Hepatology

Modest Alcohol Consumption May Reduce Mortality in NAFLD

Modest Alcohol Consumption May Reduce Mortality in NAFLD

But drinking 1.5 drinks/day linked to increased mortality after adjustment for multiple confounders.

Rituximab Linked to HBV Reactivation in Patients With Prior Functional Cure

Rituximab Linked to HBV Reactivation in Patients With Prior Functional Cure

The study authors searched MEDLINE from inception through July 2018 to obtain relevant cohort studies and randomized trials assessing HBVr incidence secondary to pharmaceutical agents.

Need for Adequate Screening for Infants With HCV Infected Mothers During Pregnancy

Need for Adequate Screening for Infants With HCV Infected Mothers During Pregnancy

One of the goals of the US Department of Health and Human Services National Viral Hepatitis Action Plan is to eliminate mother-to-infant transmission of HCV infection.

Sofosbuvir-Based Regimens Safe, Effective for Chronic Hepatitis C in the Community

Sofosbuvir-Based Regimens Safe, Effective for Chronic Hepatitis C in the Community

Investigators examined treatment response of sofosbuvir-based DAA in patients with chronic hepatitis C with compensated liver cirrhosis in a community care setting.

First Human Case of Rat Strain of Hepatitis E Found

First Human Case of Rat Strain of Hepatitis E Found

The first human case of a strain of hepatitis E previously found only in rats was diagnosed in a Hong Kong man who received a liver transplant in May 2017.

Barriers Found in PCP Knowledge of Surveillance of Hepatocellular Carcinoma

Barriers Found in PCP Knowledge of Surveillance of Hepatocellular Carcinoma

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Barriers found among PCPs in surveillance of HCC indicate the need for clinical interventions, including provider education.

Pediatric End-Stage Liver Disease Score Underestimates Mortality

Pediatric End-Stage Liver Disease Score Underestimates Mortality

The PELD score underestimates the actual probability of 90-day pretransplant mortality for children undergoing a primary liver transplant.

HCV DAA Curative Therapy Associated With Liver Fibrosis Regression

HCV DAA Curative Therapy Associated With Liver Fibrosis Regression

Curing HCV infection with direct-acting antiretrovirals is associated with regression of liver fibrosis for most patients.

Factors Associated With Faster Time to Hepatitis C Treatment

Factors Associated With Faster Time to Hepatitis C Treatment

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The researchers found a significant difference in mean time to direct-acting antiviral agent treatment among participants with public insurance payers compared with private insurance payers.

HCV Neuropsychiatric Symptoms Likely Linked to Virus' Effects on Brain Function

HCV Neuropsychiatric Symptoms Likely Linked to Virus' Effects on Brain Function

The neuropsychiatric symptoms associated with HCV infection are likely caused by the body's response to the virus' effects on brain function.

HBV Antibody Persistence in Adolescents Vaccinated With DTPa-HBV-IPV/Hib as Infants

HBV Antibody Persistence in Adolescents Vaccinated With DTPa-HBV-IPV/Hib as Infants

A robust anamnestic response was mounted in most adolescents when challenged with a dose of monovalent HBV vaccine.

Real-World Efficacy of DAAs in African Americans With Chronic HCV GT-1 Infection

Real-World Efficacy of DAAs in African Americans With Chronic HCV GT-1 Infection

Direct-acting antivirals are safe and effective in African-American patients with chronic HCV.

Toward Integrated Care for Hepatitis C Infection and Addiction

Toward Integrated Care for Hepatitis C Infection and Addiction

There is an opportunity to improve HCV treatment rates for people who inject drugs by integrating DAA therapy into current models of community-based addiction.

Majority of Patients With Liver Metastases From Colorectal Cancer Eligible for Laparoscopy

Majority of Patients With Liver Metastases From Colorectal Cancer Eligible for Laparoscopy

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In high-volume centers, patients with liver metastases from colorectal cancer may often be eligible for minimally invasive liver surgery via laparoscopy, thereby reducing potential morbidity risks associated with open surgery.

Good Outcomes for HCV-Negative Recipients of HCV Kidneys

Good Outcomes for HCV-Negative Recipients of HCV Kidneys

All 20 recipients experienced HCV cure, good quality of life, excellent renal function.

Hepatic Markers Linked to Early Predictors of Type 2 Diabetes Risk in Women

Hepatic Markers Linked to Early Predictors of Type 2 Diabetes Risk in Women

Circulating hepatic markers may predict the risk for diabetes in women.

Availability of Generic Antivirals for Hepatitis B Increasing

Availability of Generic Antivirals for Hepatitis B Increasing

Drop in median price of WHO-prequalified generic tenofovir from 208 to 32 from 2004 to 2016

Successful Screening and Referral for HIV, Hepatitis C in a Trauma Population

Successful Screening and Referral for HIV, Hepatitis C in a Trauma Population

Investigators added hepatitis C virus and HIV screening tests to standard trauma activation laboratory orders.

Coordinated Care Enhances Access to Hepatitis C Antiviral Treatment

Coordinated Care Enhances Access to Hepatitis C Antiviral Treatment

Coordinated treatment programs may improve treatment outcomes in patients with hepatitis C infection.

Liver Disease-Related Deaths Up Sharply From 1999 to 2016

Liver Disease-Related Deaths Up Sharply From 1999 to 2016

Adults aged 25 to 34 show greatest relative increase in mortality, driven by alcoholic cirrhosis.

Poor Adherence Contributes to Inadequate Uptake of Multidose Hepatitis Vaccine Schedules

Poor Adherence Contributes to Inadequate Uptake of Multidose Hepatitis Vaccine Schedules

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Adherence and completion to multidose vaccine schedules for hepatitis A, B, and A-B are low, thereby rendering vaccination ineffective.

Project ECHO: Educational Support to Improve Hepatitis Care

Project ECHO: Educational Support to Improve Hepatitis Care

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Project ECHO at Los Angeles Christian Health Center contributes to improved care of HCV in underserved populations.

Normal on-Treatment ALT Linked to Reduced Hepatic Events in Hepatitis B

Normal on-Treatment ALT Linked to Reduced Hepatic Events in Hepatitis B

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Patients with chronic hepatitis B have a lower risk of hepatic events if they achieve normal on-treatment ALT in the first 12 months of NA treatment.

CDC Issues Updated Advisory Regarding Outbreaks of Hepatitis A

CDC Issues Updated Advisory Regarding Outbreaks of Hepatitis A

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Of the 2500 cases of hepatitis A infection reported between January 2017 and April 2018, 68% were among persons who reported drug use (injection and non-injection), homelessness, or both.

DAA Therapy May Improve Select Cognitive Domains in HCV-Infected Patients

DAA Therapy May Improve Select Cognitive Domains in HCV-Infected Patients

Successful DAA therapy may lead to cognitive improvement in several domains in HCV-infected patients.

High Costs for Diagnosis, Care of Nonalcoholic Fatty Liver Disease

High Costs for Diagnosis, Care of Nonalcoholic Fatty Liver Disease

Costs were significantly higher than total annual costs per matched control with similar comorbidities.

Hepatitis C-Exposed Infants Not Adequately Screened

Hepatitis C-Exposed Infants Not Adequately Screened

Low screening rate seen at same time as increase in hepatitis C virus prevalence among pregnant women

Healthcare Program Obtains 93% of Prior Authorization Approvals for HCV Medications

Healthcare Program Obtains 93% of Prior Authorization Approvals for HCV Medications

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The Respectful & Equitable Access to Comprehensive Healthcare program obtained 93% of prior authorization approvals for hepatitis C medications.

Sofosbuvir Improves Renal Safety in Patients With Chronic Hepatitis C

Sofosbuvir Improves Renal Safety in Patients With Chronic Hepatitis C

Patients with mild, moderate renal impairment showed improvement in renal biomarkers over one year

Novel Medicaid Strategy Proposed to Increase Access to HCV Treatment

Novel Medicaid Strategy Proposed to Increase Access to HCV Treatment

A proposed novel Medicaid purchasing strategy is anticipated to increase access to medications that can eradicate hepatitis C virus infection without increasing costs at the state and federal levels.

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