HIV increases coronary artery disease risk

Coronary artery plaque is more prevalent and extensive in HIV-infected men.

HIV increases coronary artery disease risk
HIV increases coronary artery disease risk

HealthDay News -- Men who are infected with HIV are at greater risk of coronary artery disease (CAD), according to researchers.

Wendy S. Post, MD, of the Johns Hopkins University School of Medicine and Bloomberg School of Public Health in Baltimore, and colleagues performed noncontrast cardiac computed tomography (CT) scans and CT angiography in HIV-infected men (n=618) and uninfected men (n=383), aged 40 to 70 years, with no history of coronary revascularization.

After multivariable adjustment, the prevalence of coronary artery calcium (CAC) was greater in HIV-infected men than in uninfected men (prevalence ratio, 1.21; 95% CI: 1.08-1.35; P=0.001), the researchers reported in Annals of Internal Medicine.

CT angiography showed greater prevalence of plaque in HIV-infected men than in uninfected men, including any plaque, noncalcified plaque and mixed plaque. After CAD risk factor adjustment, the associations between HIV infection and any plaque or noncalcified plaque remained significant.

Factors associated with coronary stenosis greater than 50% included longer duration of highly active antiretroviral therapy (PR, 1.09; 95% CI: 1.02-1.17; P=0.007) and lower nadir CD4+ T-cell count (PR, 0.80; 95% CI: 0.69-0.94; P=0.005).

"This study supports the hypothesis that HIV infection or its treatment increases the risk for coronary artery disease," the researchers wrote.

References

  1. Post WS et al. Ann Intern Med. 2014;160(7):458-467.
  2. Currier JS et al. Ann Intern Med. 2014; 160(7):509-510.
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