Pharmacology

FDA: Some liquid pharmaceuticals recalled due to possible bacterial contamination

FDA: Some liquid pharmaceuticals recalled due to possible bacterial contamination

The FDA has announced a recall of liquid pharmaceutical products because of possible bacterial contamination that could cause severe infections.

Idarucizumab reverses anticoagulant effect of dabigatran in emergency situations

Idarucizumab reverses anticoagulant effect of dabigatran in emergency situations

Researchers found that idarucizumab is effective for dabigatran reversal among patients with uncontrolled bleeding and who are undergoing urgent surgery.

FDA approves first generic version of Truvada for HIV

FDA approves first generic version of Truvada for HIV

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The drug is indicated for use in combination with other antiretroviral agents for the treatment of pediatric and adult patients with HIV-1.

AMA calls for transparency in drug pricing

AMA calls for transparency in drug pricing

The American Medical Association adopted new policies on drug pricing to protect patients.

Side effects may affect medication nonadherence in patients with chronic disease

Side effects may affect medication nonadherence in patients with chronic disease

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Almost half of participants reported that they never received information regarding the side effects of their medication from their prescriber.

About 1 in 3 drugs have safety concerns after FDA approval

About 1 in 3 drugs have safety concerns after FDA approval

Almost one third of the new therapeutics approved by the FDA between 2001 and 2010 were affected by a postmarket safety event.

Pharmacists can help optimize care in patients with hepatitis C virus

Pharmacists can help optimize care in patients with hepatitis C virus

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Drug-drug interactions are common in patients taking hepatitis C virus medications, and consulting with a pharmacist can be beneficial.

Prescribing generics over brand-name drugs could save billions of dollars

Prescribing generics over brand-name drugs could save billions of dollars

Over a 2-year period, the researchers estimated that the United States could have saved $73 billion by prescribing generic equivalents.

Metformin more effective than sulfonylureas for reducing cardiovascular mortality in diabetes patients

Metformin more effective than sulfonylureas for reducing cardiovascular mortality in diabetes patients

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Compared with other drugs for type 2 diabetes, metformin is superior for reducing the risk of cardiovascular mortality.

Use of potentially lethal drug combinations increases in the elderly

Use of potentially lethal drug combinations increases in the elderly

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The rates of dangerous drug combinations, supplement use, and polypharmacy are increasing among older adult patients.

Drug combos not more effective than naproxen alone for acute low back pain

Drug combos not more effective than naproxen alone for acute low back pain

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When compared to naproxen alone, the combination of either cyclobenzaprine or oxycodone/acetaminophene plus naproxen does not as effectively improve acute, nontraumatic lower back pain.

American College of Physicians recommends prescribing generic medications

American College of Physicians recommends prescribing generic medications

Clinicians should prescribe generic medications over brand-name drugs when they can because the generics are less expensive and molecularly identical.

Grapefruit-drug interactions


Grapefruit-drug interactions


Grapefruit can safely be consumed with the majority of medications, and patients with concerns should consult with their physicians.

Prescription use common in pregnant women with Medicaid

Prescription use common in pregnant women with Medicaid

Pregnant women enrolled in Medicaid are commonly prescribed a variety of prescription medications.

Integrative and OTC treatment of headache

Integrative and OTC treatment of headache

Headache is one of the most common complaints in outpatient practice. There are 10 things that clinicians need to know to help treat their patients with headache.

Heart attack, stroke warnings updated for NSAIDs

Heart attack, stroke warnings updated for NSAIDs

The FDA will require manufacturers to include updated warnings on prescription and OTC NSAIDs.

In menopausal women, SSRIs increase fracture risk

In menopausal women, SSRIs increase fracture risk

Women prescribed SSRIs for menopausal symptoms had a sustained increased risk for fracture.

Fewer adverse outcomes when pharmacists manage warfarin therapy

Fewer adverse outcomes when pharmacists manage warfarin therapy

Patients whose warfarin therapy was managed by pharmacists had reduced adverse outcomes compared with usual care.

Grapefruit contraindicated with increasing numbers of drugs

Grapefruit contraindicated with increasing numbers of drugs

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Take thorough dietary histories to be sure patients are not taking medications that adversely interact with the fruit.

Statin discontinuation may increase quality of life in patients with life-limiting illness

Statin discontinuation may increase quality of life in patients with life-limiting illness

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Patients with life-limiting illnesses often take statins, and discontinuing these can increase quality of life.

Psychotropic medication use in children

Psychotropic medication use in children

Whether to prescribe psychotropic medications in children with anxiety and sleep disorders is a common ethical dilemma faced by primary care providers.

Male with symptomatic
 benign prostatic hyperplasia


Male with symptomatic
 benign prostatic hyperplasia


Several pharmaceutical options exist for men with symptomatic benign prostatic hyperplasia who cannot tolerate alpha blockers.

Sam's Club savings program now offers low-cost Alzheimer, diabetes medications

Sam's Club savings program now offers low-cost Alzheimer, diabetes medications

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More than 200 generic medications are available for $4 and more than 400 generic prescriptions are available for $10.

Keeping an accurate 
medication list is critical 
to a patient's care


Keeping an accurate 
medication list is critical 
to a patient's care


Educating patients can help them see the importance of having an accurate medication list.

Experts question safety of acetaminophen

Experts question safety of acetaminophen

Heavy use of acetaminophen is associated with kidney disease and bleeding in the digestive tract.

Patients may be mixing medications with alcohol

Patients may be mixing medications with alcohol

Nearly 42% of patients considered current drinkers reported taking a medication that can interact with alcohol.

Results of medicine-adherence interventions inconsistent

Results of medicine-adherence interventions inconsistent

More research needs to be done in order to demonstrate the effectiveness of interventions designed to improve patient adherence to prescribed medications.

Stopping selective serotonin reuptake inhibitors does not cut miscarriage risk

Stopping selective serotonin reuptake inhibitors does not cut miscarriage risk

Increased miscarriage risk has been observed in both female patients who have been exposed to selective serotonin reuptake inhibitors (SSRIs) and patients who discontinued use.

High-dose aspirin still prescribed after myocardial infarction

High-dose aspirin still prescribed after myocardial infarction

Although data suggests low-dose aspirin offers similar results without the risk of bleeding, high-dose aspirin is still more commonly prescribed.

FDA approves extended-release painkiller

FDA approves extended-release painkiller

The medication is designed to deter abuse of the drug by snorting or injection.

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