Early vaccination of autologous hemopoietic stem-cell transplant (auto-HSCT) recipients during the peri-transplant period can be effective for the prevention of infections such as herpes zoster.
In a phase 3 clinical trial, early vaccination effectively prevented herpes zoster in auto-HSCT recipients.
Humoral response seen for 97.8% of HZ/su vaccine recipients vs 2% of placebo
Herpes zoster subunit vaccine more effective, less expensive than live attenuated herpes zoster vaccineJanuary 24, 2018
The adjuvanted herpes zoster subunit vaccine is more effective and less expensive than the live attenuated herpes zoster vaccine at all ages.
CDC voted for Shingrix over Zostavax as herpes zoster vaccine of choice
The risks of both stroke and myocardial infarction were highest the first year after the onset of herpes zoster and decreased with time.
The number of emergency department visits for herpes zoster have increased from 2006 to 2013.
For every 1,000 people aged 50 years that get the vaccine, only 25 cases of herpes zoster are prevented.
Herpes zoster represents the emergence of latent virus, specifically the varicella virus.
Risk for stroke, transient ischemic attack and myocardial infarction up in patients whose herpes zoster occurred before age 40 years.
Elderly patients with depression have diminished response to the shingles vaccine, but antidepressants may help.
Immunocompetent older people who have had shingles recently have a relatively low short-term risk for developing the skin condition again, regardless of vaccination status, study data show.
The shingles vaccine is safe and well tolerated in older adults, despite a small increased risk for allergic reaction in the week following vaccination.
Gralise significantly improved patient's mean pain scores compared with placebo in an 11-week clinical trial.
An elderly patient presented with an acute reaction of shingles. How soon after treatment is it advisable to administer the zoster vaccine (Zostavax)?
A 55-year-old woman who had herpes zoster and takes morphine for post-herpetic neuralgia pain, no longer wants to be on heavy-duty pain medication. What are her alternatives?
Administering the herpes zoster and pneumococcal vaccines to patients during the same visit does not appear to compromise the effectiveness of the zoster vaccine.