Olaparib Treatment May Improve Health-Related Quality of Life in Germline BRCA1/2-Mutated Ovarian CancerSeptember 10, 2018
Olaparib, may help to improve duration of good quality of life and quality-adjusted progression-free survival in germline BRCA1/2-mutated ovarian cancer.
Overall response of platelet count 50,000/L seen in 43% of patients.
Transcranial magnetic stimulation (TMS) uses magnetic fields to stimulate nerve cells in the brain.
Lower degree of susceptibility to ibalizumab for 9 of 10 patients with virology failure, rebound.
A systematic literature review, published in Clinical Infectious Diseases, found no evidence supporting a benefit to antibacterial therapy for osteomyelitis in patients with stage IV sacral pressure ulcers.
Oral administration of BCX7353 at dose of 125 mg results in lower rate of attacks vs placebo.
Rifampin has significantly higher rate of treatment completion, fewer drug-related adverse events.
As fecal microbiota transplantation has been found to be effective in treating a number of gastrointestinal diseases, such as Clostridium difficile infection, researchers are now assessing whether it may also be effective for patients with irritable bowel syndrome.
Nemolizumab Effective for Moderate, Severe Atopic Dermatitis Inadequately Controlled With Topical TherapyJuly 30, 2018
For patients with moderate to severe atopic dermatitis inadequately controlled with topical therapies, the anti-IL-31 receptor A humanized monoclonal antibody nemolizumab may provide benefit.
ART recommended for almost all HIV-infected; should be initiated as soon as possible post diagnosis.
Compared with human neutral protamine Hagedorn insulin, basal insulin analogs do not reduce risk of hypoglycemia-linked ED visits or hospital admissions in T2D.
L-Glutamine oral treatment with or without hydroxyurea reduces pain crises better than placebo in individuals with sickle cell disease.
Single high-dose liposomal amphotericin B (L-AmB) is non-inferior to daily dosed L-AmB at the standard dose in treatment of fungal clearance in HIV-associated cryptococcal meningitis.
A study was conducted to evaluate the oxazolidinone resistance mechanisms of enterococci bacteria.
First-line chemotherapy in combination with bevacizumab, compared with chemotherapy alone, may benefit patients with ovarian cancer and elevated neutrophil-to-lymphocyte ratios.
Study patients who received Avastin plus chemotherapy followed by Avastin alone, had a greater median PFS vs patients who received chemotherapy alone (18.2 months vs 12 months; hazard ratio [HR] 0.62, 95% CI, 0.52-0.75; P<.0001).
Valve has been approved after review of data from trial involving 190 patients with emphysema
Mirvetuximuab soravtansine uses a humanized FRα-binding antibody to target antibody-drug conjugates specifically to FRα-expressing cancer cells and a potent anti-tumor agent, DM4, to kill the targeted cancer cells.
DBS has been known to generate other movement-related disorders such as dyskinesias, blepharospasm, and hypokinesia.
The final analysis set comprised biologic-naïve individuals — individuals who had filled an initial prescription for etanercept, infliximab, adalimumab, or ustekinumab after 2 years without using any biologic agent during the study period.
In patients with and without dementia, amyloid-positive and negative results were significantly linked to diagnoses and treatment changes.
Researchers conducted a retrospective matched cohort study to compare the risk of death among BPH patients treated with 5ARIs, as monotherapy or in combination with alpha-blockers, and those treated with alpha-blockers alone.
In 2003, the Human Genome Project became the culmination of the history of genetics research, allowing us to understand the role of genetics in human health and disease. As part of The Clinical Advisor's 20th Anniversary, this article explores the influence of race and genetics in clinical practice.
Patients with mild, moderate renal impairment showed improvement in renal biomarkers over one year
Microneedling combined with bleomycin was associated with higher clearance rates and was less painful than the use of intralesional bleomycin injections.
In patients with mild asthma, use of the inhaled combined corticosteroid and beta agonist budesonide-formoterol as needed was superior to terbutaline as needed with respect to electronically recorded weeks of well-controlled asthma.
Oral medication, botulinum toxin type A injections, and endoscopic decompression surgery were all compared in the treatment of patients with frontal secondary headaches due to STN and SON configuration.
Payments correlated with prescribing opioids in 2014 may have influenced the increased prescription rates of 2015.
Researchers found a positive but weak correlation between psychological interventions and chronic pain treatment in older adults.
But majority of oncologists don't feel knowledgeable enough to make these recommendations