Generic Name and Formulations:
Ethacrynic acid 25mg; scored tabs.
Valeant Pharmaceuticals, Inc
Indications for EDECRIN:
Treatment of edema when greater diuretic potential is required.
Initially 50–100mg daily; adjust in 25–50mg increments. Usual maintenance: 50–200mg daily or intermittently.
See Contraindications. Initially 25mg; adjust gradually in 25mg increments (see literature).
Anuria. Infants. If severe, watery diarrhea occurs, discontinue use and do not restart.
Renal impairment. Hepatic cirrhosis. Monitor weight, renal function, electrolytes, CO2, BUN. Potassium supplementation may be needed. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.
Digitalis, lithium toxicity. May alter excretion of lithium. Potentiates warfarin. Antagonized by NSAIDs. Orthostatic hypotension with antihypertensives. Ototoxicity with aminoglycosides, other ototoxic agents. May alter glucose tolerance tests.
GI upset, anorexia, malaise, abdominal pain, dysphagia, ototoxicity, vertigo, headache, rash, electrolyte imbalance, hyperuricemia, gout, hyperglycemia; rare: agranulocytosis, severe neutropenia, thrombocytopenia.