Pharmacology

Prescribing generics over brand-name drugs could save billions of dollars

Prescribing generics over brand-name drugs could save billions of dollars

Over a 2-year period, the researchers estimated that the United States could have saved $73 billion by prescribing generic equivalents.

Metformin more effective than sulfonylureas for reducing cardiovascular mortality in diabetes patients

Metformin more effective than sulfonylureas for reducing cardiovascular mortality in diabetes patients

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Compared with other drugs for type 2 diabetes, metformin is superior for reducing the risk of cardiovascular mortality.

Use of potentially lethal drug combinations increases in the elderly

Use of potentially lethal drug combinations increases in the elderly

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The rates of dangerous drug combinations, supplement use, and polypharmacy are increasing among older adult patients.

Drug combos not more effective than naproxen alone for acute low back pain

Drug combos not more effective than naproxen alone for acute low back pain

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When compared to naproxen alone, the combination of either cyclobenzaprine or oxycodone/acetaminophene plus naproxen does not as effectively improve acute, nontraumatic lower back pain.

American College of Physicians recommends prescribing generic medications

American College of Physicians recommends prescribing generic medications

Clinicians should prescribe generic medications over brand-name drugs when they can because the generics are less expensive and molecularly identical.

Grapefruit-drug interactions


Grapefruit-drug interactions


Grapefruit can safely be consumed with the majority of medications, and patients with concerns should consult with their physicians.

Prescription use common in pregnant women with Medicaid

Prescription use common in pregnant women with Medicaid

Pregnant women enrolled in Medicaid are commonly prescribed a variety of prescription medications.

Integrative and OTC treatment of headache

Integrative and OTC treatment of headache

Headache is one of the most common complaints in outpatient practice. There are 10 things that clinicians need to know to help treat their patients with headache.

Heart attack, stroke warnings updated for NSAIDs

Heart attack, stroke warnings updated for NSAIDs

The FDA will require manufacturers to include updated warnings on prescription and OTC NSAIDs.

In menopausal women, SSRIs increase fracture risk

In menopausal women, SSRIs increase fracture risk

Women prescribed SSRIs for menopausal symptoms had a sustained increased risk for fracture.

Fewer adverse outcomes when pharmacists manage warfarin therapy

Fewer adverse outcomes when pharmacists manage warfarin therapy

Patients whose warfarin therapy was managed by pharmacists had reduced adverse outcomes compared with usual care.

Grapefruit contraindicated with increasing numbers of drugs

Grapefruit contraindicated with increasing numbers of drugs

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Take thorough dietary histories to be sure patients are not taking medications that adversely interact with the fruit.

Statin discontinuation may increase quality of life in patients with life-limiting illness

Statin discontinuation may increase quality of life in patients with life-limiting illness

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Patients with life-limiting illnesses often take statins, and discontinuing these can increase quality of life.

Psychotropic medication use in children

Psychotropic medication use in children

Whether to prescribe psychotropic medications in children with anxiety and sleep disorders is a common ethical dilemma faced by primary care providers.

Male with symptomatic
 benign prostatic hyperplasia


Male with symptomatic
 benign prostatic hyperplasia


Several pharmaceutical options exist for men with symptomatic benign prostatic hyperplasia who cannot tolerate alpha blockers.

Sam's Club savings program now offers low-cost Alzheimer, diabetes medications

Sam's Club savings program now offers low-cost Alzheimer, diabetes medications

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More than 200 generic medications are available for $4 and more than 400 generic prescriptions are available for $10.

Keeping an accurate 
medication list is critical 
to a patient's care


Keeping an accurate 
medication list is critical 
to a patient's care


Educating patients can help them see the importance of having an accurate medication list.

Experts question safety of acetaminophen

Experts question safety of acetaminophen

Heavy use of acetaminophen is associated with kidney disease and bleeding in the digestive tract.

Patients may be mixing medications with alcohol

Patients may be mixing medications with alcohol

Nearly 42% of patients considered current drinkers reported taking a medication that can interact with alcohol.

Results of medicine-adherence interventions inconsistent

Results of medicine-adherence interventions inconsistent

More research needs to be done in order to demonstrate the effectiveness of interventions designed to improve patient adherence to prescribed medications.

Stopping selective serotonin reuptake inhibitors does not cut miscarriage risk

Stopping selective serotonin reuptake inhibitors does not cut miscarriage risk

Increased miscarriage risk has been observed in both female patients who have been exposed to selective serotonin reuptake inhibitors (SSRIs) and patients who discontinued use.

High-dose aspirin still prescribed after myocardial infarction

High-dose aspirin still prescribed after myocardial infarction

Although data suggests low-dose aspirin offers similar results without the risk of bleeding, high-dose aspirin is still more commonly prescribed.

FDA approves extended-release painkiller

FDA approves extended-release painkiller

The medication is designed to deter abuse of the drug by snorting or injection.

Niacin, laropiprant may not decrease vascular risk

Niacin, laropiprant may not decrease vascular risk

Adverse effects have been found in 34.2% and 32.5% of patients prescribed extended-release niacin.

Pharmacology update: 2014 drug trends

Pharmacology update: 2014 drug trends

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More orphan drugs approved in recent years are filling the need for treating rare disease and medical conditions.

CDC: Nearly half of all Americans use prescription drugs

CDC: Nearly half of all Americans use prescription drugs

Overall prescription use has increased in kids, adults and the elderly, but access disparities still exist for uninsured.

Genetic variant explains altered warfarin response in blacks

Genetic variant explains altered warfarin response in blacks

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Including a novel genetic marker in warfarin dosing algorithms resulted in a 21% relative improvement dosing for African American patients.

Mixing herbal and 
prescription meds

Mixing herbal and 
prescription meds

Patients often consider supplements and herbs harmless, but combining them with other drugs can have devastating consequences.

Is medication causing your patient's insomnia?

Is medication causing your patient's insomnia?

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Many medications can cause or worsen insomnia. It is important to ask patients when their symptoms started and if they began occurring after initiating a new medication.

Sepsis drug withdrawn from market

Eli Lilly announced that it is pulling drotrecogin alfa (Xigris) from all markets after a major clinical trial failed to show a survival benefit among patients taking the drug.

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