Treatments

Single High-Dose Liposomal Amphotericin B Effectively Treats HIV-Associated Cryptococcal Meningitis

Single High-Dose Liposomal Amphotericin B Effectively Treats HIV-Associated Cryptococcal Meningitis

Single high-dose liposomal amphotericin B (L-AmB) is non-inferior to daily dosed L-AmB at the standard dose in treatment of fungal clearance in HIV-associated cryptococcal meningitis.

Is New Surveillance Monitoring Required for Enterococcal Oxazolidinone Resistance?

Is New Surveillance Monitoring Required for Enterococcal Oxazolidinone Resistance?

A study was conducted to evaluate the oxazolidinone resistance mechanisms of enterococci bacteria.

Chemotherapy With Bevacizumab May Improve Some Ovarian Cancer Outcomes, Worsen Others

Chemotherapy With Bevacizumab May Improve Some Ovarian Cancer Outcomes, Worsen Others

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First-line chemotherapy in combination with bevacizumab, compared with chemotherapy alone, may benefit patients with ovarian cancer and elevated neutrophil-to-lymphocyte ratios.

Avastin Plus ChemoTx Approved for Advanced Ovarian Cancer After Resection

Avastin Plus ChemoTx Approved for Advanced Ovarian Cancer After Resection

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Study patients who received Avastin plus chemotherapy followed by Avastin alone, had a greater median PFS vs patients who received chemotherapy alone (18.2 months vs 12 months; hazard ratio [HR] 0.62, 95% CI, 0.52-0.75; P<.0001).

FDA: Zephyr Endobronchial Valve Approved for Severe Emphysema

FDA: Zephyr Endobronchial Valve Approved for Severe Emphysema

Valve has been approved after review of data from trial involving 190 patients with emphysema

Mirvetuximab Gets Fast Track Status for Platinum-Resistant Ovarian Cancer

Mirvetuximab Gets Fast Track Status for Platinum-Resistant Ovarian Cancer

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Mirvetuximuab soravtansine uses a humanized FRα-binding antibody to target antibody-drug conjugates specifically to FRα-expressing cancer cells and a potent anti-tumor agent, DM4, to kill the targeted cancer cells.

Weighing the Risks of Deep Brain Stimulation

Weighing the Risks of Deep Brain Stimulation

DBS has been known to generate other movement-related disorders such as dyskinesias, blepharospasm, and hypokinesia.

Psoriasis Treatment With Biologics Often Requires Multiple Courses, Treatment Changes

Psoriasis Treatment With Biologics Often Requires Multiple Courses, Treatment Changes

The final analysis set comprised biologic-naïve individuals — individuals who had filled an initial prescription for etanercept, infliximab, adalimumab, or ustekinumab after 2 years without using any biologic agent during the study period.

Diagnosis, Treatments Affected by Amyloid Results in Dementia, Nondementia Patients

Diagnosis, Treatments Affected by Amyloid Results in Dementia, Nondementia Patients

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In patients with and without dementia, amyloid-positive and negative results were significantly linked to diagnoses and treatment changes.

Mortality Risk Compared Among Men Receiving Drug Therapy for BPH/LUTS

Mortality Risk Compared Among Men Receiving Drug Therapy for BPH/LUTS

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Researchers conducted a retrospective matched cohort study to compare the risk of death among BPH patients treated with 5ARIs, as monotherapy or in combination with alpha-blockers, and those treated with alpha-blockers alone.

A History of Race and the Emerging Role of Genetics in Primary Care

A History of Race and the Emerging Role of Genetics in Primary Care

In 2003, the Human Genome Project became the culmination of the history of genetics research, allowing us to understand the role of genetics in human health and disease. As part of The Clinical Advisor's 20th Anniversary, this article explores the influence of race and genetics in clinical practice.

Sofosbuvir Improves Renal Safety in Patients With Chronic Hepatitis C

Sofosbuvir Improves Renal Safety in Patients With Chronic Hepatitis C

Patients with mild, moderate renal impairment showed improvement in renal biomarkers over one year

Microneedling Plus Bleomycin Spraying Superior for Plantar Wart Treatment

Microneedling Plus Bleomycin Spraying Superior for Plantar Wart Treatment

Microneedling combined with bleomycin was associated with higher clearance rates and was less painful than the use of intralesional bleomycin injections.

Budesonide-formoterol as needed superior to terbutaline in mild asthma: The SYGMA trial

In patients with mild asthma, use of the inhaled combined corticosteroid and beta agonist budesonide-formoterol as needed was superior to terbutaline as needed with respect to electronically recorded weeks of well-controlled asthma.

Patients with Frontal Chronic Headaches May Benefit from Endoscopic Decompression Surgery

Patients with Frontal Chronic Headaches May Benefit from Endoscopic Decompression Surgery

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Oral medication, botulinum toxin type A injections, and endoscopic decompression surgery were all compared in the treatment of patients with frontal secondary headaches due to STN and SON configuration.

Pharmaceutical Marketing Associated With Increased Opioid Prescription Rates

Pharmaceutical Marketing Associated With Increased Opioid Prescription Rates

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Payments correlated with prescribing opioids in 2014 may have influenced the increased prescription rates of 2015.

Psychological Interventions Beneficial for Chronic Pain in Older Adults

Psychological Interventions Beneficial for Chronic Pain in Older Adults

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Researchers found a positive but weak correlation between psychological interventions and chronic pain treatment in older adults.

Many Oncologists Discuss, Recommend Medical Marijuana

Many Oncologists Discuss, Recommend Medical Marijuana

But majority of oncologists don't feel knowledgeable enough to make these recommendations

Ovarian Cancer Patients May Benefit From Trabectedin With PLD

Ovarian Cancer Patients May Benefit From Trabectedin With PLD

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For patients with platinum-sensitive recurrent ovarian cancer, trabectedin plus PLD may be beneficial.

Highly Selective, First-in-Class CDK4 Inhibitor Promising in Ovarian Cancer

Highly Selective, First-in-Class CDK4 Inhibitor Promising in Ovarian Cancer

Mice treated with 2-94 had few or no signs of lymphopenia or neutropenia, common adverse events associated with palbociclib.

FDA Targets Clinics Offering Unapproved Stem Cell Therapies

FDA Targets Clinics Offering Unapproved Stem Cell Therapies

Clinics claim unapproved therapies can treat number of diseases and conditions, including ALS and cancer

Vigil Immunotherapy and PARP 7 Treatments for Patients with Ovarian Cancer

Vigil Immunotherapy and PARP 7 Treatments for Patients with Ovarian Cancer

Vigil immunotherapy is possible for women with recurrent ovarian cancer and PARP 7 may impact ovarian cancer survival, according to two studies presented in New Orleans.

Allergic response in patients with chronic rhinosinusitis and nasal polyposis

Allergic response in patients with chronic rhinosinusitis and nasal polyposis

Researchers assessed the use of dupilumab in adults with chronic rhinosinusitis and nasal polyps who did not respond to treatment with intranasal corticosteroids.

Early dermatology consultation linked to improved diagnostic accuracy and care in cellulitis

Among patients admitted to the hospital for a provisional diagnosis of cellulitis, early dermatologic consultation was associated with improved recognition of pseudo-cellulitis, decreased antibiotic use, and earlier discharge.

Ovarian cancer patients may benefit from added hyperthermic intraperitoneal chemotherapy

Ovarian cancer patients may benefit from added hyperthermic intraperitoneal chemotherapy

The addition of HIPEC resulted in longer recurrence-free and overall survival among patients with ovarian cancer.

Glucocorticoid treatment ineffective for reducing sepsis-related mortality

Glucocorticoid treatment ineffective for reducing sepsis-related mortality

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Hydrocortisone treatment does not effectively reduce mortality in sepsis.

Novel device may ease symptoms of tinnitus

Novel device may ease symptoms of tinnitus

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Bimodal auditory-somatosensory treatment is noninvasive and showed no side effects.

FDA approves new hemophilia A drug with factor VIII inhibitors

FDA approves new hemophilia A drug with factor VIII inhibitors

New FDA-approved prophylactic treatment decreases bleeding episodes hemophilia A patients with factor VIII inhibitors.

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