Drug Reactions

Ovarian Cancer Risk Reduced With Regular, Low-Dose Aspirin

Ovarian Cancer Risk Reduced With Regular, Low-Dose Aspirin

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Although ovarian cancer risk may be reduced with regular use of low-dose aspirin, the use of nonaspirin analgesics may increase the risk of ovarian cancer among long-term, high-quantity users.

FDA: Cases of Rare Gangrene of Genital Area Tied to Diabetes Drug Class

FDA: Cases of Rare Gangrene of Genital Area Tied to Diabetes Drug Class

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The infection developed within several months of the patients starting SGLT2 therapy and the drug was discontinued in most cases. All patients required surgery and there was 1 reported death.

Long-Term PPI Use Linked to Pneumonia Risk in Older Adults

Long-Term PPI Use Linked to Pneumonia Risk in Older Adults

Rate of incident pneumonia increased in second year after initiating treatment with proton pump inhibitors.

FDA Rejects Treatment for Uterine Fibroids Based on Safety Concerns

FDA Rejects Treatment for Uterine Fibroids Based on Safety Concerns

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The NDA included data from two Phase 3 clinical trials (VENUS I and VENUS II), all four Phase 3 European Union registration studies, and real-world data of >700,000 women with uterine fibroids across 80 countries.

Antidepressants and Bleeding Risk: What's the Link?

Antidepressants and Bleeding Risk: What's the Link?

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Results showed an increased risk of bleeding with SRIs by 1.16-2.36 times with an even higher 3.17- to 10.9-fold risk with concomitant NSAIDs.

Stat Consult: Cleft Lip and Palate

Stat Consult: Cleft Lip and Palate

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Cleft lip and palate is defined as congenital malformation of the upper lip and/or oral cavity disrupting normal facial structure and oromotor function.

Heat-Stable Carbetocin Safe Alternative to Oxytocin for Postpartum Hemorrhage Prevention

Heat-Stable Carbetocin Safe Alternative to Oxytocin for Postpartum Hemorrhage Prevention

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Heat-stable carbetocin — an analog of oxytocin — was found to be noninferior to oxytocin in preventing hemorrhage associated with vaginal birth and may be beneficial in low- and middle-income countries.

Congenital Anomalies Not Linked to Metformin Use After First Trimester

Congenital Anomalies Not Linked to Metformin Use After First Trimester

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Metformin use during the first trimester of pregnancy is not correlated with an increased risk of congenital anomalies.

Efavirenz Does Not Increase Depression, Suicidal Ideation in HIV-Infected

Efavirenz Does Not Increase Depression, Suicidal Ideation in HIV-Infected

No increased risk of depression or suicidal ideation among persons living with HIV in Uganda.

Prenatal antidepressant exposure may increase risk of poor motor development

A meta-analysis of 18 studies examining the association of prenatal antidepressant exposure with motor development in children showed a small overall effect of worse motor development outcomes among children exposed to antidepressants in pregnancy.

Medications with depression as a possible adverse effect associated with increased depression risk

In this cross-sectional study, the use of medications with depression as an adverse effect was associated with a higher prevalence of depression while a similar association was not observed for medications without depression as a possible side effect.

Long-Term Antidepressant Use Linked to Weight Gain

Long-Term Antidepressant Use Linked to Weight Gain

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The broad use of antidepressants among the general population may be linked to weight gain.

Severe Folate Deficiency Associated With Olaparib for Relapsed Ovarian Cancer

Severe Folate Deficiency Associated With Olaparib for Relapsed Ovarian Cancer

In a case study, olaparib was found to induce folate deficiency in most patients with relapsed ovarian cancer. Researchers discuss the significance of this adverse effect and how it was managed.

FDA: Possible Risk of Neural Tube Birth Defects With Certain HIV Meds

FDA: Possible Risk of Neural Tube Birth Defects With Certain HIV Meds

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The Agency has received reports of serious neural tube birth defects involving the brain, spine, and spinal cord in babies born to women who received dolutegravir for HIV treatment.

Oral Anticoagulation: Reversing the Current View in Bleeding Events

Oral Anticoagulation: Reversing the Current View in Bleeding Events

Advances in new reversal agents will be key for managing patients treated with DOACs to prevent major bleeding events.

Solanezumab does not change cognitive decline in mild Alzheimer’s disease

In patients with mild Alzheimer's disease solanezumab, an antibody designed to facilitate clearance of amyloid-beta plaques, did not significantly reduce cognitive decline over time.

Antithrombotic drug use linked to higher risk of subdural hematoma

Antithrombotic drug use linked to higher risk of subdural hematoma

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A higher incidence of subdural hematomas is associated with the increased use of antithrombotic drugs, particularly vitamin k antagonists among older patients.

Cannabis health risks and benefits: a report from NASEM

Cannabis health risks and benefits: a report from NASEM

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Cannabis health end points include therapeutic effects, cardiometabolic risk, mental health, respiratory disease, and substance abuse.

"Zombie" outbreak in New York City caused by ultrapotent cannabinoid use

"Zombie" outbreak in New York City caused by ultrapotent cannabinoid use

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The potency of synthetic cannabinoids is consistent with strong depressant effects that account for "zombie-like" behavior.

Grapefruit-drug interactions


Grapefruit-drug interactions


Grapefruit can safely be consumed with the majority of medications, and patients with concerns should consult with their physicians.

Exploring the lidocaine with epinephrine myth

Exploring the lidocaine with epinephrine myth

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Research suggests that injecting lidocaine with epinephrine may not be as dangerous as previously thought.

Otitis treatment in a child with suspected penicillin allergy

Otitis treatment in a child with suspected penicillin allergy

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A patient was diagnosed with a serum sickness-like reaction in response to antibiotics.

NY patient awarded $120 million in malpractice lawsuit

NY patient awarded $120 million in malpractice lawsuit

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A Bronx jury awarded close to $120 million to a woman who suffered brain damage after being treated at three New York area hospitals.

Hepatitis C therapy interferes with HIV treatment

Taking boceprevir with ritonavir-boosted HIV protease inhibitors together reduces the effectiveness of both therapies, the FDA announced.

What causes a metallic taste and burning tongue?

What are the differential diagnoses for a woman aged 60 years with a metallic taste in her mouth and the sensation of a burning tongue?

Is this rash related to terbinafine?

A patient taking terbinafine for onychogryphosis developed a fine pruritic rash over sun exposed body areas while on vacation. Could the drug be to blame?

A spoonful of sugar helps students visualize the metric system

A spoonful of sugar helps students visualize the metric system

Read this tip for making abstract concepts, like converting metric medication doses, go down smoothly.

Risk for new infections with TNF blockers reported

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The FDA is updating boxed warnings on all tumor necrosis factor-alpha inhibiting drugs to reflect risk for infection with the bacteria Legionella and Listeria.

Antipsychotic causes severe allergic reactions

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The FDA is warning health care providers about reports of type 1 hypersensitivity reactions among patients taking the antipsychotic asenapine maleate (Saphris), with some cases occurring at first dose.

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