ACIP recommends minor changes in flu vaccination practices

An ACIP panel recommended adding live-attenuated influenza vaccination as an option for individuals with egg allergy of any severity.
An ACIP panel recommended adding live-attenuated influenza vaccination as an option for individuals with egg allergy of any severity.

Members of the Advisory Committee on Immunization Practices (ACIP) recently voted to recommend some changes for  the influenza vaccine and reviewed the latest efficacy data on influenza vaccine.

In the 2015 to 2016 season, through February 12, 2016, influenza vaccine effectiveness was 59% against medically-attended influenza, and there was significant protection against circulating influenza H1N1pdm09 and influenza B viruses, according to data presented at the committee meeting.

Although data remain preliminary, the panel heard information from the U.S. Flu VE Network that suggested the vaccine was: 51% effective against the H1N1 viruses responsible for most flu illness this season; 76% effective against all influenza B viruses; and 79% against the B/Yamagata lineage of B viruses.

In a separate discussion at ACIP, John Kelso, MD, from the Scripps Clinic in San Diego, presented data from 3 studies that collectively described 1129 children with an egg allergy, including 412 with a history of anaphylaxis to egg ingestion, who did not have any immediate systemic reactions to the influenza vaccine.

After the presentations, the ACIP panel voted to recommend adding the live-attenuated influenza vaccine as an option for individuals with an egg allergy of any severity.

The panel also noted that regardless of a recipient's allergy history, all vaccines should be administered in settings in which “personnel and equipment for rapid recognition and treatment of anaphylaxis are available.”

They also voted to make a note in the recommendation that individuals with an egg allergy who experienced only hives after exposure to egg should receive influenza vaccine, and noted that any individuals who had severe reactions to egg other than hives should receive an influenza vaccination in a medical setting with a health care provider present.

The panel voted unanimously with 3 abstentions to recommend changes to the recommendation. The panel agreed that the wording of the recommendation may change before its official adoption and publication.

Reference

  1. Karron R, Brammer L, Hachey W, et al. Influenza: Proposed Recommendations for 2016-2017. Presented at the Advisory Committee on Immunization Practices; February 24, 2016, Atlanta, GA.
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