Hematology

For Postpartum Hemorrhage, Carbetocin Similar to Oxytocin

For Postpartum Hemorrhage, Carbetocin Similar to Oxytocin

Heat-stable carbetocin non-inferior for preventing blood loss of 500 ml, use of other uterotonic agents

FDA Permits Marketing of Devices to Create Arteriovenous Fistula

FDA Permits Marketing of Devices to Create Arteriovenous Fistula

Two devices designed to create arteriovenous fistula in patients with CKD in need of hemodialysis

Clotting Time in Transfemoral PCI Linked to Bleeding Risk

Clotting Time in Transfemoral PCI Linked to Bleeding Risk

More major bleeding seen at maximal activated clotting time greater than 290 seconds.

FDA: Updated Safety Alert Regarding Benzocaine-Associated Methemoglobinemia

FDA: Updated Safety Alert Regarding Benzocaine-Associated Methemoglobinemia

The Agency is urging manufacturers to stop marketing OTC oral drug products containing benzocaine for teething to this patient population.

Oral Anticoagulation: Reversing the Current View in Bleeding Events

Oral Anticoagulation: Reversing the Current View in Bleeding Events

Advances in new reversal agents will be key for managing patients treated with DOACs to prevent major bleeding events.

CDC: Recommendations on the Use of Heplisav-B Published

CDC: Recommendations on the Use of Heplisav-B Published

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Benefits of protection with 2 doses administered over 1 month make the vaccine an important option for prevention of HBV.

Gene Therapy May Eliminate Blood Transfusion Needs in Severe β-Thalassemia

Gene Therapy May Eliminate Blood Transfusion Needs in Severe β-Thalassemia

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With use of CD34+ cells via BB305 vector transduction, patients with severe β-thalassemia may no longer require long-term RBC transfusions as frequently or at all.

Hypertension Increase in Children Based on 2017 AAP Guidelines

Hypertension Increase in Children Based on 2017 AAP Guidelines

Increase in estimated population prevalence of elevated blood pressure from 11.8 to 14.2%.

Sickle cell trait not linked to increased risk of ischemic stroke

In this meta-analysis of prospective population-based studies, sickle cell trait was not associated with any difference in risk of first ischemic stroke.

Complex government-mandated sepsis performance measures not shown to improve survival

No moderate- or high-level evidence was found that SEP-1 or its hemodynamic interventions increase survival in septic adults.

Predicting mortality and outcomes after a subarachnoid hemorrhage

Predicting mortality and outcomes after a subarachnoid hemorrhage

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A clinical prediction tool successfully forecasts subarachnoid hemorrhage management from ruptured intracranial aneurysms.

VTE risk linked to increased television watching

VTE risk linked to increased television watching

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Increased frequency of television viewing may be linked to an increased risk for venous thromboembolism.

Pharmacomechanical thrombolysis does not reduce post-thrombotic syndrome in DVT

Pharmacomechanical thrombolysis does not reduce post-thrombotic syndrome in DVT

The addition of pharmacomechanical thrombolysis does not reduce the risk of post-thrombotic syndrome among patients with acute proximal deep vein thrombosis.

Case Study: Diarrhea and rash

Case Study: Diarrhea and rash

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A 60-year-old man with a history of gastroesophageal reflux disease presents to the emergency department with 2 to 3 days of fever, non-bloody diarrhea, and a worsening non-pruritic rash.

FDA approves new hemophilia A drug with factor VIII inhibitors

FDA approves new hemophilia A drug with factor VIII inhibitors

New FDA-approved prophylactic treatment decreases bleeding episodes hemophilia A patients with factor VIII inhibitors.

Assessing and treating disorders of primary hemostasis

Assessing and treating disorders of primary hemostasis

An evaluation begins with a focused history and physical examination, CBC count with platelet trend, and examination of the peripheral smear.

Warfarin associated with lower cancer risk in older adults

Warfarin associated with lower cancer risk in older adults

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Warfarin use may provide cancer protection across a broad range of malignant neoplasms.

No evidence that the influenza vaccine causes VTE

No evidence that the influenza vaccine causes VTE

In the 1 to 10 days after flu vaccine administration, there was no increased risk for VTE.

Non-vitamin K oral anticoagulants with other medications increase bleeding risk in A-Fib

Non-vitamin K oral anticoagulants with other medications increase bleeding risk in A-Fib

The researchers found that concurrent use of amiodarone, fluconazole, rifampin, and phenytoin was associated with increased risk of major bleeding compared with the use of NOACs alone.

Increased cancer risk found in rheumatoid arthritis patients with VTE

Increased cancer risk found in rheumatoid arthritis patients with VTE

VTE and cancer are the result of inflammation and immunological dysfunctions associated with RA.

Diagnosing a pulmonary embolism and saving a life

Diagnosing a pulmonary embolism and saving a life

A Divine guidance helps a nurse practitioner make a diagnosis that saved a patient's life.

Birth control leads to a blood clot

Birth control leads to a blood clot

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A patient presents with chest pain 6 weeks after beginning use of a contraceptive device.

Antiemetics: a clinical practice guideline update from ASCO

Antiemetics: a clinical practice guideline update from ASCO

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The updated guidelines will help clinicians prevent and manage nausea and vomiting caused by antineoplastic agents or radiation therapy in cancer patients.

Effects of the obesity paradox: VTE risk in atrial fibrillation

Effects of the obesity paradox: VTE risk in atrial fibrillation

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Researchers found a paradoxical increase in thromboembolism risk in low-weight patients with atrial fibrillation and VTE who were treated with direct oral anticoagulants.

Hepatitis B vaccine reduces risk of non-Hodgkin lymphoma in adolescents

Hepatitis B vaccine reduces risk of non-Hodgkin lymphoma in adolescents

The universal vaccination against hepatitis B virus infection prevented non-Hodgkin lymphoma in adolescents.

Restarting anticoagulation may be cost-effective in some VTE cases

Restarting anticoagulation may be cost-effective in some VTE cases

The therapy may be cost-effective for patients with a predicted 1-year VTE risk of 17.5% or more.

Most coagulation tests can be evaluated up to 8 hours after blood collection

Most coagulation tests can be evaluated up to 8 hours after blood collection

Most routine coagulation tests can be reliably assessed in tubes stored for up to 8 hours.

Warfarin dosing in HIV patients with deep venous thrombosis

Warfarin dosing in HIV patients with deep venous thrombosis

Results showed that mean induction times, analyzed in 170 patients, were 12.87 days in the HIV-infected patients and 11.19 days in the HIV-uninfected patients.

Case study: Recurrent deep vein thrombosis in thoracic outlet syndrome

Case study: Recurrent deep vein thrombosis in thoracic outlet syndrome

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A 53-year-old woman presents to the emergency room for right upper extremity deep vein thrombosis after rib resection and subclavian vein stent placement.

Thoracic outlet syndrome: A review

Thoracic outlet syndrome: A review

The condition has one fundamental pathophysiology but multiple distinct clinical presentations, including venous and neurogenic.

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