Interrelationship Between Celiac Disease, Self-Reported Wheat Sensitivity, and Functional GI Disorders
Individuals with clinically diagnosed celiac disease are at greater risk for chronic gastrointestinal symptoms, possibly fitting modified Rome criteria for irritable bowel syndrome and functional dyspepsia.
Fidaxomicin demonstrated the strongest evidence for being the most effective treatment in providing a long-term cure for C difficile infection.
Causes of death in patients with epilepsy were assessed to determine the presence of cardiac pathology.
The use of multiple sun protection measures was defined as the use of 2 or more of these measures more than 50% of the time when the individual was outdoors.
Exemption from vaccination is common in Arizona school districts due to lack of trust in medical establishments.
Respiratory symptoms were more common in older children compared with infants who presented with food-induced anaphylaxis.
Women with preeclampsia with severe features had increased right ventricular systolic pressure and decreased global right ventricular longitudinal systolic strain.
The relationship between bullous pemphigoid and dipeptidyl peptidase-4 inhibitors in type 2 diabetes.
Single high-dose liposomal amphotericin B (L-AmB) is non-inferior to daily dosed L-AmB at the standard dose in treatment of fungal clearance in HIV-associated cryptococcal meningitis.
Therapy Focusing on Mindfulness, Interoception Improves Outcomes for Women With Substance Use Disorder
These findings are consistent with emerging neurocognitive models linking interoception to emotion regulation and related health outcomes, providing valuable input in improving substance use disorder treatment.
The Endocrine Society, European Society of Endocrinology, and Pediatric Endocrine Society issue guidelines for the management of hypothalamic-pituitary and growth disorders in childhood cancer survivors.
First-line chemotherapy in combination with bevacizumab, compared with chemotherapy alone, may benefit patients with ovarian cancer and elevated neutrophil-to-lymphocyte ratios.
American emergency medicine physicians have been taking measures to address the ongoing opioid crisis, which affects emergency departments throughout the country.
Radiofrequency denervation, typically used to treat lumbar and cervical zygapophyseal joint pain, has shown efficacy in treating thoracic zygapophyseal joint pain.
A study was conducted to evaluate the oxazolidinone resistance mechanisms of enterococci bacteria.
An analysis of population data on cancer incidence, survival, and mortality revealed that early interventions and improvements to treatments contributed to a 26% decline in cancer deaths from 1991 to 2015.
No significant difference was identified in combination CA125/CEA ratio vs CEA alone in distinguishing ovarian neoplasms from ovarian metastases.
Study patients who received Avastin plus chemotherapy followed by Avastin alone, had a greater median PFS vs patients who received chemotherapy alone (18.2 months vs 12 months; hazard ratio [HR] 0.62, 95% CI, 0.52-0.75; P<.0001).
Investigators examined rates, predictors, and outcomes of neuroimaging in pediatric and adolescent patients who presented to the ED with a headache.
Differences Between Cyclothymic Disorder and Unspecified Bipolar Disorder in Youth May Indicate Course of Disorder
Investigators sought to determine the differences between youth with cyclothymic disorder and bipolar disorder not otherwise specified.
Consensus guidelines regarding the use of ketamine for the management of acute pain have been approved.
Siblings of patients with rheumatoid arthritis appear to have an increased risk for acute coronary syndrome, which suggests there is a shared susceptibility between the 2 conditions.
The administration of PCV7 and PCV13 reduced the number of ambulatory visits for otitis media in pediatric patients.
This retrospective study sought to assess migraine patterns in 69 menopausal women between ages 40 and 60 who were treated at Partners Healthcare Hospitals for concurrent migraine headache.
These data show that ASD may arise from an early neurobiological difference in response to rewarding social stimuli, which could result in reduced social motivation.
Thinning of the retinal nerve fiber layer has been linked to worsening cognitive function and may be valuable in identifying individuals who may be at risk for cognitive decline.
The recall affects approximately 470,000 units that include drugs packaged with 3 to 10 tablets per blister card. The blister packs were developed for use in hospitals, however some were sent to retail pharmacies and were likely dispensed for in-home use.
A panel discussion event held at the US Food and Drug Administration gathered patients with chronic pain and FDA officials, to reconcile concerns around prescriptions of opioid medications with the needs of these patient populations.
Women prescribed long- vs short-term opioids for chronic musculoskeletal pain may be at increased risk for menopause and abnormal menstruation.
Mirvetuximuab soravtansine uses a humanized FRα-binding antibody to target antibody-drug conjugates specifically to FRα-expressing cancer cells and a potent anti-tumor agent, DM4, to kill the targeted cancer cells.
Patients with type 2 diabetes who were initially treated with multiple daily injections were assessed before and after switching to continuous subcutaneous insulin infusion.
Results - including the date you were checked and a list of what you were checked for - can be shared by users through text, e-mail or on dating profiles.
Using state- and individual-level data from the 1995-2014 National Immunization Survey, the effect of a state's Universal Purchase adoption on vaccination rates was estimated.
Others have argued that dismissal is ethically problematic because it can deprive children of comprehensive pediatric care and undermine public health.
Adherence and completion to multidose vaccine schedules for hepatitis A, B, and A-B are low, thereby rendering vaccination ineffective.
Researchers from the University of Bristol found no association between 25-hydroxyvitamin D level and pregnancy-related hypertensive disorders.
Social media is an ideal platform to reach teenagers and young adults to encourage sun safety.
Cirrhosis is associated with an increased risk for diabetes mellitus among patients living with HIV.
In adults with sickle cell disease, higher daily opioid use may be associated with poorer health-related quality of life.
Investigators examined renal outcomes when controlling cardiovascular risk factors, such as blood pressure, LDL-C, and HbA1c.
Hormone therapy in postmenopausal women with mild cognitive impairment was examined.
Investigators analyzed real world data to examine the risk for below-knee amputations in patients with type 2 diabetes taking canagliflozin vs other medications.
Investigators examined the relationship between the use of β-blockers and incidence of hypoglycemia and risk for mortality in hospitalized patients with diabetes.
Investigators compared 2 methods of delivering bolus insulin, pen vs patch, using metrics from continuous glucose monitoring.
Researchers assessed whether current metabolic parameters are inversely associated with cognitive functioning.
Investigators examined the efficacy of liraglutide for the prevention of dementia in elderly patients with type 2 diabetes.
Investigators examined the effectiveness of oral agents vs insulin as an initial treatment option for people newly diagnosed with type 2 diabetes.
Investigators examined cardiovascular outcomes in patients with elevated triglyceridemia and diabetes treated with statins.
A literature review revealed that the use of care navigators in conjunction with follow-up telephone calls from nursing staff improved transition of care and readmission rates in patients with congestive heart failure.
Hospitalist NPs are key to successfully implementing Society of Hospital Medicine guidelines for preoperative testing and management.
An evaluation assessed the nonhealthcare-related influences that have led to misconceptions about long-acting reversible contraceptives.
Nurse educators may not be fully prepared to teach students about transgender patient care.
Project ECHO at Los Angeles Christian Health Center contributes to improved care of HCV in underserved populations.
Investigators report results from the MONALEESA-7 trial, which assessed ribociclib plus endocrine therapy in premenopausal women with advanced breast cancer.
Lofexidine may help patients with opioid withdrawal symptoms or difficulty with opioid discontinuation.
In children with type 1 diabetes, the Omnipod hybrid closed-loop personal model system was safe and performed well.
Investigators examined the incidence and outcomes of pneumonia in patients with acute ischemic stroke and type 2 diabetes.
The ITCA 650, a small titanium osmotic mini-pump, provides a subcutaneous infusion of exenatide over 3 or 6 months.
MEDI0382 reduced body weight and normalized fasting and postprandial blood glucose levels in patients with type 2 diabetes.
Investigators examined the prevalence of chronic kidney disease in adults with type 1 diabetes compared with type 2 diabetes.
The safety assessment included incidence of insertion or procedure-related removal and device-related serious adverse events through 180 after insertion.
Incidental abnormalities are most frequently observed in computed tomography colonoscopy, computed tomography of the chest, and cardiac magnetic resonance imaging.
A study assessing the impact of upscheduling of hydrocodone combined medications on APRN practices in Oklahoma revealed significant barriers to effective pain management.
Researchers deployed a survey to individuals who had received treatment for opioid use disorder to assess their use of buprenorphine.
The phase 3 SUMMIT-07 trial assessed the safety, efficacy, and tolerability of a new mu-opioid receptor agonist analgesic in adults with moderate to severe chronic lower back pain.
Patients receiving treatment with antipsychotic agents would benefit from screening for tardive dyskinesia as these repetitive movements can negatively affect quality of life.
Investigators assessed the potential for abuse associated with NKTR-181, a new mu-opioid receptor agonist analgesic.
A combination of naltrexone induction and psychoeducational counseling was found to facilitate transition from active opioid use and buprenorphine maintenance in individuals with opioid use disorder.
From 2007 to 2015, the majority of initial hepatitis A, B, and A/B vaccinations were administered by primary care providers.
The 2017-2018 influenza season in the United States (October 1, 2017-May 19, 2018) was a high-severity season.
The use of formal palliative care services among patients with chronic obstructive pulmonary disease increased by 1% per year, going from 5.3% in 2004 to 14.3% in 2014.
Repeated assessments improved the patients' ability to assess their own situation and the case workers' understanding of the patients' situations.
An observational study was conducted in order to determine the accuracy and quality of readings provided by home blood pressure monitoring systems.
Researchers from the University of Rochester identified improvement in pulmonary function in symptomatic adult patients with asthma treated with once-daily tiotropium.
The budesonide extended-release formulation was found to be safe and well tolerated for the remission of ulcerative colitis, regardless of age or gender.
A 2-week course of treatment with rifaximin for diarrhea-predominant irritable bowel syndrome was found to improve abdominal pain symptoms.
The percentage of NPs who order the mt-sDNA test for colorectal cancer screening has increased significantly since the test became available in 2014.
Postmenopausal women have little awareness of osteoporotic fracture risk and poor understanding that a fragility fracture may be indicative of osteoporosis and that it increases future fracture risk.
The final analysis set comprised biologic-naïve individuals — individuals who had filled an initial prescription for etanercept, infliximab, adalimumab, or ustekinumab after 2 years without using any biologic agent during the study period.
This marks the first approved drug that contains an active ingredient derived from marijuana as well as the first treatment approved for patients with Dravet syndrome.
The Company indicated that they will work towards an New Drug Application submission for the treatment in the second half of 2018.
These findings are in line with previous research, which suggested that abuse and neglect in childhood have different effects on the brain.
The CDC has identified an increasing number of Shigella isolates that test within the susceptible range for the fluoroquinolone antibiotic ciprofloxacin.
ACX-362E is a targeted, narrow spectrum oral antibiotic that blocks the DNA replication process through inhibition of polymerase III, which has been shown to be bactericidal.
As antipsychotic medications are vital to the effective management of severe psychiatric disorders, investigators sought to examine reasons for medication nonadherence in patients with schizophrenia, bipolar disorders, and other psychotic disorders.
In patients with and without dementia, amyloid-positive and negative results were significantly linked to diagnoses and treatment changes.
NAPNAP has called on the US Department of Homeland Security, in collaboration with the Justice Department, to protect the health and wellness of immigrant children by voicing their opposition to the border separation of children and parents.
Double lung transplantation appears to offer superior survival outcomes to single lung transplantation in patients with interstitial pulmonary fibrosis who are younger than 70 years.
Schizophrenia, Major Depressive Disorder, Bipolar Disorder Linked With Abnormal Functional Connectivity
Local functional connectivity may serve as neuroimaging marker to investigate the human brain connectome.
Although heads of state and governments have pledged to reduce premature mortality from noncommunicable diseases by one-third by 2030, many countries are not on track to achieve this goal.
The risk of intussusception within 1 to 7 days and 8 to 21 days after rotavirus vaccination was assessed in infants age 28 to 245 days.
Patients with chronic hepatitis B have a lower risk of hepatic events if they achieve normal on-treatment ALT in the first 12 months of NA treatment.
Elderly patients aged 80 years and older have an increased risk of developing cardiovascular disease (CVD) with worse hearing as well as hearing deterioration.
Researchers assessed the effect of testosterone, estradiol, dehydroepiandrosterone, and sex hormone-binding globulin levels on coronary heart disease, heart failure, and cardiovascular disease in postmenopausal women.
With the increasing number of patients presenting to surgery with opioid tolerance, clinicians should be familiar with their specific analgesic needs.
Sodium chloride content of intravenous fluids does not affect neurologic events in children with diabetic ketoacidosis.
Nonsteroidal anti-inflammatory drug use mediated a substantial amount of cardiovascular disease risk in osteoarthritis.
The American Academy of Pediatrics releases a new clinical report on the diagnosis and treatment of clinically significant gastroesophageal reflux.
In patients receiving opioid substitution treatment for opioid use disorder (mainly involving heroin), those exhibiting a rapid decline in heroin use were found to be more likely to have successful treatment outcomes.
The genetic risk score primarily modified the risk for and onset of dementia and AD among homozygous carriers for APOE ε4.
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Clinical Advisor Articles
- High Rates of Salmonella Contamination Identified in Kratom
- Chemotherapy With Bevacizumab May Improve Some Ovarian Cancer Outcomes, Worsen Others
- Lack of Vaccination in High-Exempt Areas Linked to Medical Distrust
- Emergency Physicians Offer Recommendations for Identifying and Managing Opioid Use Disorder
- Link Between Bullous Pemphigoid and Dipeptidyl Peptidase-4 Inhibitors
- Nursing Faculty Ill Prepared to Educate Students on Transgender Patient Care
- Lofexidine a Non-Narcotic Option for Opioid Withdrawal Symptoms
- Chagas Disease in the United States: A Growing Public Health Concern
- Pain Societies Issue Guidelines on Use of Ketamine for the Management of Acute Pain
- Discharge Tools, Follow-Up Calls Reduce Readmission for Congestive Heart Failure
- Interrelationship Between Celiac Disease, Self-Reported Wheat Sensitivity, and Functional GI Disorders
- Fidaxomicin Effective for Long-Term Cure of Clostridium difficile
- Cardiac Pathology in SUDEP Compared With Sudden Arrhythmic or Traumatic Deaths
- Subclinical Hypothyroidism: Controversies in Testing and Treatment
- Skin Cancer Education May Improve Sun Protection Practices Among Organ Transplant Recipients