No benefit to delaying next pregnancy attempt after early loss

Couples conceiving within the 0- to 3-month interval are more likely to achieve live birth.
Couples conceiving within the 0- to 3-month interval are more likely to achieve live birth.

HealthDay News — For couples with early pregnancy loss, there is no indication of improved live birth rates with delayed next attempt at pregnancy, according to a study published in the February issue of Obstetrics & Gynecology.

Karen C. Schliep, PhD, from the Eunice Kennedy Shriver National Institute of Child Health and Human Development in Bethesda, Md., and colleagues compared time to pregnancy and live birth among couples with varying intervals of pregnancy loss date to subsequent trying to conceive date. Data were included for 1,083 women aged 18 to 40 years with one to two prior early losses and whose last pregnancy outcome was a nonectopic or nonmolar loss. Participants were followed for up to six menstrual cycles.

The researchers found that, compared to couples with a greater than three-month interval, couples with a zero- to three-month interval were more likely to achieve live birth (53.2% versus 36.1%), with a significantly shorter time to pregnancy leading to live birth (median, five cycles; adjusted fecundability odds ratio, 1.71). The estimates were not appreciably altered after adjustment for low-dose aspirin treatment.

"Our study supports the hypothesis that there is no physiologic evidence for delaying pregnancy attempt after an early loss," the authors write.

Reference

  1. Schliep KC, Mitchell EM, Mumford SL, et al. Trying to conceive after an early pregnancy loss: An assessment on how long couples should wait. Obstet Gynecol. 2016; doi: 10.1097/AOG.0000000000001159\
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