In the US Burden of Disease Report, the leading causes of death were ischemic heart disease, lung cancer, chronic obstructive pulmonary disease, Alzheimer's disease, and colorectal cancer while the leading causes of disability were low back pain, major depressive disorder, and diabetes.
Investigators believe the siponimod EXPAND study is the first trial of disease-modifying therapy to show superiority over a placebo for disability progression in SPMS.
No significant difference in mortality for those undergoing whole body CT vs selective CT approach
The NIA-AA has proposed updates to the 2011 guidelines for symptomatic stages of Alzheimer's disease to include the idea that certain imaging and cerebrospinal fluid biomarkers are valid proxies for neuropathologic changes of AD.
In Utero Exposure to Multiple AEDs, Sodium Valproate Linked to Poor Educational Attainment in ChildhoodApril 09, 2018
In utero exposure to AEDs in combination, or sodium valproate alone, is associated with a significant decrease in attainment in national educational tests for 7-year-old children.
The adjusted analysis also demonstrated that the code stroke system was associated with a decreased risk for post-stroke epilepsy within 5 years of stroke.
A reasonable proportion of patients with epilepsy who have received treatment with pharmaceutical-grade cannabidiol products along with antiepileptic drugs have experienced a decrease in seizure frequency.
A meta-analysis reviewing the effect of parent-child book reading interventions revealed a positive correlation between such interventions and a broad range of beneficial psychosocial outcomes, including social-emotional competence, quality of life, and parenting competence.
Alcohol use disorders are the strongest modifiable risk factors for onset of all types of dementia, especially early-onset dementia.
Individuals with gluten neuropathy experienced less peripheral neuropathic pain when adhering to strict gluten-free diets.
Cognitive decline risk is lowered in individuals aged 85 and older with high cholesterol.
Intensive blood pressure control not linked to changes in cerebral perfusion in patients with cerebral small vessel diseaseMarch 14, 2018
In patients with severe cerebral small vessel disease, a strategy of intensive blood pressure control did not significantly alter whole brain blood flow when compared to standard blood pressure control.
HbA1C, diabetes status, and cognitive decline during a span of 10 years were compared using data from the English Longitudinal Study of Ageing.
The FDA announced that it has approved a new technology known as the RadioGenix System to produce the country's own supply of the radioisotope Technetium-99m (Tc-99m).
Modulate electrical stimulation of the amygdala may improve declarative memory without provoking any emotional reaction.
Among NFL football players who began their careers between 1982 and 1992, career participation in the NFL, compared with limited NFL exposure obtained primarily as an NFL replacement player during a league-wide strike, was not associated with a statistically significant difference in long-term all-cause mortality.
A clinical prediction tool successfully forecasts subarachnoid hemorrhage management from ruptured intracranial aneurysms.
Ill-timed administration of benzodiazepine treatment in pediatric patients with refractory convulsive status epilepticus is associated with many short-term adverse events.
At the 2018 International Stroke Conference in Los Angeles, the AHA/ASA released updated guidelines for the early management of ischemic strokes, which account for 87% of all strokes.
Caffeine and its 3 downstream metabolites may be helpful as a biomarker for Parkinson disease.
A 42-year-old man presents to the emergency department with vertigo that is worse with head motion as well as vomiting, but has no headache or abdominal pain.
In patients with mild Alzheimer's disease solanezumab, an antibody designed to facilitate clearance of amyloid-beta plaques, did not significantly reduce cognitive decline over time.
Bimodal auditory-somatosensory treatment is noninvasive and showed no side effects.
Apathy and depressive symptoms are independently associated with incident dementia in community-dwelling older people.
The American Academy of Neurology has released updated guideline recommendations for mild cognitive impairment.
Intake of primary nutrients and bioactives in green leafy vegetables is associated with slower cognitive decline.
Attaining higher education may aid in the prevention of Alzheimer's disease.
Ginkgo biloba extract, along with aspiring, may help cognition in acute ischemic stroke patients.
Non-pharmaceutical treatments improved 4 cognitive and behavioral domains in children with epilepsy.
Post-seroconversion brain morphology can occur in HIV patients, but aviremia maintenance via cART can slow of prevent brain injuries.