HIV

AAP guidelines recommend screening children for high cholesterol, depression, HIV

To combat the stigma associated with selective screening, the American Academy of Pediatrics has called for all children to be screened for high cholesterol, depression, and HIV.

Few adults taking necessary cholesterol-lowering medications

Few adults taking necessary cholesterol-lowering medications

A CDC team analyzed national data from 2005 through 2014 and discovered that 35% of Americans eligible to take cholesterol-lowering medication were not taking the drugs.

FDA approves second nonstatin drug to treat patients with high cholesterol

FDA approves second nonstatin drug to treat patients with high cholesterol

The drug is approved for patients who are unable to control their LDL cholesterol with current treatment options.

Newer cholesterol guidelines better at identifying increased risk of CVD events

Newer cholesterol guidelines better at identifying increased risk of CVD events

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The 2013 ACC/AHA cholesterol management guidelines better identify the risk of CVD and presence of coronary artery disease.

FDA approves PCSK9 inhibitor for high cholesterol

FDA approves PCSK9 inhibitor for high cholesterol

The FDA approved Praluent (alirocumab), the first injectable PCSK9 inhibitor for high cholesterol.

Obesity prevention programs influence kids' lipids levels

Obesity prevention programs influence kids' lipids levels

Adiposity and lipid outcomes improved in 15% of obesity prevention programs aimed at children.

Metabolic benefits of fenofibrate greater for women

Metabolic benefits of fenofibrate greater for women

Lipoprotein improvements from fenofibrate greater for women than men; CVD event reduction similar.

Statin efficacy varies widely from patient to patient

Statin efficacy varies widely from patient to patient

More than 40% of those taking high-dose statins don't reach LDL-C target of <70 mg/dL

Patients may not need to fast for cholesterol tests

Patients may not need to fast for cholesterol tests

Agencies should consider re-evaluating the recommendation that patients fast before obtaining a lipid panel.

Niacin, laropiprant may not decrease vascular risk

Niacin, laropiprant may not decrease vascular risk

Adverse effects have been found in 34.2% and 32.5% of patients prescribed extended-release niacin.

High cholesterol may spell low fertility

High cholesterol may spell low fertility

The longest time to achieve pregnancy occurred in couples in which both partners had high cholesterol levels.

Lowering cholesterol may not benefit CKD patients

Lowering cholesterol may not benefit CKD patients

Research suggests that lowering LDL has a non-significant impact on end-stage renal disease.

Merck recalls cholesterol drug Liptruzet

Merck recalls cholesterol drug Liptruzet

Company issues recall due to defects in product packaging

Docs questioning new statin guidelines

Docs questioning new statin guidelines

New cholesterol risk calculator may overestimate heart disease risk.

New cholesterol guidelines drop specific targets

New cholesterol guidelines drop specific targets

Four major statin benefit groups identified for whom benefits outweigh risk of adverse events.

Ranbaxy recalls generic Lipitor

Ranbaxy recalls generic Lipitor

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Drug manufacturer recalls 41 lots of atorvastatin calcium tablets due to potential contamination with small glass particles.

Fasting before lipid tests not necessary

Fasting before lipid tests not necessary

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Few statistically significant differences in cholesterol subclass levels were observed among patients who fasted for various lengths of time.

The effects of exercise on LDL

The effects of exercise on LDL

As LDL goals become more aggressive, therapeutic lifestyle changes are increasingly important in achieving recommended lipid levels.

U.S. lipid profiles improve over past two decades

U.S. lipid profiles improve over past two decades

Cholesterol levels and related lipids among U.S. adults have dropped steadily from 1988 to 2010.

Plumbing for atherosclerosis

Using plumbing as an analogy for atherosclerosis can help improve treatment adherence.

Waistline may help predict cardiovascular risk in teens

Waistline may help predict cardiovascular risk in teens

Increased weight-to-height ratio was associated with worse lipid profiles and hypertension in adolescents.

FDA adds drug interaction warnings to Lipitor, Crestor and Zocor

Drug interactions between statins and certain protease inhibitors for HIV or hepatitis C can increase the risk for myopathy, including rhabdomyolysis.

Change in fitness or fatness influences cardio risk factors

Change in fitness or fatness influences cardio risk factors

Positive change in fitness or fatness can reduce the risk for cholesterol, hypertension and metabolic syndrome.

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