Genetics

Patient Interest Fairly High for Melanoma Genetic Risk Testing

Patient Interest Fairly High for Melanoma Genetic Risk Testing

Reduced interest seen in minority and less educated populations.

Ethics of Genealogy Data Use for Solving Crimes Discussed

Ethics of Genealogy Data Use for Solving Crimes Discussed

Ethical discussion relates to issues of informed consent, privacy, and justice

Genetic Risk Score Better Than APOE Alone for Assessing Risk for Alzheimer's Dementia

Genetic Risk Score Better Than APOE Alone for Assessing Risk for Alzheimer's Dementia

The genetic risk score primarily modified the risk for and onset of dementia and AD among homozygous carriers for APOE ε4.

A History of Race and the Emerging Role of Genetics in Primary Care

A History of Race and the Emerging Role of Genetics in Primary Care

In 2003, the Human Genome Project became the culmination of the history of genetics research, allowing us to understand the role of genetics in human health and disease. As part of The Clinical Advisor's 20th Anniversary, this article explores the influence of race and genetics in clinical practice.

Complete fetal genome sequences can be obtained from amniotic fluid

Complete fetal genome sequences can be obtained from amniotic fluid

Complete genome sequences were elucidated for 31 fetuses from amniotic fluid. Two methods of DNA extraction proved to be relatively equal in quality of complete genome sequence.

Ovarian cancer may be paternally inherited

Ovarian cancer may be paternally inherited

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The disease allele may be passed from affected grandmother to granddaughter through the father's inherited genes.

Genetic testing: an overview for clinicians

Genetic testing: an overview for clinicians

Understanding genetic testing allows providers to make the most of this resource in patient care.

FDA approves first direct-to-consumer genetic health risk test

FDA approves first direct-to-consumer genetic health risk test

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The test will provide information on an individual's genetic predisposition to 10 diseases or conditions.

ACOG issues recommendations for prenatal genetic screening, diagnostic testing

ACOG issues recommendations for prenatal genetic screening, diagnostic testing

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Published practice bulletins offer guidance to clinicians on patient education during pregnancy.

Primary care clinician risk assessment for hereditary breast cancer

Primary care clinician risk assessment for hereditary breast cancer

Primary care clinicians should be proficient at assessing the potential for hereditary breast cancer risk in their patients.

Few women receive genetic counseling prior to BRCA test

Few women receive genetic counseling prior to BRCA test

Women who receive genetic counseling prior to undergoing BRCA testing display more knowledge of both the testing process and of the potential results.

Multigene tests can change breast, ovarian cancer management

Multigene tests can change breast, ovarian cancer management

For hereditary breast, ovarian cancer, multigene testing can influence clinical treatment options.

VNN1 gene may be potential biomarker for childhood asthma

VNN1 gene may be potential biomarker for childhood asthma

The activity of a gene called vanin-1 (VNN1) affected whether they were good or poor responders to corticosteroid treatment.

Researchers make headway on understanding body's response to allergies

Researchers make headway on understanding body's response to allergies

In the absence of Mbd2, dendritic cells display reduced phenotypic activation and a markedly impaired capacity to initiate immunity against helminthes or allergens.

Are shorter people at higher risk for developing coronary artery disease?

Are shorter people at higher risk for developing coronary artery disease?

There is a relative 13.5% increase in coronary artery disease risk for every 2.5 inches shaved off a person's height.

First neonatal SCID screening test approved by FDA

First neonatal SCID screening test approved by FDA

The Food and Drug Administration (FDA) has granted marketing of the EnLite Neonatal TREC Kit, the first FDA-cleared test to screen for severe combined immunodeficiency (SCID) in newborns.

Provide counseling to family after infant tests positive for sickle cell trait

Provide counseling to family after infant tests positive for sickle cell trait

Primary-care providers should offer educational materials and genetic counseling to families of newborns with positive results for sickle cell trait.

Genetically low vitamin D levels may increase early death risk

Genetically low vitamin D levels may increase early death risk

Gene variants linked to vitamin levels didn't affect cardiovascular-related mortality.

Genetic factors affect impact of exercise on type 2 diabetes risk

Genetic factors affect impact of exercise on type 2 diabetes risk

Exercise does not provide its usual benefit against diabetes in patients with high genetic risk for developing type 2 diabetes and insulin resistance.

Genomic test differentiates between psoriasis, eczema

Genomic test differentiates between psoriasis, eczema

The test identified whether all patients in the study had either dermatologic condition correctly.

Drinking less alcohol benefits heart health

Drinking less alcohol benefits heart health

Patients with the rs1229984 gene variant tended to drink less and had healthier hearts.

AP1S3 mutations associated with psoriasis

AP1S3 mutations associated with psoriasis

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AP1S3 variants were present in a significant number of patients with acrodermatitis continua of Hallopeau.

Rare gene linked to type 2 diabetes in Hispanics

Rare gene linked to type 2 diabetes in Hispanics

The p.E508K mutation, found only in Hispanic patients, is associated with increased prevalence of type 2 diabetes.

What to know about home genetic-test kits

What to know about home genetic-test kits

Consumers becoming more involved in do-it-yourself genetic testing need primary-care clinicians to put the results into context for them.

PIM1 gene ID'd as potential therapeutic target in psoriasis

PIM1 gene ID'd as potential therapeutic target in psoriasis

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Researchers are beginning to unravel the functional significance of key gene variants in psoriasis.

New genetic targets IDed for HCV treatment

New genetic targets IDed for HCV treatment

DNA changes on the IFNL3 gene have been associated with better treatment responses and natural ability to clear infection among patients with hepatitis C infection.

Genetics may influence weight gain from fried food

Genetics may influence weight gain from fried food

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Individuals with a greater genetic predisposition to adiposity may be more susceptible to adverse outcomes from fried food consumption.

Genetics may play role in childhood obesity

Genetics may play role in childhood obesity

Genetics may influence how infants respond to food and subsequent obesity risk.

Gene boosts heart risk in type 2 diabetes

Gene boosts heart risk in type 2 diabetes

A variant of a gene associated with glutamic acid metabolism increases heart disease risk in patients with diabetes.

Eating disorders, alcoholism genetically linked

Eating disorders, alcoholism genetically linked

Genes may contribute 38% to 53% of the risk of developing those disorders, researchers estimate.

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