Infectious Diseases

New Antibiotic Shows Promise as Potential Treatment for Uncomplicated Gonorrhea

New Antibiotic Shows Promise as Potential Treatment for Uncomplicated Gonorrhea

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Unlike other antibiotics used to treat gonorrhea, zoliflodacin, a spiropyrimidinetrione antimicrobial agent, works by inhibiting DNA biosynthesis by arresting the cleaved covalent gyrase complex, thereby impeding bacterial growth.

AFM: Outbreak of Polio-Like Disease Causing Paralysis in Children

AFM: Outbreak of Polio-Like Disease Causing Paralysis in Children

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Health officials aren't sure what causes acute flaccid myelitis (AFM), a rare but serious polio-like disease that has emerged in the United States.

Infant HIV Infection Increases the Risk for Congenital CMV Infection

Infant HIV Infection Increases the Risk for Congenital CMV Infection

HIV-exposed infants have high rates of congenital cCMV infection, and in utero HIV infection seems to be a major risk factor for cCMV.

Hispanics With HIV Face Higher Risk for HPV-Related Cancer

Hispanics With HIV Face Higher Risk for HPV-Related Cancer

HIV-infected Hispanics have an increased risk for human papillomavirus-related cancers than Hispanics in the general population.

Updated HCV Treatment Guidelines for 2018 Published by AASLD-IDSA

Updated HCV Treatment Guidelines for 2018 Published by AASLD-IDSA

The American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) released updates guidelines for treating hepatitis C infection.

The Misuse of Antibiotics in Acute Pancreatitis Appears Widespread

The Misuse of Antibiotics in Acute Pancreatitis Appears Widespread

The inappropriate use of antibiotics as prophylaxis and treatment in acute pancreatitis is common, highlighting the efforts required for antibiotic stewardship.

Pneumococcal <i>H Influenzae</i> Protein D Conjugate Vaccine Effective in Children

Pneumococcal H Influenzae Protein D Conjugate Vaccine Effective in Children

The burden of childhood and infant pneumonia can be effectively reduced through the use of the pneumococcal Haemophilus influenzae protein D conjugate vaccine.

Flea-Borne Typhus Outbreak in Los Angeles County

Flea-Borne Typhus Outbreak in Los Angeles County

An outbreak of flea-borne typhus in Los Angeles County has so far resulted in 57 cases, including 20 in Pasadena and 9 in downtown Los Angeles.

Gardasil 9 Approved for Use in Women and Men 27 Through 45 Years Old

Gardasil 9 Approved for Use in Women and Men 27 Through 45 Years Old

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The approval of the expanded age range was based on data from a clinical trial which evaluated the efficacy of Gardasil (quadrivalent human papillomavirus recombinant vaccine) in 3253 women 27-45 years of age with a median duration of follow-up of 3.5 years post-dose 3.

Probiotic Use May Not Protect Against <i>Clostridium Difficile</i> Infection

Probiotic Use May Not Protect Against Clostridium Difficile Infection

In patients taking multiple antibiotics, proton pump inhibitors, or histamine receptor antagonists, the concurrent use of probiotics was associated with an increased incidence of Clostridium difficile infection

Fluoroquinolones May Aid in Reducing Mortality in Community-Acquired Pneumonia

Fluoroquinolones May Aid in Reducing Mortality in Community-Acquired Pneumonia

For patients with CAP, antibiotic regimens including a fluoroquinolone may reduce mortality risk by 1-2% compared to beta-lactams and cephalosporins alone.

A Single Combination Tablet Suppresses HIV Load Through 48 Weeks

A Single Combination Tablet Suppresses HIV Load Through 48 Weeks

A combination single tablet once-a-day regimen of doravirine/lamivudine/tenofovir disoproxil fumarate demonstrated non-inferiority and no significant adverse events when compared with continuation of established antiretroviral therapy in adults infected with HIV-1.

Improved Documentation May Help Distinguish Beta-Lactam Allergy vs Intolerance

Improved Documentation May Help Distinguish Beta-Lactam Allergy vs Intolerance

A documented β -lactam allergy was found in more than one-third of patients receiving broad-spectrum antibiotics, however, only 10% of patients were found to be truly allergic.

High Susceptibility Antibiotics Reduce Readmission Rates for Urinary Tract Infections

High Susceptibility Antibiotics Reduce Readmission Rates for Urinary Tract Infections

The use of a moderate to low susceptibility antibiotic to treat a urinary tract infection [UTI] may result in a 1.74-fold increase in the odds of an emergency department readmission within 30 days for another UTI.

Fidaxomicin Effective for Long-Term Cure of <i>Clostridium difficile</i>

Fidaxomicin Effective for Long-Term Cure of Clostridium difficile

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Fidaxomicin demonstrated the strongest evidence for being the most effective treatment in providing a long-term cure for C difficile infection.

High Rates of <i>Salmonella</i> Contamination Identified in Kratom

High Rates of Salmonella Contamination Identified in Kratom

As of end of May 2018, 199 cases of salmonellosis identified that were linked to kratom consumption.

Chagas Disease in the United States: A Growing Public Health Concern

Chagas Disease in the United States: A Growing Public Health Concern

The United States has the seventh highest prevalence of Chagas infection in the Western hemisphere, with most cases seen among immigrants from Latin America.

Public Health Vaccine Opposition Growing in the United States

Public Health Vaccine Opposition Growing in the United States

Inverse association identified between NME rate and MMR vaccine coverage of kindergarteners.

Otitis Media-Related Ambulatory Visits Declined After Pneumococcal Conjugate Vaccine

Otitis Media-Related Ambulatory Visits Declined After Pneumococcal Conjugate Vaccine

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The administration of PCV7 and PCV13 reduced the number of ambulatory visits for otitis media in pediatric patients.

Universal Purchase Programs in the United States May Not Effectively Increase Vaccination Rates

Universal Purchase Programs in the United States May Not Effectively Increase Vaccination Rates

Using state- and individual-level data from the 1995-2014 National Immunization Survey, the effect of a state's Universal Purchase adoption on vaccination rates was estimated.

Viruses Identified As Most Common Cause of Meningitis in UK Adults

Viruses Identified As Most Common Cause of Meningitis in UK Adults

Estimated annual incidence of viral meningitis is 2.73 per 100,000 UK adults.

CDC Surveillance Information for the 2017-2018 Influenza Season in the United States

CDC Surveillance Information for the 2017-2018 Influenza Season in the United States

The 2017-2018 influenza season in the United States (October 1, 2017-May 19, 2018) was a high-severity season.

National HIV Testing Day Is on June 27

National HIV Testing Day Is on June 27

Annual occasion is a good time for health care providers to encourage testing

CDC Issues Update for Resistant <i>Shigella</i> Infections

CDC Issues Update for Resistant Shigella Infections

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The CDC has identified an increasing number of Shigella isolates that test within the susceptible range for the fluoroquinolone antibiotic ciprofloxacin.

Novel Antibiotic for <i>C Difficile</i> Infection Gets FDA's QIDP Designation

Novel Antibiotic for C Difficile Infection Gets FDA's QIDP Designation

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ACX-362E is a targeted, narrow spectrum oral antibiotic that blocks the DNA replication process through inhibition of polymerase III, which has been shown to be bactericidal.

Florida Teen First Human Case of Another Mosquito-Borne Virus

Florida Teen First Human Case of Another Mosquito-Borne Virus

First documented case of Keystone infection in a human.

WHO Independent High-Level Commission on Noncommunicable Diseases Issues Recommendations

WHO Independent High-Level Commission on Noncommunicable Diseases Issues Recommendations

Although heads of state and governments have pledged to reduce premature mortality from noncommunicable diseases by one-third by 2030, many countries are not on track to achieve this goal.

Lyme Neuroborreliosis: Long-Term Survival and Health Outcomes

Lyme Neuroborreliosis: Long-Term Survival and Health Outcomes

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Lyme neuroborreliosis diagnosis had no substantial effect on long-term survival, health, or educational/social functioning yet may be associated with an increased risk of hematologic and nonmelanoma skin cancers.

CDC Says <i>E Coli</i> Outbreak Tied to Romaine Lettuce Is Over

CDC Says E Coli Outbreak Tied to Romaine Lettuce Is Over

197 cases of illness linked to the E coli outbreak, 5 of which were fatal

CDC: Get Vaccinated for Measles Before Traveling

CDC: Get Vaccinated for Measles Before Traveling

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The CDC recommends 2 doses of the MMR vaccine, which provides 97% protection against measles, prior to international travel.

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