Neurology

Health burden varies significantly by state in the US

In the US Burden of Disease Report, the leading causes of death were ischemic heart disease, lung cancer, chronic obstructive pulmonary disease, Alzheimer's disease, and colorectal cancer while the leading causes of disability were low back pain, major depressive disorder, and diabetes.

Siponimod Reduces Risk for Disability Progression in Secondary Progressive MS

Siponimod Reduces Risk for Disability Progression in Secondary Progressive MS

Investigators believe the siponimod EXPAND study is the first trial of disease-modifying therapy to show superiority over a placebo for disability progression in SPMS.

Whole Body CT Not Linked to Reduced Mortality in Blunt Trauma

Whole Body CT Not Linked to Reduced Mortality in Blunt Trauma

No significant difference in mortality for those undergoing whole body CT vs selective CT approach

Newly Proposed Definition of Alzheimer's Disease Focuses on Biologic Criteria

Newly Proposed Definition of Alzheimer's Disease Focuses on Biologic Criteria

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The NIA-AA has proposed updates to the 2011 guidelines for symptomatic stages of Alzheimer's disease to include the idea that certain imaging and cerebrospinal fluid biomarkers are valid proxies for neuropathologic changes of AD.

In Utero Exposure to Multiple AEDs, Sodium Valproate Linked to Poor Educational Attainment in Childhood

In Utero Exposure to Multiple AEDs, Sodium Valproate Linked to Poor Educational Attainment in Childhood

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In utero exposure to AEDs in combination, or sodium valproate alone, is associated with a significant decrease in attainment in national educational tests for 7-year-old children.

Code Stroke System Reduces Post-Stroke Epilepsy Risk in Older Adults

Code Stroke System Reduces Post-Stroke Epilepsy Risk in Older Adults

The adjusted analysis also demonstrated that the code stroke system was associated with a decreased risk for post-stroke epilepsy within 5 years of stroke.

Cannabinoids May Decrease Seizure Frequency in Refractory Epilepsy

Cannabinoids May Decrease Seizure Frequency in Refractory Epilepsy

A reasonable proportion of patients with epilepsy who have received treatment with pharmaceutical-grade cannabidiol products along with antiepileptic drugs have experienced a decrease in seizure frequency.

Parent-child reading interventions have positive psychosocial effects

A meta-analysis reviewing the effect of parent-child book reading interventions revealed a positive correlation between such interventions and a broad range of beneficial psychosocial outcomes, including social-emotional competence, quality of life, and parenting competence.

Alcohol use disorders are major risk factor for dementia

Alcohol use disorders are major risk factor for dementia

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Alcohol use disorders are the strongest modifiable risk factors for onset of all types of dementia, especially early-onset dementia.

Gluten-free diet associated with reduced neuropathy pain

Gluten-free diet associated with reduced neuropathy pain

Individuals with gluten neuropathy experienced less peripheral neuropathic pain when adhering to strict gluten-free diets.

High total cholesterol linked to lower risk of cognitive decline in elderly

High total cholesterol linked to lower risk of cognitive decline in elderly

Cognitive decline risk is lowered in individuals aged 85 and older with high cholesterol.

Intensive blood pressure control not linked to changes in cerebral perfusion in patients with cerebral small vessel disease

In patients with severe cerebral small vessel disease, a strategy of intensive blood pressure control did not significantly alter whole brain blood flow when compared to standard blood pressure control.

HbA1C levels linked to cognitive decline in diabetes

HbA1C levels linked to cognitive decline in diabetes

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HbA1C, diabetes status, and cognitive decline during a span of 10 years were compared using data from the English Longitudinal Study of Ageing.

FDA approves new MRI technology to produce technetium-99m

FDA approves new MRI technology to produce technetium-99m

The FDA announced that it has approved a new technology known as the RadioGenix System to produce the country's own supply of the radioisotope Technetium-99m (Tc-99m).

Long-term memory enhanced by electrical stimulation of the amygdala

Long-term memory enhanced by electrical stimulation of the amygdala

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Modulate electrical stimulation of the amygdala may improve declarative memory without provoking any emotional reaction.

NFL players do not have significantly increased mortality risk

NFL players do not have significantly increased mortality risk

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Among NFL football players who began their careers between 1982 and 1992, career participation in the NFL, compared with limited NFL exposure obtained primarily as an NFL replacement player during a league-wide strike, was not associated with a statistically significant difference in long-term all-cause mortality.

Predicting mortality and outcomes after a subarachnoid hemorrhage

Predicting mortality and outcomes after a subarachnoid hemorrhage

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A clinical prediction tool successfully forecasts subarachnoid hemorrhage management from ruptured intracranial aneurysms.

Delayed treatment after epileptic seizure onset leads to higher mortality rate

Delayed treatment after epileptic seizure onset leads to higher mortality rate

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Ill-timed administration of benzodiazepine treatment in pediatric patients with refractory convulsive status epilepticus is associated with many short-term adverse events.

Acute ischemic stroke: new guidelines open treatment window to 24 hours

Acute ischemic stroke: new guidelines open treatment window to 24 hours

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At the 2018 International Stroke Conference in Los Angeles, the AHA/ASA released updated guidelines for the early management of ischemic strokes, which account for 87% of all strokes.

Low caffeine level may be biomarker for Parkinson disease

Low caffeine level may be biomarker for Parkinson disease

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Caffeine and its 3 downstream metabolites may be helpful as a biomarker for Parkinson disease.

Case Study: Dizziness in a 42-year-old man

Case Study: Dizziness in a 42-year-old man

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A 42-year-old man presents to the emergency department with vertigo that is worse with head motion as well as vomiting, but has no headache or abdominal pain.

Solanezumab does not change cognitive decline in mild Alzheimer’s disease

In patients with mild Alzheimer's disease solanezumab, an antibody designed to facilitate clearance of amyloid-beta plaques, did not significantly reduce cognitive decline over time.

Novel device may ease symptoms of tinnitus

Novel device may ease symptoms of tinnitus

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Bimodal auditory-somatosensory treatment is noninvasive and showed no side effects.

Dementia risk linked to apathy, depression in older adults

Dementia risk linked to apathy, depression in older adults

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Apathy and depressive symptoms are independently associated with incident dementia in community-dwelling older people.

Mild cognitive impairment: a practice guideline update

Mild cognitive impairment: a practice guideline update

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The American Academy of Neurology has released updated guideline recommendations for mild cognitive impairment.

Green leafy vegetable consumption linked to slower cognitive decline

Green leafy vegetable consumption linked to slower cognitive decline

Intake of primary nutrients and bioactives in green leafy vegetables is associated with slower cognitive decline.

Higher education may help reduce Alzheimer's disease risk

Higher education may help reduce Alzheimer's disease risk

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Attaining higher education may aid in the prevention of Alzheimer's disease.

Ginkgo biloba extract aids cognition in stroke patients

Ginkgo biloba extract aids cognition in stroke patients

Ginkgo biloba extract, along with aspiring, may help cognition in acute ischemic stroke patients.

Non-pharma therapies may offer seizure relief for children with epilepsy

Non-pharma therapies may offer seizure relief for children with epilepsy

Non-pharmaceutical treatments improved 4 cognitive and behavioral domains in children with epilepsy.

Combination ART may prevent progressive brain injury in HIV patients

Combination ART may prevent progressive brain injury in HIV patients

Post-seroconversion brain morphology can occur in HIV patients, but aviremia maintenance via cART can slow of prevent brain injuries.

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