Nearly all of kratom's major compounds bind to opioid receptors in the human brain, and 2 of the top 5 most prevalent compounds activate those receptors, FDA Commissioner Scott Gottlieb said in a statement. In addition, there have been 44 reported deaths associated with the use of kratom, often in combination with other substances, Gottlieb said.
DisposeRx is a free method to safely and responsibly dispose of prescription opioids.
Duration, more than dosage, may increase the risk of misuse in opioid naïve patients.
A FNP reflects on his experiences working with pain management patients prescribed opioids.
Clinicians are in the unique position to educate and counsel middle-aged adults about their opioid use and influence strategies needed to provide effective pain control.
Co-prescribing naloxone and opioids in primary care is recommended for patients who have a high risk for opioid overdose.
Current surgical and prescribing practices may have a hand in exacerbating the nation's burgeoning opioid epidemic.
Gabapentinoids may be overprescribed, in part as a response to the opioid epidemic.
The number of physicians adopting buprenorphine therapy has not kept pace with the magnitude of the opioid epidemic.
The FDA commissioned the report to provide an update on current evidence on research, care, and education in the pain field, and to identify actionable measures for the FDA to more adequately address the ongoing opioid epidemic.
Users of opioid-only agents had significantly increased rates of emergency room visits and hospitalizations for ischemic heart disease and IHD-related mortality.
However, the number of opioids prescribed decreased between 2010 and 2015.
Among the nearly 40 million Americans who have a mental health condition, about 19% use prescription opioids.
Clinicians should consider limiting pre-TKA opioid prescriptions to optimize the benefits of TKA.
Most opioid-dependent pregnant patients understand that intravenous drug use is a major transmission modality of HCV.
Many PA students and practicing PAs did not feel that their PA program adequately trained them to screen for opioid abuse.
In patients receiving methadone maintenance treatment, researchers observed, on average, 25 fewer deaths/1000 person years than in patients who discontinue it.
Researchers found that some surgery patients may face a higher risk of becoming dependent on opioids.
Patients who are taking opioids can manage their tolerance by taking magnesium 500mg.
The recently released CDC guidelines on opioid prescribing remain a topic of debate.
Patients with chronic pain who are hospitalized have a higher risk of morbidity and mortality, longer lengths of stay, and more frequent readmissions than patients without chronic pain.
The drug combination significantly contributes to the overall population risk of opioid overdose.
The Veterans Administration and Department of Defense issue a clinical practice guideline regarding opioid therapy for chronic pain in veterans.
Kratom might be a safer alternative than oxycodone or other narcotics.
Patients diagnosed with a prior psychiatric condition have increased odds of long-term opioid receipt than patients without these conditions.
Research has shown that use of suboxone and methadone, in conjunction with counseling, can be effective addiction treatment.
Patients provided with at least 2 refills were 2.25 times more likely to develop an opioid dependency.
Screening for pain at every visit is recommended, and management and treatment options are specified.
The use of injectable, extended-release oxymorphone and syringe sharing was linked to an outbreak of HIV infections in Indiana.
The adoption of various state laws did not affect rates of opioid prescription or strength of dose.