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PHOSPHOLINE IODIDE
Glaucoma
Miscellaneous ocular agents
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Drug Name:

PHOSPHOLINE IODIDE Rx

Generic Name and Formulations:
Ecothiophate iodide 0.125%; oph soln.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for PHOSPHOLINE IODIDE:

Reduction of elevated intraocular pressure (IOP).

Adult:

1 drop twice daily, in the AM and at bedtime (1 drop once daily or every other day have been used). Apply finger pressure to inner canthus for 1–2mins after instillation.

Children:

Not applicable.

Contraindications:

Active uveal inflammation. Angle-closure glaucoma without iridectomy.

Warnings/Precautions:

Discontinue or withhold if cardiac irregularities, salivation, urinary incontinence, diarrhea, profuse sweating, muscle weakness, or respiratory difficulties occur. Vagotonia. Bronchial asthma. Spastic GI disturbances. Peptic ulcer. Pronounced bradycardia. Hypotension. Recent MI. Epilepsy. Parkinsonism. History of retinal detachment. Pregnancy. Nursing mothers: not recommended.

Pharmacological Class:

Cholinesterase inhibitor.

Interactions:

Caution with other cholinesterase inhibitors (eg, succinylcholine, organophosphate and carbamate insecticides); additive effects.

Adverse Reactions:

Stinging, burning, lacrimation, lid muscle twitching, conjunctival and ciliary redness, browache, induced myopia, visual blurring, activation of latent iritis, uveitis, iris cysts (esp. in children), conjunctival thickening, obstruction of nasolacrimal canals, lens opacities, retinal detachment, paradoxical increase in IOP, cardiac irregularities.

How Supplied:

Soln—5mL (w. diluent + dropper)

Indications for PHOSPHOLINE IODIDE:

Concomitant esotropias with a significant accommodative component.

Adult:

Not applicable.

Children:

Diagnosis: 1 drop once daily in both eyes at bedtime for a period of 2 or 3 weeks. Treatment: after diagnostic period, reduce to 1 drop once every other day; usual max: 1 drop once daily. Apply finger pressure to inner canthus for 1–2mins after instillation.

Contraindications:

Active uveal inflammation. Angle-closure glaucoma without iridectomy.

Warnings/Precautions:

Discontinue or withhold if cardiac irregularities, salivation, urinary incontinence, diarrhea, profuse sweating, muscle weakness, or respiratory difficulties occur. Vagotonia. Bronchial asthma. Spastic GI disturbances. Peptic ulcer. Pronounced bradycardia. Hypotension. Recent MI. Epilepsy. Parkinsonism. History of retinal detachment. Pregnancy. Nursing mothers: not recommended.

Pharmacological Class:

Cholinesterase inhibitor.

Interactions:

Caution with other cholinesterase inhibitors (eg, succinylcholine, organophosphate and carbamate insecticides); additive effects.

Adverse Reactions:

Stinging, burning, lacrimation, lid muscle twitching, conjunctival and ciliary redness, browache, induced myopia, visual blurring, activation of latent iritis, uveitis, iris cysts (esp. in children), conjunctival thickening, obstruction of nasolacrimal canals, lens opacities, retinal detachment, paradoxical increase in IOP, cardiac irregularities.

How Supplied:

Soln—5mL (w. diluent + dropper)

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