Generic Name and Formulations:
Atenolol, chlorthalidone; 50mg/25mg+, 100mg/25mg; tabs; (+) scored.
Indications for TENORETIC:
Switching from monotherapy: initially one 50mg/25mg tab daily; may increase to one 100mg/25mg tab daily. CrCl 15–35mL/minute: max 50mg atenolol/day. CrCl <15mL/minute: max 50mg atenolol every other day.
Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock. Anuria. Sulfonamide allergy. Pregnancy (Cat.D).
Heart failure. Bronchospastic disease. Renal or hepatic dysfunction. SLE. Gout. Diabetes. Asthma. Hyperthyroidism. Hypokalemia. Surgery. Postsympathectomy. Peripheral circulatory disorders. Avoid abrupt cessation. Monitor electrolytes. Excessive diuresis. Potassium supplementation may be needed. Nursing mothers: not recommended.
May potentiate hypotension with prazosin, alcohol, catecholamine-depleting drugs, CNS depressants. May increase toxicity of diazoxide, digitalis, lithium. Conduction abnormalities, bradycardia, heart block with calcium channel blockers (esp. verapamil, diltiazem). Adjust antidiabetic medications. Increased rebound hypertension with clonidine withdrawal. May block epinephrine. May increase responsiveness to tubocurarine. ACTH, steroids, amphotericin B increase risk of hypokalemia.
Cardioselective beta-blocker + diuretic.
Heart failure, bronchospasm, bradycardia, heart block, dizziness, fatigue, fluid or electrolyte imbalance, hyperuricemia, orthostatic hypotension, GI upset, cold extremities.