Whole-exome sequencing revealed that PALB2, ATM, CHEK2, and MSH6 genes were significantly associated with an increased risk of breast cancer; MSH6, RAD51C, TP53, and ATM were found to be linked to an increased risk of ovarian cancer.
Expression of KLRD1 by natural killer cells before infection associated with influenza severity.
Before the Affordable Care Act, insurance companies could deny coverage to patients based on genetic testing results.
For cancers associated with numerous copy number changes, it is difficult to assign disease classifiers and identify useful targets for drug development.
Reduced interest seen in minority and less educated populations.
Ethical discussion relates to issues of informed consent, privacy, and justice
The genetic risk score primarily modified the risk for and onset of dementia and AD among homozygous carriers for APOE ε4.
In 2003, the Human Genome Project became the culmination of the history of genetics research, allowing us to understand the role of genetics in human health and disease. As part of The Clinical Advisor's 20th Anniversary, this article explores the influence of race and genetics in clinical practice.
Complete genome sequences were elucidated for 31 fetuses from amniotic fluid. Two methods of DNA extraction proved to be relatively equal in quality of complete genome sequence.
The disease allele may be passed from affected grandmother to granddaughter through the father's inherited genes.
Understanding genetic testing allows providers to make the most of this resource in patient care.
The test will provide information on an individual's genetic predisposition to 10 diseases or conditions.
Published practice bulletins offer guidance to clinicians on patient education during pregnancy.
Primary care clinicians should be proficient at assessing the potential for hereditary breast cancer risk in their patients.
Women who receive genetic counseling prior to undergoing BRCA testing display more knowledge of both the testing process and of the potential results.
For hereditary breast, ovarian cancer, multigene testing can influence clinical treatment options.
The activity of a gene called vanin-1 (VNN1) affected whether they were good or poor responders to corticosteroid treatment.
In the absence of Mbd2, dendritic cells display reduced phenotypic activation and a markedly impaired capacity to initiate immunity against helminthes or allergens.
There is a relative 13.5% increase in coronary artery disease risk for every 2.5 inches shaved off a person's height.
The Food and Drug Administration (FDA) has granted marketing of the EnLite Neonatal TREC Kit, the first FDA-cleared test to screen for severe combined immunodeficiency (SCID) in newborns.
Primary-care providers should offer educational materials and genetic counseling to families of newborns with positive results for sickle cell trait.
Gene variants linked to vitamin levels didn't affect cardiovascular-related mortality.
Exercise does not provide its usual benefit against diabetes in patients with high genetic risk for developing type 2 diabetes and insulin resistance.
The test identified whether all patients in the study had either dermatologic condition correctly.
Patients with the rs1229984 gene variant tended to drink less and had healthier hearts.
AP1S3 variants were present in a significant number of patients with acrodermatitis continua of Hallopeau.
The p.E508K mutation, found only in Hispanic patients, is associated with increased prevalence of type 2 diabetes.
Consumers becoming more involved in do-it-yourself genetic testing need primary-care clinicians to put the results into context for them.
Researchers are beginning to unravel the functional significance of key gene variants in psoriasis.
DNA changes on the IFNL3 gene have been associated with better treatment responses and natural ability to clear infection among patients with hepatitis C infection.