AIDS ups age-related macular degeneration risk

the Clinical Advisor take:

Patients diagnosed with AIDS have a four-fold increase risk for developing intermediate-stage age-related macular degeneration (AMD), according to study findings published in the American Journal of Ophthalmology.

“With HIV and AIDS patients living longer than ever before, they are at an increased risk of developing several age-related diseases at an earlier age than HIV-uninfected people including cardiovascular disease and diabetes,” said Douglas A. Jabs, MD, MBA, Professor of Ophthalmology and Medicine at the Icahn School of Medicine at Mount Sinai in New York in a press release.

“Their increased risk for age-related diseases in general led us to analyze how these patients are impacted by one of the most common age-related eye diseases, macular degeneration (AMD).”

To evaluate the prevalence of intermediate-stage AMD in patients with AIDS, the investigators conducted a cross-sectional study of patients diagnosed with AIDS, aged 13 to 73 years, who were enrolled in the Longitudinal Study of the Ocular Complications of AIDS.

Of the 1,825 patients with AIDS and no ocular opportunistic infections, 9.9% had intermediate-stage AMD. Risk factors included age (odds ratio[OR] =1.9; 95% CI: 1.6-2.3; P<0.001) for every decade of age. The prevalence of AMD ranged from 4.0% for participants aged 30 to 39 years to 24.3% for participants aged 60 years or older.

Other risk factors included the HIV risk groups of injection drug use (OR=2.4, 95% CI: 1.5-3.9, P<0.001) or heterosexual contact (OR=1.9, 95% CI: 1.3-2.8, P=0.001). Compared with the HIV-uninfected population in the Beaver Dam Offspring Study, there was an approximate 4-fold increased age-adjusted prevalence of intermediate-stage AMD.

“Although the underlying mechanism leading to this increase in AMD in persons with AIDS is not yet known, it may relate to the state of chronic immune activation and systemic inflammation seen in these patients,” said Jabs.

AIDS infection ups age-related macular degeneration risk
AIDS infection ups age-related macular degeneration risk

Patients with acquired immunodeficiency syndrome (AIDS) have a four-fold increase in their risk of developing intermediate-stage age-related macular degeneration (AMD) compared to people of the same age who are not infected with HIV, according to results from the Longitudinal Study of the Ocular Complications of AIDS (LSOCA) presented today at the 2015 ARVO Annual Meeting in Denver, CO.

The results of the study, led by the National Eye Institute-funded Studies of the Ocular Complications of AIDS Research Group, were also published online in the American Journal of Ophthalmology.

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