Gastroenterology Information Center Archive

Short-term probiotics linked to lower fat percentage in overweight, obese patients

The meta-analysis showed that short-term probiotic supplementation reduced body weight, BMI, and fat percentage, but the effect sizes were small.

Dabigatran, rivaroxaban associated with increased risk of major gastrointestinal bleeding

The data suggest possible variability across NOACs regarding gastrointestinal bleeding risk, with an increased risk associated with rivaroxaban and dabigatran.

Gastroesophageal adenocarcinoma patients benefit from adjuvant chemotherapy

The researchers found that patients receiving adjuvant chemotherapy for gastroesophageal adenocarcinoma were younger, more likely to have advanced disease, and had shorter postoperative inpatient stays.

Physical and psychological coping skills associated with symptom severity in IBS

The association is partially mediated by levels of anxiety and depressive symptoms.

Colonoscopy rates improve from patient navigators, provider reminders

Patient-level interventions include changes to invitation, giving results or follow-up appointments, and patient navigators, and provider-level interventions include reminders or performance data.

Gastric bypass surgery effective for weight loss, diabetes prevention for 12 years

The 12-year results show that Roux-en-Y gastric bypass offered long-term durability of weight loss and was associated with fewer obesity-related coexisting conditions compared with those who did not have the surgery.

Pediatric inflammatory bowel disease increases cancer risk in adulthood

Patients with childhood-onset IBD have an increased risk of cancer, especially gastrointestinal cancers, lymphoid neoplasms, and skin cancer,

Colon cleansing regimens in inflammatory bowel disease: a review

A PEG low-volume regimen is similar to a PEG high-volume regimen for colon cleansing in patients with IBS.

GERD may be associated with long-term risk of pneumonia

Incidence of pneumonia was higher among patients with GERD compared with matched controls.

Clinical pathway beneficial for pediatric acute gastroenteritis

Clinical pathway to improve care of acute gastroenteritis patients is associated with a sustained reduction in IV fluid use and length of stay in the pediatric emergency department.

Asthma associated with later development of inflammatory bowel disease

Asthma was associated with Crohn's disease and with early- and late-onset ulcerative colitis.

Colorectal cancer mortality rates increasing in younger white adults

Researchers analyzed colorectal cancer mortality rates among individuals between 20 and 54 years of age from 1970 through 2014.

Adding oats to a gluten-free diet may not affect patients with celiac disease

The addition of oats to a gluten-free diet did not affect symptoms, histology, immunity, or serologic features in patients with celiac disease.

Inflammatory bowel disease less likely in children and teens from rural areas

Environmental risk factors that predispose people to inflammatory bowel disease may have a stronger effect in children than adults.

Financial incentive linked to increased colonoscopy rates

Researchers found that a cash incentive of $100 was associated with increased colorectal screening rates in eligible adults.

Adverse events common in hospitalized patients taking antibiotics

Many adverse events could be avoidable with more judicious use of antibiotics.

Antibody screenings could detect celiac disease in asymptomatic children

Serum TG2A screening has a positive predictive value of 61% to detect celiac disease.

Increased adenoma detection rate associated with lower risk of colorectal cancer and death

An increased ADR is associated with an adjusted hazard ratio of 0.63 for interval colorectal cancer and 0.50 for cancer death.

Immune profile differs during symptom flare for patients with irritable bowel syndrome

Interferon- concentrations and THELPER cells are significantly reduced during symptom flares.

Proton pump inhibitor use associated with excess risk of death

Risk of death is increased among those without gastrointestinal conditions and with prolonged use.

Risk-scoring model predicts advanced colorectal neoplasia in younger adults

The score could help predict advanced colorectal neoplasia in adults younger than 50 years of age.

Endoscopy's role in primary sclerosing cholangitis: a clinical guideline

The guideline is intended to be an educational device to provide information that may assist endoscopists in providing care to patients.

Breast milk bacteria seed development of infant gut microbiome

Findings show that bacteria from mothers' breast milk and areolar skin are transferred to their infants' guts.

FDA approves medical device to treat esophageal atresia

The new device uses magnetic catheters to draw the upper and lower esophagus together.

Elemental diet restores esophageal mucosal integrity in eosinophilic esophagitis

However, duodenal integrity appears to not be affected in eosinophilic esophagitis.

Gluten consumption affects symptom onset in functional dyspepsia

Gluten-rich food may lead to symptom onset, specifically early satiety, in patients with functional dyspepsia.

Zinc effective in children with presymptomatic Wilson disease

Treatment was effective in patients under 6 years who received 50 mg/day of zinc as an initial dose.

Side effects may affect medication nonadherence in patients with chronic disease

Almost half of participants reported that they never received information regarding the side effects of their medication from their prescriber.

Long-term gluten consumption not linked to coronary heart disease

Avoiding gluten may result in reduced consumption of beneficial whole grains that could affect cardiovascular risk.

Colonoscopy timing after positive fecal test linked to colorectal cancer risk

A follow-up colonoscopy more than 10 months after a positive FIT result is associated with a higher risk of colorectal cancer and more advanced disease at the time of diagnosis.

Long-term antibiotic use associated with an increased risk of colorectal adenoma

Increasing duration of antibiotic use at ages 20 to 39 and 40 to 59 is significantly associated with an increased risk of colorectal adenoma.

Apixaban linked to lower risk of gastrointestinal bleeding

Apixaban is associated with a lower risk of gastrointestinal bleeding than rivaroxaban or dabigatran.

Celiac disease linked to diagnosis of anorexia nervosa

Celiac disease is associated with anorexia nervosa before and after a diagnosis of celiac disease.

FDA approves first direct-to-consumer genetic health risk test

The test will provide information on an individual's genetic predisposition to 10 diseases or conditions.

Screening for celiac disease: A USPSTF recommendation statement

The USPSTF evaluated the benefits and harms of screening vs not screening, targeted vs universal screening, and treatment for celiac disease.

Gastric acid suppressants may increase risk of recurrent Clostridium difficile infection

A meta-analysis suggests that patients who take gastric acid suppressants may have a higher risk for recurrent CDI.

Predicting high healthcare costs in patients with inflammatory bowel disease

Researchers identified 5 factors that identify patients with IBD at high risk for hospitalization, emergency department visits, and high treatment charges in the next year.

Colorectal cancer characteristics different, outcomes worse among octogenarians

Octogenarians with colorectal cancer have several differences in clinical and tumor characteristics, compared with younger patients with the disease.

Budesonide oral suspension may be effective for eosinophilic esophagitis

Budesonide oral suspension treatment improved symptomatic, endoscopic, and histologic parameters in eosinophilic esophagitis.

Irritable bowel syndrome medication linked to pancreatitis in certain patients

The FDA has received 120 reports of serious cases of pancreatitis or death after the approval of Viberzi in May 2015.

Additional weight may affect risk of gastrointestinal cancers

Excess weight could influence the risk of of gastrointestinal cancers by altering insulin levels and promoting inflammation.

FODMAP diet effective for irritable bowel syndrome

Implementation of the FODMAP diet is an effective strategy to manage symptoms of IBS, including bloating and abdominal pain.

Gluten challenge not effective for confirming non-celiac gluten sensitivity

Thirty-eight of 231 NCGS patients showed gluten-specific symptoms when completing the placebo-controlled gluten challenge.

Gluten-free diet may increase risk of type 2 diabetes

Individuals who consume the least amount of gluten are more likely to develop type 2 diabetes.

Evaluating abnormal liver chemistries: a clinical guideline

The American College of Gastroenterology has released recommendations of preferred approaches for diagnosing and evaluating patients with abnormal liver test results.

Proton pump inhibitor use may decrease healthcare visits in GERD patients

Among GERD patients, the mean annual ARI episode dropped from 4.39 during the year before PPI treatment to 3.89 after treatment with a PPI.

FDA approves Trulance for chronic idiopathic constipation treatment

Trulance has been approved for the treatment of chronic idiopathic constipation in adults.

Endoscopic sleeve gastroplasty results in successful weight loss

The procedure could be used as alternative to bariatric surgery for selected patients with obesity.

HCV patients with diabetes may have increased risk of hepatocellular carcinoma

Diabetes could increase the risk of developing hepatocellular carcinoma in patients with hepatitis C.

Gastrointestinal adverse events increase with GLP-1 receptor agonists

Risk was dependent on dose, background medications, and type of GLP-1 receptor agonist.

Antibiotics associated with reduced mortality rate in cirrhosis patients

Timely administration of antibiotics was associated with a 30% reduction in 30 day mortality.

Liver hepatotoxicity results from herbal, dietary supplements

The ultimate goal should be to more closely regulate potentially injurious ingredients in herbal and dietary supplements.

FDA requires black box warning on HCV drugs regarding potential HBV reactivation

The FDA issues a warning about the risk of hepatitis B virus reactivation among patients taking direct-acting antivirals to treat hepatitis C infections.

Biologic agents may increase infection risk in inflammatory bowel disease

Biologic agents increase the risk of opportunistic infection, but do not increase the risk of serious infection or malignancy.

Exercise reduces lipid content in nonalcoholic fatty liver disease

Physical Activity reduces intrahepatic lipid content and markers of hepatocellular injury in patients with NAFLD and this effect correlated with baseline body mass index.

Patients diagnosed with upper functional gastroenterology disorders often have irritable bowel syndrome

The risk factors for IBS-FD overlap deserve more concern, according to the authors.

Pancreatic cancer is most lethal pancreatic disorder worldwide

The mortality rate from pancreatic cancer is significantly higher in the American region than in the European and Western Pacific regions.

Chronic pancreatitis in women typically not related to alcohol use

Most cases of chronic pancreatitis in women are from nonalcoholic etiologies, according to researchers.

USPSTF recommends screening for colorectal cancer from age 50 to 75

The USPSTF has released a recommendation statement regarding screening adults for colorectal cancer.

A step-by-step approach to managing gastrointestinal bleeding

Using a stepwise approach to diagnose and treat gastrointestinal bleeding can improve patient outcomes.

Keep misconceptions in mind when recommending probiotics

When recommending probiotics to patients, NPs should remember that different strains have different health benefits.

Oral contraceptives increase surgery risk for women with Crohn disease

Women with Crohn disease who use oral contraceptives for more than 1 year have an increased risk of surgery.

FDA warns that misuse of antidiarrheal loperamide can cause severe cardiac events

The FDA warns that the antidiarrheal loperamide can lead to serious cardiac events when taken in high doses.

Greater gluten intake before age 2 may increase risk of celiac disease

High gluten intake during the first 2 years of life was associated with an increased risk of celiac disease during childhood.

Low-dose aspirin regimen may reduce risk of certain cancers

A low-dose aspirin regimen was associated with a 3% lower risk of cancer overall.

Benefit of fiber intake not equal in IBD patients

Patients with Crohn disease who ate high-fiber foods were 40% less likely to have a disease flare.

Constipation: Diagnosis and treatment overview

Strong evidence for efficacy has been established for stimulant and osmotic laxatives, new intestinal secretagogues, and peripherally restricted μ-opiate receptor antagonists, according to a review in JAMA.

PAMORA for opioid-induced constipation

Naloxegol functions as a peripherally acting mu-opioid receptor antagonist in tissues such as the gastrointestinal tract, thereby decreasing the constipating effects of opioids.

Delphi methods can improve gastroenterology, liver workups

Delphi methodology can optimize gastroenterology and hepatology workups.

Colonoscopy prep is more effective with split-dose regimen

The quality of colon cleansing is better with split-dose regimens than with day-before prep.

Antibiotics may be alternative 
to appendectomy in some patients

Patients with uncomplicated appendicitis may be treated with antibiotics instead of surgery.

PPIs linked to heart attack

Adults who took PPIs had a significantly higher risk of heart attack compared with those who didn't.

Gastritis tied to metformin-related gastrointestinal side effects in type 2 diabetes

With metformin, mean score for gastrointestinal side effects higher for gastritis subjects over four weeks.

Anxiety, depression worsen gastroesophageal reflux disease symptoms

Increased levels of anxiety correlated with more severe retrosternal pain and burning among patients with gastroesophageal reflux disease (GERD).

FDA approves two new therapies for irritable bowel syndrome

Two new therapies to treat irritable bowel syndrome, eluxadoline and rifaximin, have been approved by the FDA.

Raw tuna may be to blame in Salmonella outbreak

At least 53 people in nine states have fallen ill, while 10 have been hospitalized, CDC officials report.

CDC: Beware of norovirus in untreated swimming water

Safe hygiene practices can prevent norovirus outbreaks, according to the CDC.

Clostridium difficile infections most prevalent in Northeast

C. difficile costs as much as $4.8 billion in estimated extra health care costs per year.

Fecal transplantation effective treatment for Clostridium difficile infection

In recurrent infections caused by C. difficile, the intervention is successful 85% of the time.

Novel drug combo shows promise in treating hepatitis C

Most of the patients had minor side effects. Nine of them developed serious health issues, but just three were considered related to the treatment.

Certain gut microbes may be linked to obesity risk

More than two dozen of metabolites were highly correlated with diet, and about half the molecules had not previously been linked to obesity risk.

Colorectal cancer screening for seniors often inappropriate

Colorectal cancer screening was higher in 2010 than in 2008 (58.9% versus 53.7%) and correlated with longer life expectancy and younger age.

Long-term aspirin use may lower gastrointestinal cancer risk

The reduced risk was largely due to fewer cases of gastrointestinal cancers, including colon cancer, rectal cancer, and esophageal cancer.

Multidrug-resistant shigellosis spreads through United States

In the United States, most Shigella is already resistant to the antibiotics ampicillin and trimethoprim/sulfamethoxazole.

All-oral simeprevir-sofosbuvir superior to interferon-based treatment for HCV patients with compensated cirrhosis

Patients assigned the interferon-containing regimen had a significantly higher rate of virologic relapse compared with patients given simeprevir and sofosbuvir.

Consuming 3 or more alcoholic drinks per day may increase liver cancer risk

The investigators also found that being overweight or obese boosts the chances of developing liver cancer.

FDA: Avoid amiodarone use in patients prescribed hepatitis C meds

Adding ledipasvir/sofosbuvir or sofosbuvir to amiodarone could cause symptomatic bradycardia, reported the FDA.

Intervention cuts inappropriate PPI prescriptions

Increase in proportion of PPIs discontinued at hospital discharge after intervention implementation.

Growth monitoring may help identify celiac disease in kids

Screening children for five height- and weight-related differences in growth could be an effective means of spotting those with celiac disease.

Recent hepatitis C infections illuminate need for tightened infection control

In both cases, there were breaches in safety rules, CDC reports.

Antiviral treatment improves hepatitis B virus-related hepatocellular carcinoma survival rates

Overall survival was significantly improved for patients treated with nucleoside analogues (NAs) versus those who received no NAs.

First generic esomeprazole approved by FDA

The FDA has approved esomeprazole magnesium delayed-release capsules, the first generic version of AstraZeneca's Nexium.

Unhealthy diet tied to refractory functional dyspepsia

The prevalence of unhealthy dietary behaviors was higher among RFD and NRFD compared with healthy controls.

Statin use poses low risk of hepatic injury in liver disease

There was no difference overall in the incidence with different statins, but high-dose atorvastatin was associated with increased hospitalization.

Earlier life adiposity tied to nonalcoholic fatty liver disease in adolescents

Adiposity at age 3 years has been linked to diagnosis and severity of hepatic steatosis in late adolescence.

Alkaline phosphatase, bilirubin predict outcomes in primary biliary cirrhosis

Levels of alkaline phosphatase that were two times the upper limit of normal at one year after study enrollment best predicted patient outcomes.

New drug combo wins FDA approval to treat UTIs, intra-abdominal infections

Ceftolozane/tazobactam is the fourth antibiotic to be FDA approved in 2014

Fatty acid propionate may prevent weight gain

Colonic propionate may aid in appetite suppression in overweight adult patients.

New guidelines address irritable bowel syndrome drugs

New guidelines for irritable bowel syndrome treatment have been released by the American Gastroenterological Association.

Too little, too much sleep increase ulcerative colitis risk

Patients who slept more or less than the recommended seven to eight hours per night had higher incidence of ulcerative colitis.

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