Psoriasis linked to increased chronic kidney disease, glomerulonephritis risk

Psoriasis may up CKD, GN risk
Psoriasis may up CKD, GN risk

HeathDay News -- Psoriasis is associated with a higher risk of developing chronic kidney disease (CKD) and glomerulonephritis (GN), according to a study published in the British Journal of Dermatology.

To identify the association between the risk of CKD, GN, and psoriasis, H.-Y. Chiu, of the National Taiwan University in Taipei, and colleagues identified 4,344 patients with psoriasis for the study cohort and randomly selected 13,032 patients to serve as controls. Each subject was followed for five years to identify subsequent development of GN and CKD.

Psoriasis was independently associated with an increased risk of CKD during the follow-up period (hazard ratio [HR], 1.28), after adjusting for traditional CKD risk factors.

The association may be partly explained by the increased incidence of GN in psoriasis patients (HR, 1.50). The increased risk of CKD and GN was seen in patients with both mild and severe psoriasis, compared with the control cohort.

The risk increased with severity. Psoriasis patients with arthritis had a higher risk of CKD compared to patients without arthritis (HR, 1.62 and 1.26, respectively). Nonsteroidal anti-inflammatory drugs (NSAIDs) had the strongest association of any medications with CKD in patients with psoriasis (adjusted odds ratio, 1.69).

"High severity, psoriatic arthritis involvement, and concomitant NSAID use further increased the risk of CKD in patients with psoriasis,” concluded the researchers.

References

  1. Chiu HY et al. The British Journal of Dermatology. 2014; doi: DOI: 10.1111/bjd.13599

Disclosures

One author disclosed financial ties to the pharmaceutical industry.

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