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Module 3: Initiating Biologics in Steroid-Dependent UC Patients

Module 3: Initiating Biologics in Steroid-Dependent UC Patients

Format

Clinical Review

Time to Complete

45 minutes for AMA/35 minutes for ANCC credits

Released

November 30, 2017

Expires

November 30, 2018
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Maximum Credits

0.75 / AMA PRA Category 1 Credit(s)TM
0.60 / CNE Contact Hour(s)

Accredited Provider

Jointly provided by Postgraduate Institute for Medicine and Strategic Consultants International

Commercial Supporter

Supported by an educational grant from Takeda Pharmaceuticals, U.S.A. Inc

Program Description

Minimizing use of corticosteroids is a pivotal aspect of management of patients with UC. Although repeated courses and prolonged use of corticosteroids have been associated with serious adverse events, corticosteroids are still highly used in UC patients, possibly due to their efficacy to induce remission. However, corticosteroids are ineffective for maintaining remission and can create dependency. Corticosteroid-dependent patients require consideration for effective maintenance therapies with steroid-sparing effects, such as biologic therapy (anti-TNFs or anti-integrin). This module discusses how to manage steroid-dependent UC patients, exploring evidence of clinical overuse of corticosteroids, occurrence of corticosteroid-associated adverse events, and also analyzing clinical evidence on steroid-sparing therapeutic strategies.

Intended Audience

Physicians and registered nurses

Educational Objectives

Upon completion of this activity, participants should be better able to:

  • Recognize the risks of corticosteroid overuse and short- and long-term side-effects
  • Describe strategies that can minimize steroid exposure in UC patients in the long-term
  • Evaluate decision-making regarding when and how to withdraw corticosteroids in steroid-dependent patients

Accreditor Disclosure of Conflicts of Interest Policy

Postgraduate Institute for Medicine (PIM) requires instructors, planners, managers and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest (COI) they may have related to the content of this activity. All identified COI are thoroughly vetted and resolved according to PIM policy. PIM is committed to providing its learners with high quality CME activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of a commercial interest.

The faculty reported any financial relationships or relationships to products or devices they or their spouse/life partner with commercial interests related to the content of this CME activity under the Faculty section below.

Faculty

Course Author
Bruce E. Sands, MD, MS

Chief, Henry D. Janowitz Division of Gastroenterology
Icahn School of Medicine at Mount Sinai
New York, NY

Dr. Sands discloses the following:
Consulting fees: AbbVie, Allergan Sales, Amgen, Arena Pharmaceuticals, Boehringer Ingelheim, Celgene, Cowen
Services Company, EnGene, Gilead, Janssen Biotech, Lilly, MedImmune, Oppilan Pharma, Pfizer, Rockpointe, Shire,
Takeda, Target Pharmasolutions, Therevance Biopharma R&D, TiGenix, UCB, Vivelix Pharmaceuticals
Speaker fees: American Gastroenterological Association, American College of Gastroenterology, IMEDEX, Takeda,
Vindico Medical Education
Editor fees: AGA Institute

Course Director
Miguel D. Regueiro, MD

IBD Clinical Medical Director
Division of Gastroenterology, Hepatology and Nutrition
Department of Medicine
University of Pittsburgh School of Medicine
Pittsburgh, PA

Dr. Regueiro discloses the following:
Consulting Fees: Abbvie, Takeda, Amgen, Janssen, Pfizer, UCB

Joint Provider Disclosures

The following PIM planners and managers, Trace Hutchison, PharmD, Samantha Mattiucci, PharmD, CHCP, Judi Smelker-Mitchek, RN, BSN, and Jan Schultz, RN, MSN, CHCP, have nothing to disclose. The SCI planners and managers, Ian Morgan MSc, Elena Urso BSc, and Ana Costa, PhD, have nothing to disclose.

Credit

0.75

Type

AMA PRA Category 1 Credit(s)TM

Accreditation Statement

This activity has been planned and implemented in accordance with the accreditation requirements and polices of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Postgraduate Institute for Medicine and Strategic Consultants International. The Postgraduate Institute for Medicine is accredited by the ACCME to provide continuing medical education for physicians.

Designation Statement

The Postgraduate Institute for Medicine designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Credit

0.60

Type

CNE Contact Hour(s)

Accreditation Statement

The Postgraduate Institute for Medicine is accredited with distinction as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation.

Designation Statement

This educational activity for 0.60 contact hour(s) is provided by the Postgraduate Institute for Medicine.

Disclosure of Unlabeled Use

This education activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indication, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, a review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Instructions

This activity is offered at no cost to participants. Please proceed with the activity until you have successfully completed this program and evaluation, and have received a digital copy of your credit certificate. Your online certificate will be saved on myCME within your Profile/CME History, which you can access at any time.

For information about the accreditation of this program, please contact Postgraduate Institute for Medicine AT (303) 799-1930 and via email at inquires@pimed.com.

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