Hospital Medicine

Joint pain

Problem/Condition

Arthralgia is pain within the joint. Arthritis is pain and inflammation of the joint. These terms are often used interchangeably for "joint pains". These should be differentiated from other pains involving the join such as tenosynovitis or bursitis.

A. What is the differential diagnosis for this problem?

The two clinical cues most helpful for diagnosis of joint pain are the joint pattern and the presence or absence of extra-articular manifestations.

Joint pattern is defined by three questions:

  • Start with the number of joints affected (some disease states are in multiple categories).

    • Monoarticular: gout, calcium pyrophosphate dihydrate deposition disease (CPPD), trauma, septic arthritis, Lyme disease, osteoarthritis (OA), tumor, and intra-articular derangement.

    • Oligoarticular (2-4 joints): psoriatic arthritis, inflammatory bowel disease, and reactive arthritis.

    • Polyarticular (5 or more joints): rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), infectious (viral, bacterial endocarditis, Lyme disease) vasculitis, Still's disease, and polymyositis.

  • Is there inflammation/synovitis?

    • Yes: RA, SLE, gout, infectious arthritis, and inflammatory bowel disease.

    • No: OA.

  • Is a "classic" joint affected?

    • Distal interphalangeal (DIP) joints: OA and psoriatic arthritis.

    • Metacarpophalangeal (MCP), wrist: RA and SLE.

    • First metatarsophalangeal (MTP): gout and OA.

    • Sacroiliac joints: ankylosing spondylitis and psoriatic arthritis.

    • Knee: gonococcus, gout and Lyme disease.

B. Describe a diagnostic approach/method to the patient with this problem

A careful approach starts with a careful history and physical examination. Inadequate history and physical commonly lead to inappropriate diagnostic testing and treatment.

Determining whether one joint or many joints are affected helps narrow the diagnosis and focuses the history and physical exam.

1. Historical information important in the diagnosis of this problem.

  • How many joints are affected?

    • If more than one did one joint start before another?

  • Are there other associated symptoms? If not then this is most likely degenerative joint disease, OA or tenosynovitis/bursitis.

    • Fevers: septic arthritis (both gonococcal and non-gonococcal), gout, RA, Still's, cancer, sarcoid, and mucocutaneous disorders.

    • Rash: psoriatic arthritis, septic arthritis, adult still's disease, parvovirus B19, and hepatitis B.

    • Nodules: gout and RA.

    • Eye involvement: reactive arthritis, ankylosing spondylitis and inflammatory bowel disease.

    • Diarrhea: inflammatory bowel disease and Whipple's disease.

  • Is there a family history of joint pains/problems?

    • Gout, CPPD and RA.

  • Previous surgery/hardware in the joint?

    • Septic arthritis until proven otherwise.

2. Physical Examination maneuvers that are likely to be useful in diagnosing the cause of this problem.

A major goal of the exam is to detect warmth over a joint, joint effusion and pain on joint motion, which are the hallmarks of synovitis.

  • Careful examination of the hands: looking for ulnar deviation, boutonniere deformity and swan neck deformity (RA).

  • Careful examination of the skin: looking for gouty tophi, extensor nodules (RA), butterfly facial rash (SLE), and jaundice (acute hepatitis B, hepatitis C).

  • Careful examination of the knee for either a bulge sign or patellar ballottement, which are useful signs for effusion.

3. Laboratory, radiographic and other tests that are likely to be useful in diagnosing the cause of this problem

Initiation evaluation of acute joint symptoms should be done after a careful history and physical exam. Panels are not recommended as this increases the frequency of finding positive results unrelated to the disease.

Complete blood count (CBC), renal function, liver function, and urine tests should be ordered if a multisystem disease is suspected. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are markers of inflammation; CRP can be used to monitor response to treatment. If there is associated weakness and muscle pain then creatinine phosphokinase (CPK) should be ordered to evaluate for myositis.

Whenever possible a joint aspiration and examination of the joint fluid is essential to the diagnosis. Four elements help with this.

  • Clarity

    • Transparent fluid is typically non-inflammatory.

    • Translucent fluid is typically present with mild inflammation.

    • Opaque fluids are typically purulent.

    • Blood effusions are seen with trauma, bleeding disorders or traumatic taps.

  • Cell count

    • Less than 2,000 white blood cell (WBC) count with a PMN count of < 25 % = non-inflammatory: degenerative joint disease (DJD), trauma and osteochondritis.

    • 2,000 - 100,000 WBC count with a PMN count of > 50% = inflammatory: RA, crystal-induced synovitis, reactive arthritis, rheumatic fever and tuberculosis.

    • Greater than 100,000 WBC count = 1) purulent: pyogenic bacterial infections - with a PMN count of >75%, isolation of pathogenic organism in synovial fluid culture, blood, or infectious site with concomitant signs of an infected joint 2) hemorrhagic: bleeding disorders or trauma.

    • WBC count of > 50,000 is specific for both infectious and inflammatory joint diseases.

  • Microscopic examination

    • Negatively birefringent: gout.

    • Positive birefringent: CPPD.

    • Gram stain can be highly specific for septic arthritis (100%) but its sensitivity is much less (45%).

  • Culture: aerobic and anaerobic cultures as well as special studies for gonococci, tuberculous or fungi as indicated. Consider sites to culture based on patient history.

Ordering chemistry studies of synovial fluid should be discouraged because they are likely to provide misleading or redundant information.

Other labs are indicated only if there is moderate suspicion for the following disease states as false positives are common:

  • RA - serum rheumatoid factor (RF)

  • SLE - antinuclear antibody (ANA) testing

Other testing such as human leukocyte antigen-B27 (HLA-B27) (ankylosing spondylitis), antineutrophil cytoplasmic antibodies (ANCA) (Wegner's), Lyme serologies, parvovirus serologies, anti-Jo-1 antibody (inflammatory myositis), and antiphospholipid antibodies are only useful when there is high clinical suspicion for these disease processes.

C. Criteria for Diagnosing Each Diagnosis in the Method Above.

See above.

D. Over-utilized or “wasted” diagnostic tests associated with the evaluation of this problem.

Imaging studies are indicated when the exam cannot localize the structure causing the symptoms. This would be mostly after significant trauma, loss of joint function, fracture, bone infection, or when malignancy is expected. Plain radiographs are often unrevealing or unhelpful for most patients with acute and new symptoms.

A. Management of joint pain.

With regards to the management of joint pain the first question you often ask is if this is a septic joint or not?

Septic joints are a medical emergency with high risk of morbidity and mortality, and require appropriate antibiotic therapy and early orthopedic consultation for drainage, lavage, and debridement.

If the causative organism cannot be determined clinically or from gram stain, treatment should be initiated with broad-spectrum antibiotics that cover Staphylococci MRSA, Streptococci, and gram-negative organisms.

The typical starting regimen for non-gonococcal septic arthritis is Vancomycin and a third-generation cephalopsorin.

Vancomycin 15 mg/kg IV every 12 hours (adjusted for weight, age and renal function).

Ceftriaxone 1g intravenous (IV) daily or cefotaxime 1g IV every 8 hours.

For gonnococcal arthiritis the treatment regiment is Azithromycin (1 g orally as a single dose) and a third-generation cephalosporin: ceftriaxone, 1 g intravenously daily (or every 12 hours if concomitant meningitis or endocarditis is suspected); or cefotaxime, 1 g intravenously every 8 hours; or ceftizoxime, 1 g intravenously every 8 hours.

Antibiotic coverage should then be adjusted once culture results become available, and continued for 6 weeks.

Remember, WBC count of > 50,000 is specific for both infectious and inflammatory joint diseases.

If the joint is not septic then management typically involves determining the diagnosis and proceeding with treatment, which often occurs in the outpatient setting and with the help of a specialist, often a rheumatologist.

B. Common Pitfalls and Side-Effects of Management of this Clinical Problem

The most useful information in evaluating musculoskeletal pain comes from the history and physical examination, with reassessment as necessary. When the diagnosis and proper management are obscure, selective ordering of tests may be the most cost-effective approach.

Joint pains are commonly managed initially with high-dose non-steroidal anti-inflammatory drugs (NSAIDS). Common contraindications to NSAIDS that may be overlooked are chronic kidney disease, congestive heart failure and history of a bleeding ulcer.

IV. What's the evidence?

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