Surgery may not improve outcomes in early-stage prostate cancer
Results of the study showed that patients with early-stage prostate cancer who have surgery to remove their tumor do not live longer than those who receive no treatment.
(HealthDay News) — Men with early-stage prostate cancer who have surgery to remove their tumor do not live longer than those who receive no treatment at all, according a study published in the New England Journal of Medicine.
Timothy Wilt, MD, MPH, a clinical investigator with the Minneapolis Veterans Affairs Health Care System, and colleagues randomly assigned 731 men with low-risk prostate cancer to either undergo surgery or observation only.
Of the men who underwent prostate cancer surgery, 223 (61.3%) died during as much as 2 decades of follow-up, compared with 245 men (66.8%) placed on observation. The difference was not statistically significant, the researchers noted. In addition, 27 men (7.4%) in the surgery group died of prostate cancer, compared with 42 men (11.4%) in the observation group. That difference also was not statistically significant, according to the investigators. At the same time, nearly 1 in 3 men who had the surgery experienced long-term complications, such as urinary incontinence and erectile dysfunction, Wilt told HealthDay.
"Our results demonstrate that for the large majority of men with localized prostate cancer, selecting observation for their treatment choice can help them live a similar length of life, avoid death from prostate cancer and prevent harms from surgical treatment," Wilt said.
- Wilt TJ, Jones KM, Barry MJ, et al. Follow-up of prostatectomy versus observation for early prostate cancer. N Eng J Med. 2017;377:132-142. doi:10.1056/NEJMoa1615869