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DORYX MPC
Acne
Bacterial infections
Malaria
Protozoal infections
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Drug Name:

DORYX MPC Rx

Generic Name and Formulations:
Doxycycline (as hyclate) 120mg; del-rel tabs; contains sodium.

Company:
Mayne Pharma US

Therapeutic Use:

Indications for DORYX MPC:

Adjunct in severe acne.

Adult:

Swallow whole. Take with fluids; may give with food or milk if gastric irritation occurs. 120mg every 12hrs for 1 day, then 120mg daily (as a single dose or 60mg every 12hrs).

Children:

≤8yrs: not usually recommended. Swallow whole. Take with fluids; may give with food or milk if gastric irritation occurs. >8yrs (<45kg): 5.3mg/kg in 2 divided doses for 1 day, then 2.6mg/kg daily (as a single dose or divided as 2 doses); (≥45kg): use Adults dose.

Warnings/Precautions:

Do not substitute on a mg-per-mg basis with other oral doxycyclines. Discontinue if severe skin reactions, superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Monitor blood, renal, and hepatic function in long-term use. Avoid sun or UV light. Children ≤8yrs: weigh benefits vs risks; reserve use only for severe or life-threatening conditions (eg, anthrax, Rocky Mountain spotted fever) when no alternative therapies exist. Pregnancy. Nursing mothers.

Interactions:

Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium, bismuth subsalicylate, iron. May be antagonized by barbiturates, carbamazepine, phenytoin. May antagonize oral contraceptives. May interfere with fluorescence test.

Pharmacological Class:

Tetracycline antibiotic.

Adverse Reactions:

Anorexia, nausea, vomiting, diarrhea, rash (may be severe), photosensitivity, urticaria, hemolytic anemia; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, increased BUN.

Generic Availability:

NO

How Supplied:

Tabs—60

Indications for DORYX MPC:

Tetracycline-susceptible infections including respiratory, genitourinary, rickettsial, trachoma, specific bacterial (eg, relapsing fever). Alternative for selected infections when penicillin is contraindicated. Anthrax including inhalational anthrax (postexposure).

Adult:

Swallow whole. Take with fluids; may give with food or milk if gastric irritation occurs. 120mg every 12hrs for 1 day; then 120mg daily (as a single dose or 60mg every 12hrs); if severe infections (eg, chronic UTI): 120mg every 12hrs. Streptococcal infections: treat for 10 days. Uncomplicated urethral, endocervical, rectal infection, or nongonococcal urethritis (NGU): 120mg twice daily for 7 days. Uncomplicated gonococcal infections (except anorectal infections in men): 120mg twice daily for 7 days or 360mg as single dose followed by a second 360mg dose 1hr later. Acute epididymo-orchitis: 120mg twice daily for at least 10 days. Syphilis (allergic to penicillin): Early: 120mg twice daily for 2 weeks; >1yr duration: treat for 4 weeks. Anthrax: 120mg twice daily for 60 days.

Children:

≤8yrs: not usually recommended. Swallow whole. Take with fluids; may give with food or milk if gastric irritation occurs. >8yrs (<45kg): 5.3mg/kg in 2 divided doses for 1 day, then 2.6mg/kg daily (as a single dose or divided as 2 doses); if severe infections: 2.6mg/kg every 12hrs; (≥45kg): use Adults dose. Anthrax (<45kg): 2.6mg/kg twice daily for 60 days; (≥45kg): use Adults dose.

Warnings/Precautions:

Do not substitute on a mg-per-mg basis with other oral doxycyclines. Discontinue if severe skin reactions, superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Monitor blood, renal, and hepatic function in long-term use. Avoid sun or UV light. Children ≤8yrs: weigh benefits vs risks; reserve use only for severe or life-threatening conditions (eg, anthrax, Rocky Mountain spotted fever) when no alternative therapies exist. Pregnancy. Nursing mothers.

Interactions:

Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium, bismuth subsalicylate, iron. May be antagonized by barbiturates, carbamazepine, phenytoin. May antagonize oral contraceptives. May interfere with fluorescence test.

Pharmacological Class:

Tetracycline antibiotic.

Adverse Reactions:

Anorexia, nausea, vomiting, diarrhea, rash (may be severe), photosensitivity, urticaria, hemolytic anemia; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, increased BUN.

Generic Availability:

NO

How Supplied:

Tabs—60

Indications for DORYX MPC:

Short term prophylaxis of malaria due to P. falciparum.

Adult:

Swallow whole. Take with fluids; may give with food or milk if gastric irritation occurs. Begin 1–2 days before travel to the malarious area, continue during and 4 weeks after leaving the area. 120mg daily.

Children:

<8yrs: not recommended. Swallow whole. Take with fluids; may give with food or milk if gastric irritation occurs. Begin 1–2 days before travel to the malarious area, continue during and 4 weeks after leaving the area. ≥8yrs (<45kg): 2.4mg/kg once daily; (≥45kg): use Adults dose.

Warnings/Precautions:

Do not substitute on a mg-per-mg basis with other oral doxycyclines. Discontinue if severe skin reactions, superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Monitor blood, renal, and hepatic function in long-term use. Avoid sun or UV light. Children ≤8yrs: weigh benefits vs risks; reserve use only for severe or life-threatening conditions (eg, anthrax, Rocky Mountain spotted fever) when no alternative therapies exist. Pregnancy. Nursing mothers.

Interactions:

Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium, bismuth subsalicylate, iron. May be antagonized by barbiturates, carbamazepine, phenytoin. May antagonize oral contraceptives. May interfere with fluorescence test.

Pharmacological Class:

Tetracycline antibiotic.

Adverse Reactions:

Anorexia, nausea, vomiting, diarrhea, rash (may be severe), photosensitivity, urticaria, hemolytic anemia; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, increased BUN.

Generic Availability:

NO

How Supplied:

Tabs—60

Indications for DORYX MPC:

Adjunct in acute intestinal amebiasis.

Adult:

Swallow whole. Take with fluids; may give with food or milk if gastric irritation occurs. 120mg every 12hrs for 1 day, then 120mg daily (as a single dose or 60mg every 12hrs).

Children:

≤8yrs: not usually recommended. Swallow whole. Take with fluids; may give with food or milk if gastric irritation occurs. >8yrs (<45kg): 5.3mg/kg in 2 divided doses for 1 day, then 2.6mg/kg daily (as a single dose or divided as 2 doses); (≥45kg): use Adults dose.

Warnings/Precautions:

Do not substitute on a mg-per-mg basis with other oral doxycyclines. Discontinue if severe skin reactions, superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Monitor blood, renal, and hepatic function in long-term use. Avoid sun or UV light. Children ≤8yrs: weigh benefits vs risks; reserve use only for severe or life-threatening conditions (eg, anthrax, Rocky Mountain spotted fever) when no alternative therapies exist. Pregnancy. Nursing mothers.

Interactions:

Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium, bismuth subsalicylate, iron. May be antagonized by barbiturates, carbamazepine, phenytoin. May antagonize oral contraceptives. May interfere with fluorescence test.

Pharmacological Class:

Tetracycline antibiotic.

Adverse Reactions:

Anorexia, nausea, vomiting, diarrhea, rash (may be severe), photosensitivity, urticaria, hemolytic anemia; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, increased BUN.

Generic Availability:

NO

How Supplied:

Tabs—60

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