Neutrophil-to-lymphocyte ratio may predict mortality in community-acquired pneumonia

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All participants with a neutrophil-to-lymphocyte ratio greater than 28.3 died within 30 days.
All participants with a neutrophil-to-lymphocyte ratio greater than 28.3 died within 30 days.

(HealthDay News) — Neutrophil-to-lymphocyte ratio (NLR) can predict 30-day mortality for elderly adults with community-acquired pneumonia (CAP), according to a study published online April 13 in the Journal of the American Geriatrics Society.

Emanuela Cataudella, MD, from the University of Catania in Italy, and colleagues conducted a prospective study involving 195 elderly adults admitted for CAP. The authors compared the accuracy and predictive value for 30-day mortality of traditional scores and NLR.

The researchers found that NLR predicted 30-day mortality (P <.001), with better performance for predicting prognosis than the Pneumonia Severity Index (P <.05); Confusion, Urea, Respiratory rate, Blood pressure, aged 65 and older (CURB-65); C-reactive protein; and white blood cell count (P <.001). There were no deaths in participants with a NLR below 11.12. Thirty-day mortality was 30% and 50%, respectively, for those with a NLR between 11.12 and 13.4, and for those with a NLR between 13.4 and 28.3. Within 30 days, all participants with a NLR above 28.3 died.

"In conclusion, NLR showed emerging prognostic value in predicting 30-day mortality," the authors write. "The NLR may provide clinicians with quick stratification of patients into different prognostic categories."

Reference

  1. Cataudella E, Giraffa CM, Di Marca S, et al. Neutrophil-to-lymphocyte ratio: An emerging marker predicting prognosis in elderly adults with community-acquired pneumonia. J Am Geriatr Soc. 13 April 2017. doi: 10.1111/jgs.14894
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