More research needed on managing dyslipidemia in patients with HIV

Epidemiologic studies and clinical trials are needed before specific guidelines can be developed for the management of dyslipidemia in patients with HIV.

More research needed on managing dyslipidemia in patients with HIV
More research needed on managing dyslipidemia in patients with HIV

HealthDay News -- A detailed guide has been presented for clinicians who manage dyslipidemia in patients with HIV. This guide was based on and extrapolated from guidelines for the general population, according to research published in the Journal of Clinical Pharmacology.

“Since the discovery and development of antiretroviral therapy (ART), HIV has become a chronic disease with patients living longer lives and to ages where co-morbidities such as cardiovascular disease (CVD) are prevalent,” noted Merle Myerson, MD, of Mount Sinai Roosevelt and St. Luke's Hospital in New York City, and colleagues.

“Diagnosis and management of risk factors for CVD, in particular dyslipidemia, have become an important part of the overall care for patients living with HIV infection.”

To determine which dyslipidemia guidelines for the general population work for HIV-positive patients, the investigators conducted a systematic review, noting that epidemiologic studies and clinical trials are needed before specific guidelines can be developed for the management of dyslipidemia in patients with HIV.

Clinicians should complete an assessment of cardiovascular risk, establish targets of therapy, submit a laboratory evaluation, and if appropriate, use clinical intervention techniques to address lifestyle changes. Before prescribing lipid-lowering medications, the provider should consider potential drug interactions with ART.

"The recommendations presented here are based on existing guidelines for the general population, evidence from research in patients infected with HIV, and the clinical experience of the authors," wrote the scientists.

"Management issues for which little or no information is available specific to this patient population are noted and serve to highlight the many gaps in our knowledge that will need to be addressed."

References

  1. Myerson M et al. Journal of Clinical Pharmacology. 2015; doi: 10.1002/jcph.473
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