Intensive tx doesn't reduce long-term diabetes complications

Multifactorial management did not significantly reduce frequency of microvascular complications in type 2 diabetes patients.

No benefit on long-term diabetes complications with intensive treatment
No benefit on long-term diabetes complications with intensive treatment

HealthDay News -- Compared with routine care, early intensive multifactorial therapy did not result in better microvascular outcomes at five years among individuals with screening-detected diabetes, according to researchers.

To assess the effect of treatment type on microvascular complications, Annelli Sandbaek, MD, PhD, and colleagues followed 2,861 patients with type 2 diabetes assigned to intensive treatment or routine care. The findings were published in Diabetes Care.

Of patients who received intensive treatment, 22.7% had any type of albuminuria, compared with 24.4% in patients undergoing routine care (odds ratio 0.87; 95% CI: 0.72-1.07).

Retinopathy occurred in 10.2% of intensive treatment patients versus 12.1% in routine care patients (OR, 0.84; 95% CI: 0.64-1.10). Neuropathy was found in 4.9% and 5.9%, respectively (OR, 0.95; 95% CI: 0.68-1.34).

Between baseline and follow-up, estimated glomerular filtration rate increased in both groups (4.31 and 6.44 mL/min in the intensive treatment and routine care groups, respectively).

"Compared with routine care, an intervention to promote target-driven, intensive management of patients with type 2 diabetes detected by screening was not associated with significant reductions in the frequency of microvascular events at five years," wrote the researchers.

References

  1. Sandbaek A et al. Diabetes Care. 2014; doi: 10.2337/dc13-1544
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