Gas, dust, and fume exposure increases mite sensitization risk

Gas, dust, and fume exposure increases mite sensitization risk
Gas, dust, and fume exposure increases mite sensitization risk

HealthDay News -- Work-related exposure to gas, dust, and fumes ups the risk of mite sensitization, and is associated with asthma and wheeze in patients who are mite-sensitized, according to research published in Allergy.

To examine the role of sensitization in the correlation between gas, dust, and fumes and allergic conditions, Anders Bjerg, MD, PhD, of the University of Gothenburg in Sweden, and colleagues used data from questionnaires and skin prick tests from a population-based sample of 788 adult patients who were part of the West Sweden Asthma Study.

Gas, dust, and fume exposure correlated with a doubled risk of sensitization to mites, but not other allergens, the investigators found after adjusting for confounders. The effect of gas, dust, and fumes on asthma was modified by mite sensitization. Gas, dust, and fumes correlated with clinician-diagnosed asthma and wheeze in mite-sensitized patients (adjusted odds ratio, 2.9 and 2.4, respectively).

The corresponding odds ratios were 1.1 and 0.6 in non-mite-sensitized subjects. Irrespective of mite sensitization, gas, dust, and fumes were independently associated with eczema but not rhinitis.

"These novel findings suggest that components of gas, dust, and fumes may act as adjuvants that facilitate sensitization to mites, and that mite-sensitized individuals may be especially susceptible to inhalant occupational exposures," concluded the authors.

References

  1. Bjerg A et al. Allergy. 2015; doi: 10.1111/all.12584
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