Laser therapy plus topical effective for generalized plaque psoriasis

Share this article:
Laser therapy plus topical effective for generalized plaque psoriasis
Laser therapy plus topical effective for generalized plaque psoriasis

Excimer laser therapy used in combination with topical clobetasol spray and calcitriol ointment may be effective treatment for patients with moderate to severe generalized psoriasis, according to results of a recent study published in the Journal of Dermatological Treatment.

Ethan C. Levin, MD, Psoriasis and Skin Treatment Center, University of California, San Francisco, and colleagues conducted a 12-week open-label pilot study to determine efficacy of combination therapy using 308-nm excimer laser along with clobetasol propionate spray and calcitriol ointment for the treatment of moderate to severe generalized psoriasis.

Twenty-one patients with moderate to severe psoriasis received treatments twice weekly with XTRAC® Velocity 308-nm excimer laser. Patients also were treated twice daily with both clobetasol propionate spray followed by calcitriol ointment.

By the end of the study, 76% of patients had at least a 75% reduction in Psoriasis Area and Severity Index (PASI-75) and 52% of patients had a Physicians Global Assessment of “clear” or “almost clear.”

The researchers concluded that laser therapy combined with an optimized topical regimen of clobetasol spray and calcitriol ointment appears to be effective for treatment of moderate to severe generalized psoriasis. This treatment also “avoids the risk of side effects associated with many systemic agents,” the researchers wrote.

References

  1. Levin EC. J Dermatol Treat. 2014; doi:10.3109/09546634.2013.860210.
Share this article:
You must be a registered member of Clinical Advisor to post a comment.
close

Next Article in Web Exclusives

More in Web Exclusives

Diabetes drug lowers CVD risk in type 2 diabetes

Diabetes drug lowers CVD risk in type 2 ...

Fenofibrate improved lipoprotein profile more in women; CVD event reduction similar for men, women.

HPV vaccine safe for teens, provides long-term benefits

HPV vaccine safe for teens, provides long-term benefits

Vaccination-induced anti-HPV response persists through 96 months for all HPV vaccine types.

Discussing direct benefits increases parents' intent to vaccinate

Discussing direct benefits increases parents' intent to vaccinate

Emphasizing only societal benefits of MMR vaccine does not increase intention of parents to vaccinate.