Generic Name and Formulations:
Isosorbide dinitrate 40mg; sust-rel caps.
Indications for DILATRATE-SR:
Prophylaxis and treatment of angina. Not for acute attacks.
See full labeling. Allow at least an 18-hour interval daily between doses to avoid development of tolerance. Max 160mg/day.
Concomitant PDE inhibitors (eg, sildenafil, tadalafil, vardenafil, avanafil) or riociguat.
Recent MI. CHF. Volume depletion. Hypotension. Hypertrophic cardiomyopathy. Monitor standing blood pressure when increasing doses. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers.
See Contraindications. Hypotension potentiated with alcohol, other vasodilators.
Headache, transient lightheadedness, orthostatic hypotension; rare: syncope, angina, rebound hypertension.