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Talzenna Approved for Germline BRCA-Mutated, HER2-Negative Breast Cancer

Talzenna Approved for Germline BRCA-Mutated, HER2-Negative Breast Cancer

Talzenna, a poly (ADP-ribose) polymerase (PARP) inhibitor, was evaluated in EMBRACA, an open-label trial that randomized patients with gBRCAm HER2-negative locally advanced or metastatic breast cancer (N=431) to receive talazoparib 1mg or physician's choice of chemotherapy (capecitabine, eribulin, gemcitabine, or vinorelbine).

Weight Loss May Reduce Breast Cancer Risk in Postmenopausal Women

Postmenopausal women with weight loss have a reduced risk for breast cancer.

Higher Levels of Anti-CA15.3 and Anti-CA125 Linked to Increased Risk for Mucinous Epithelial Ovarian Cancer

Researchers used the EPIC Cohort to identify whether anti-CA125 and anti-CA15.3 antibodies alone or in combination with antigens may determine epithelial ovarian cancer risk.

Better Efforts Needed for Cancer Patients With Pessimistic Illness Perceptions

Among cancer survivors, illness perception may affect patient health-related quality of life and mortality.

Ovarian Cancer Risk Reduced With Regular, Low-Dose Aspirin

Although ovarian cancer risk may be reduced with regular use of low-dose aspirin, the use of nonaspirin analgesics may increase the risk of ovarian cancer among long-term, high-quantity users.

FDA Amends Food Additive Regulations to No Longer Allow Use of 7 Substances

The petition was submitted by a number of non-profit organizations including the Center for Science in the Public Interest and the Breast Cancer Fund.

Weight Loss May Predict Cancer Diagnosis in Primary Care

Weight loss may indicate a cancer diagnosis in patients presenting in primary care, specifically when weight loss correlates to another cancer-related clinical feature.

CLINICAL FEATURES

Adjuvant Chemo With Endocrine Therapy for HR+/HER2- Breast Cancer

Adjuvant Chemo With Endocrine Therapy for HR+/HER2- Breast Cancer

Although endocrine therapy following surgery is recommended for HR-positive/HER2-negative, axillary node-negative breast cancers, the value of adjuvant chemotherapy in the setting of moderate risk is unclear.

Case Study: Chest Pain and Shortness of Breath in a Patient with Colorectal Cancer

Case Study: Chest Pain and Shortness of Breath in a Patient with Colorectal Cancer

A 64-year-old woman who was recently diagnosed with colorectal cancer is brought to the emergency department with substernal chest pain and shortness of breath.

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