Uric acid concentration and fructose intake linked to NASH in children
Serum uric acid concentrations and fructose consumption are associated with NASH in children with non-alcoholic fatty liver disease.
(HealthDay News) — Among children with non-alcoholic fatty liver disease (NAFLD), serum uric acid concentrations and fructose consumption are associated with non-alcoholic steatohepatitis (NASH), according to a study published in the Journal of Hepatology.
Antonella Mosca, MD, from the Bambino Gesù Children's Hospital in Rome, and colleagues studied 271 obese children with NAFLD to examine factors associated with NASH. They assessed fructose consumption using a food frequency questionnaire and measured serum UA.
The researchers found that 37.6% of patients had NASH. Hyperuricemia (UA ≥ 5.9 mg/dL) was seen in 47% and 29.7% of patients with and without NASH, respectively (P =.003). After adjustment for multiple (and all) measured confounders, UA concentration and fructose consumption were independently associated with NASH (odds ratio, 2.488 [95% confidence interval, 1.87 to 2.83; P=.004] and 1.612 [95% confidence interval, 1.25 to 1.86; P =.001], respectively). There was an independent correlation for fructose consumption with hyperuricemia (odds ratio, 2.021 [95% confidence interval, 1.66 to 2.78; P =.01]).
"In conclusion, in a cohort of children and adolescents with a histological diagnosis of NAFLD and histological confirmation of NASH, we show for the first time that UA concentrations and dietary fructose consumption are independently and positively associated with NASH," the authors write.
- Mosca A, Nobili V, De Vito R, et al. Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents. J Hepatol. 2017. doi:10.1016/j.jhep.2016.12.025