Gastroesophageal Reflux Disease (GERD)

Proton pump inhibitors linked with increased dementia risk

Proton pump inhibitors linked with increased dementia risk

Both prescription and OTC proton pump inhibitors have been linked to an increased risk for development of dementia.

PPIs linked to heart attack

PPIs linked to heart attack

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Adults who took PPIs had a significantly higher risk of heart attack compared with those who didn't.

Anxiety, depression worsen gastroesophageal reflux disease symptoms

Anxiety, depression worsen gastroesophageal reflux disease symptoms

Increased levels of anxiety correlated with more severe retrosternal pain and burning among patients with gastroesophageal reflux disease (GERD).

Intervention cuts inappropriate PPI prescriptions

Intervention cuts inappropriate PPI prescriptions

Increase in proportion of PPIs discontinued at hospital discharge after intervention implementation.

First generic esomeprazole approved by FDA

First generic esomeprazole approved by FDA

The FDA has approved esomeprazole magnesium delayed-release capsules, the first generic version of AstraZeneca's Nexium.

Gastroesophageal reflux disease may cause short sleep duration

Gastroesophageal reflux disease may cause short sleep duration

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A recent study suggested that GERD may influence sleeping patterns.

Generic Aciphex approved to treat GERD

Generic Aciphex approved to treat GERD

FDA approves first generic versions of Aciphex delayed-release tablets to treat gastroesophageal reflux disease.

PPI ups risks without improving asthma control in kids with GER

PPI ups risks without improving asthma control in kids with GER

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Lansoprazole was associated with higher rates of upper respiratory infection, sore throat and bronchitis and no effect on asthma control.

Clinical evaluation of 
peptic ulcer disease

Clinical evaluation of 
peptic ulcer disease

Most often caused by use of nonsteroidal anti-inflammatory drugs or 
bacterial infection, peptic ulcer disease usually presents as epigastric pain.

Weight loss improves GERD symptoms

Weight loss improves GERD symptoms

Exercise and weight loss viable treatment options in patients with gastroesophageal reflux disease.

Identifying the cause of bilateral ear pain

Identifying the cause of bilateral ear pain

Consider unusual causes of chronic or recurrent ear pain.

Use upper endoscopy wisely

Use upper endoscopy wisely

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Inappropriate endoscopy use generates unnecessary costs and exposes patients to harms without improving outcomes.

New device approved for lingering GERD

New device approved for lingering GERD

The LINX Reflux Management System has been approved to treat people with GERD who continue to have chronic symptoms, despite taking maximum medication and making recommended lifestyle changes.

Helicobacter pylori: Toward effective eradication

Helicobacter pylori: Toward effective eradication

When choosing among the available treatment options, consideration must be given to local prevalence and antibiotic resistance.

FDA warns of C. diff risk with PPIs

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Advise patients who experience watery stool that does not go away, abdominal pain and fever while taking PPIs to seek medical attention immediately.

Helicobacter pylori elimination improves

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Patients with functional dyspepsia reaped significant benefits from Helicobacter pylori eradication.

Treating chronic esophageal reflux

What treatment options are available for chronic esophageal reflux? Is surgery ever preferable to long-term treatment with a proton-pump inhibitor?

Reflux rebound after stopping PPI therapy

What is the likelihood of acid-reflux rebound in a patient stopping a proton-pump inhibitor (PPI) (pantoprazole [Protonix]) after taking the medication for one month or more?

GERD not helpful in esophageal cancer screening

GERD not helpful in esophageal cancer screening

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Medically treated patients with mild or absent GERD symptoms were shown to have significantly higher odds of developing Barret's esophagus and esophageal adenocarcinoma.

Avoiding reflux when stopping PPIs

Can patients be weaned from proton pump inhibitors without causing a reflux flare?

Extended proton pump inhibitor use: Is it safe?

What are the consequences of taking proton pump inhibitors (PPIs) over an extended period of time?

Asthma benefit of GERD drugs too small

Asthma benefit of GERD drugs too small

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Magnitude of proton pump inhibitor therapy unlikely to be of meaningful clinical significance.

Bone risk low with OTC GERD drugs

Bone risk low with OTC GERD drugs

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The FDA has determined that osteoporosis and fracture warnings are not needed on the labels of OTC proton pump inhibitors, which are widely used to combat gastroesophageal reflux disease.

Sertraline for constipation

Is sertraline effective as an off-label treatment for irritable bowel syndrome?

Shortness of breath and chest pain worsened by fruits and vegetables

Shortness of breath and chest pain worsened by fruits and vegetables

What first appeared to be infectious esophagitis ended up being a lifelong diagnosis for a young woman.

Silence surrounding a difficult birth adds insult to injury

Silence surrounding a difficult birth adds insult to injury

Respiratory problems lead to neurologic damage for the child and financial ruin for the family.

PPIs for infants with GERD

Due to the risk of more frequent lower respiratory tract infections associated with lansoprazole, some use a histamine-2 blocker first.

PPIs tied to fracture, Clostridium difficile rates

PPI users face a potential rise in the risks of fractures and bacterial infection.

Treating reflux in an infant

Should PPIs be used?

How long can a patient with GERD take a PPI?

Is there a limit to how long a patient with GERD symptoms can be treated with a proton pump inhibitor?

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