Adiposity, weight gain up type 2 diabetes risk in patients with gestational diabetes
Adiposity, weight gain up T2D risk in patients with GDM
HealthDay News — For women with gestational diabetes mellitus, baseline and most recent body mass index and weight gain after gestational diabetes mellitus correlate with increased long-term risk of developing type 2 diabetes, according to a study published in Diabetologia.
To examine how adiposity and weight change influence the long-term risk of developing type 2 diabetes after gestational diabetes mellitus (GDM), Wei Bao, MD, PhD, of the National Institutes of Health in Rockville, Md., and colleagues followed 1,695 patients with incident GDM between 1991 and 2001.
During 18 years of follow-up, the researchers identified 259 incident cases of type 2 diabetes. For each 1 kg/m² increase in body mass index (BMI), the adjusted hazard ratio for type 2 diabetes was 1.16 for baseline BMI and 1.16 for most recent BMI.
Each 5 kg increment of weight gain after GDM development correlated with an increased risk of type 2 diabetes (adjusted hazard ratio, 1.27). Compared with women who had a BMI of <25 kg/m² and gained <5 kg after GDM, women with a BMI of ≥30 kg/m² at baseline and who gained ≥5 kg after GDM had an adjusted hazard ratio of 43.19 for type 2 diabetes.
“Our findings provide evidence to support the recent call from National Diabetes Education Program and highlight the importance of achieving and maintaining a healthy weight in these high-risk women to prevent future development of type 2diabetes,” concluded the scientists.