Web Exclusives

FDA approves new drug for postmenopausal pain during sex

FDA approves new drug for postmenopausal pain during sex

Intrarosa provides an additional treatment option for women with dyspareunia caused by vulvar and vaginal atrophy.

Depression rate high in patients with mild cognitive impairment

Depression rate high in patients with mild cognitive impairment

About one-third of patients with MCI are also diagnosed with depression.

Testosterone treatment may increase risk of venous thromboembolism

Testosterone treatment may increase risk of venous thromboembolism

Researchers sought to determine the risk of venous thromboembolism associated with use of testosterone treatment.

New clinical trial underway to study efficacy of HIV vaccine

New clinical trial underway to study efficacy of HIV vaccine

The study will be the largest HIV vaccine clinical trial to take place in South Africa.

Smartphone questionnaire effective for monitoring mood instability

Smartphone questionnaire effective for monitoring mood instability

The Mood Zoom questionnaire rates anxiety, elation, sadness, anger, irritability, and energy on a 7-point scale.

AAP recommendations for behavioral and emotional problems in young children

AAP recommendations for behavioral and emotional problems in young children

Most young children with an emotional, behavioral, or relationship problem receive no interventions for their disorder.

Rates and causes of emergency department visits for adverse drug events

Rates and causes of emergency department visits for adverse drug events

Data regarding adverse drug events in the United States could help to focus medication safety initiatives in outpatient settings.

Elevated blood pressure trends have shifted worldwide

Elevated blood pressure trends have shifted worldwide

The prevalence of elevated blood pressure rates shifted from high-income to low- and middle-income countries.

Is vasectomy linked to risk of prostate cancer?

Is vasectomy linked to risk of prostate cancer?

Vasectomy can continue to be a safe method of contraception in men.

Alternative strategies effective for diagnosing gout

Alternative strategies effective for diagnosing gout

Multidimensional algorithms may help clinicians make a provisional diagnosis of gout.

Managing peripheral artery disease: an updated guideline

Managing peripheral artery disease: an updated guideline

The AHA/ACC guideline updates the 2005 recommendations on PAD management.

Calculator predicts success of live birth after in vitro fertilization

Calculator predicts success of live birth after in vitro fertilization

The findings may help couples plan infertility treatments more effectively.

Functional outcomes in septic arthritis after ultrasonography

Functional outcomes in septic arthritis after ultrasonography

Patients with septic arthritis with poor functional outcome who underwent ultrasonography showed decreased synovial thickness at 3 months.

Antenatal antiretroviral therapy reduces early HIV transmission

Antenatal antiretroviral therapy reduces early HIV transmission

Antenatal ART reduces rates of early HIV transmission but may increase risk of adverse maternal and neonatal outcomes.

Smoking more harmful for HIV patients than the virus

Smoking more harmful for HIV patients than the virus

Men and women who quit smoking after entering HIV care at age 40 years gained 5.7 years and 4.6 years of life expectancy, respectively, compared with those who continued to smoke.

Benefits of structured rehabilitation program for hand osteoarthritis

Benefits of structured rehabilitation program for hand osteoarthritis

Patients benefit from non-pharmacological treatment in a structured arthritis rehabilitation program.

Statin and PCSK9 inhibitor combination more effective at lowering cholesterol

Statin and PCSK9 inhibitor combination more effective at lowering cholesterol

PCSK9 inhibition produces incremental benefits on coronary disease progression in patients treated with statins.

USPSTF releases final statin recommendations for CVD prevention

USPSTF releases final statin recommendations for CVD prevention

The task force finalizes recommendations for statin therapy among adults between 40 and 75 years of age.

Consultation rates for symptoms related to inflammatory arthritis increase prior to diagnosis

Consultation rates for symptoms related to inflammatory arthritis increase prior to diagnosis

Consultations for musculoskeletal symptoms and infections increase prior to an inflammatory arthritis diagnosis.

2016 NP Week focuses on increasing access to healthcare

2016 NP Week focuses on increasing access to healthcare

The AANP celebrates National Nurse Practitioner Week from November 13-19, 2016.

Improvement needed in managing COPD in women

Improvement needed in managing COPD in women

The prevalence of COPD globally is increasing more rapidly in women than in men.

High cognitive reserve results in better neurocognitive performance in bipolar disorder

High cognitive reserve results in better neurocognitive performance in bipolar disorder

Cognitive reserve in bipolar patients gives a possible explanation for the differences seen among patients in their ability to perform in neurocognitive tests.

End of daylight saving time may increase depression risk

End of daylight saving time may increase depression risk

The transition to standard time is likely to be associated with a negative psychological effect.

COPD Assessment Test indicates mortality risk in interstitial lung disease

COPD Assessment Test indicates mortality risk in interstitial lung disease

Researchers conducted a study to verify the CAT as a predictor of outcome among patients with interstitial lung disease.

Effects of maternal age on the decline of preterm birth

Effects of maternal age on the decline of preterm birth

The CDC examined the effects of maternal age on the decline of preterm birth in the United States between 2007 and 2014.

USPSTF releases draft recommendation for obesity screening in children and adolescents

USPSTF releases draft recommendation for obesity screening in children and adolescents

The USPSTF recommends that children and adolescents older than age 6 years should be screened for obesity.

Edible seeds becoming major food allergens

Edible seeds becoming major food allergens

The inclusion of seeds in food and food products may be a contributing factor in the increase of seed allergies.

Indoor environmental control strategies to manage asthma in children

Indoor environmental control strategies to manage asthma in children

Strategies include source removal, source control, and asthma education.

More than 1 million people treated with new hepatitis C drugs

More than 1 million people treated with new hepatitis C drugs

The cost of the new hepatitis C drugs in low- and certain middle-income countries is rapidly declining, according to a WHO study.

Excessive energy drink consumption leads to acute hepatitis case

Excessive energy drink consumption leads to acute hepatitis case

A 50-year-old man presents to the emergency department with abdominal pain, nausea, jaundice, and dark urine.

Barriers remain in patients' acceptance of naloxone use in primary care

Barriers remain in patients' acceptance of naloxone use in primary care

Patients would like more thorough conversations with their primary care physician over the use of naloxone.

Comparing treatments for pediatric migraines

Comparing treatments for pediatric migraines

No significant differences were observed among treatments for pediatric migraines.

ADA issues new diabetes guidelines for physical activity and exercise

ADA issues new diabetes guidelines for physical activity and exercise

The ADA releases its first independent recommendations on physical activity and exercise for all patients with diabetes.

Cancer-related deaths attributed to smoking vary across states

Cancer-related deaths attributed to smoking vary across states

Cancer deaths attributed to cigarette smoking are common among the Southern states.

HIV's newly traced origins in US discredit Patient Zero theory

HIV's newly traced origins in US discredit Patient Zero theory

The study debunks the theory that Patient Zero was responsible for the AIDS epidemic in North America.

AAP updates recommendations for SIDS and safe infant sleeping environment

AAP updates recommendations for SIDS and safe infant sleeping environment

A safe sleep environment can prevent suffocation and strangulation, two major causes of sudden infant death.

Increasing recruitment to meet demand for HIV care providers

Increasing recruitment to meet demand for HIV care providers

Speakers at IDWeek 2016 addressed the demand for additional HIV care providers.

DMPA contraceptives linked to increased HIV risk

DMPA contraceptives linked to increased HIV risk

Recent data suggest that use of depot medroxyprogesterone acetate may increase women's HIV acquisition risk.

Long-term oxygen therapy not beneficial for COPD patients with moderate desaturation

Long-term oxygen therapy not beneficial for COPD patients with moderate desaturation

Long-term supplemental oxygen has no benefit in patients with stable COPD and resting or exercise-induced moderate desaturation.

Caffeine does not induce arrhythmias in patients with heart disease

Caffeine does not induce arrhythmias in patients with heart disease

Caffeine consumption in patients with systolic heart failure does not induce arrhythmias both at rest and during physical exercise.

COPD and idiopathic pulmonary fibrosis may have common genetic network

COPD and idiopathic pulmonary fibrosis may have common genetic network

Researchers used integrated genomics to identify convergent transcriptomic pathways in emphysema and IPF.

USPSTF recommends primary care breastfeeding intervention support

USPSTF recommends primary care breastfeeding intervention support

The USPSTF reviewed evidence on the benefits and harms of breastfeeding support interventions.

Omalizumab effective for asthma and overlapping COPD

Omalizumab effective for asthma and overlapping COPD

Omalizumab is useful in the management of severe asthma with overlapping COPD.

Pulmonary embolism common in patients hospitalized for syncope

Pulmonary embolism common in patients hospitalized for syncope

One in 6 patients hospitalized for a first episode of syncope experiences a pulmonary embolism.

Depression may worsen outcomes in patients with chronic stable angina

Depression may worsen outcomes in patients with chronic stable angina

Depression can occur in approximately 1 in 5 patients who have chronic stable angina.

DEA reverses plan to ban potential opioid alternative kratom

DEA reverses plan to ban potential opioid alternative kratom

After public opposition, the DEA has withdrawn its plan to classify the kratom plant as a schedule 1 substance.

Complementary health approaches frequently used for musculoskeletal pain disorders

Complementary health approaches frequently used for musculoskeletal pain disorders

Data from the CDC's National Health Statistics Reports show that more than half of adults in the United States have a musculoskeletal pain disorder.

CDC approves HPV vaccine in 2 doses for preteens

CDC approves HPV vaccine in 2 doses for preteens

Children younger than 15 may be given 2 HPV vaccine doses instead of 3, and the shots should be spaced at least 6 months apart.

New clinical practice guidelines for red blood cell transfusion

New clinical practice guidelines for red blood cell transfusion

The AABB evaluated studies that examined hemoglobin thresholds for red blood cell transfusion and red blood cell storage duration.

Quality of outpatient care not consistently improving

Quality of outpatient care not consistently improving

The quality of clinical outpatient care has not consistently improved throughout the past decade.

Controversy over CDC guidelines on prescribing opioids for chronic pain

Controversy over CDC guidelines on prescribing opioids for chronic pain

Guidelines created in response to the opioid epidemic in the United States have caused controversy in the medical community.

Cervical cancer screening intervals effective beyond 5 years

Cervical cancer screening intervals effective beyond 5 years

Data from the POBASCAM trial support the extension of screening intervals for cervical cancer beyond 5 years.

NSAID use linked to increased risk of heart failure hospitalization

NSAID use linked to increased risk of heart failure hospitalization

Some individual NSAIDs may be linked to increased risk of hospital admission for heart failure.

FDA requires black box warning on HCV drugs regarding potential HBV reactivation

FDA requires black box warning on HCV drugs regarding potential HBV reactivation

The FDA issues a warning about the risk of hepatitis B virus reactivation among patients taking direct-acting antivirals to treat hepatitis C infections.

Zika virus in amniotic fluid may help predict prenatal diagnosis

Zika virus in amniotic fluid may help predict prenatal diagnosis

Researchers examined prenatal evolution and perinatal outcomes in neonates with developmental abnormalities associated with Zika virus infections.

Treating alcohol use disorders in patients with alcoholic liver disease

Treating alcohol use disorders in patients with alcoholic liver disease

Total alcohol abstinence is the cornerstone of treatment for patients with alcohol use disorders and alcoholic liver disease.

Reducing the duration of hepatitis C therapy may be effective

Reducing the duration of hepatitis C therapy may be effective

Shortening the duration of HCV therapy from 12 weeks to 3 weeks could substantially reduce the cost of treatment.

Nighttime hot flashes may be linked to mild depression

Nighttime hot flashes may be linked to mild depression

Women who experience more nighttime hot flashes are more likely to experience worsening mood during menopause.

Hormonal contraception use associated with depression

Hormonal contraception use associated with depression

Women who use hormonal contraception have an increased risk for first use of an antidepressant and first diagnosis of depression.

NCCPA survey results show PA certification continues to increase

NCCPA survey results show PA certification continues to increase

The biggest challenges for recently certified PAs are the lack of clinical PA opportunities for recent graduates and the lack of clinical PA opportunities in a geographic area.

Identifying patients at risk of life-threatening allergic reactions to food

Identifying patients at risk of life-threatening allergic reactions to food

Researchers examine factors that could help clinicians identify patients with the highest risk of fatal anaphylaxis.

National PA Week 2016 honors the profession's growing influence

National PA Week 2016 honors the profession's growing influence

The AAPA celebrates National PA Week from October 6-12, 2016.

Statin-based therapy less effective in advanced chronic kidney disease

Statin-based therapy less effective in advanced chronic kidney disease

Statin-based therapy had a smaller effect in reducing major vascular events in patients with advanced chronic kidney disease.

Stepwise diabetes prevention effective in patients with prediabetes

Stepwise diabetes prevention effective in patients with prediabetes

Individuals with prediabetes may reduce their risk of diabetes with stepwise diabetes prevention.

Lack of epidemiologic indicators increases risk of missed HIV diagnosis

Lack of epidemiologic indicators increases risk of missed HIV diagnosis

The results of a multicenter, cross-sectional study showed that 37% of patients could have been diagnosed with HIV at an earlier stage.

Nonmedical use of prescription opioids in adolescence leads to substance use disorder symptoms in adulthood

Nonmedical use of prescription opioids in adolescence leads to substance use disorder symptoms in adulthood

Using medical or nonmedical prescribed opioids in adolescence may lead to alcohol, drug, and mental health disorders in adulthood.

Nausea and vomiting may reduce the risk of pregnancy loss

Nausea and vomiting may reduce the risk of pregnancy loss

Nausea and vomiting were common in early pregnancy and are associated with a lower risk of pregnancy loss.

Massage therapy may be beneficial for surgical pain

Massage therapy may be beneficial for surgical pain

Massage therapy appears to be efficacious for reducing pain and anxiety in patients who are about to undergo or are recovering from surgical procedures.

Comparing first-line antiretroviral therapies for HIV

Comparing first-line antiretroviral therapies for HIV

The efficacy and safety of ART have greatly improved with the newer drug classes of antiretrovirals.

Screening for preeclampsia recommended by USPSTF

Screening for preeclampsia recommended by USPSTF

The USPSTF releases a draft recommendation statement regarding preeclampsia screening in pregnant women.

Timolol effective treatment for infantile hemangiomas

Timolol effective treatment for infantile hemangiomas

Topical timolol maleate may be safe and effective for infantile hemangiomas, amid concerns about the potential overuse of propranolol.

Binge-eating disorder: a review of effective treatment options

Binge-eating disorder: a review of effective treatment options

Cognitive behavioral therapy, lisdexamfetamine, second-generation antidepressants, and topiramate reduced binge eating.

Cohort effect shows earlier and stronger effects of bipolar disorder

Cohort effect shows earlier and stronger effects of bipolar disorder

Researchers observe a cohort effect for earlier age at onset of bipolar disorder. Bipolar disorder is also more common in patients with a family history of unipolar depression and bipolar disorder.

Immediate antiretroviral therapy may reduce infection-related cancer in HIV

Immediate antiretroviral therapy may reduce infection-related cancer in HIV

Patients with HIV infection with immediate access to antiretroviral therapy may have a reduced risk of infection-related cancer.

Bipolar disorder treatment more effective in earlier stages

Bipolar disorder treatment more effective in earlier stages

Treatment initiated in the early stages of bipolar disorder is more effective than treatment in later stages.

Use of stronger antibiotics increases in US hospitals

Use of stronger antibiotics increases in US hospitals

Although the overall use of antibiotics in US hospitals is unchanged, use of broad spectrum agents has increased significantly.

The FDA approves first drug for Duchenne muscular dystrophy

The FDA approves first drug for Duchenne muscular dystrophy

Data showed an increase in dystrophin production that could predict clinical benefit among patients with DMD.

Codeine use unsafe in children, AAP issues stronger warning

Codeine use unsafe in children, AAP issues stronger warning

Additional clinical research is required to understand the risk and benefits of opioid and nonopioid alternatives for acute pain.

Multibiomarker disease activity predicts relapse in rheumatoid arthritis patients

Multibiomarker disease activity predicts relapse in rheumatoid arthritis patients

Multibiomarker disease activity improved relapse prediction in RA patients who are in remission.

Patient personality may affect treatment adherence in rheumatoid arthritis

Patient personality may affect treatment adherence in rheumatoid arthritis

Early and aggressive management of RA is urged by investigators.

Age as a determining factor in TNFi discontinuation in rheumatoid arthritis

Age as a determining factor in TNFi discontinuation in rheumatoid arthritis

It is critical to identify disease-modifying antirheumatic drugs for elderly patients with rheumatoid arthritis.

Bariatric surgery linked to an increased risk of preterm birth

Bariatric surgery linked to an increased risk of preterm birth

Pregnant women with a history of bariatric surgery may have an increased risk of preterm birth.

Menopausal transition linked to rapid increase in metabolic syndrome severity

Menopausal transition linked to rapid increase in metabolic syndrome severity

The American Heart Association found that during menopausal transition, women have a rapid increase in metabolic syndrome severity.

Acute exacerbations may accelerate lung function decline in smokers with COPD

Acute exacerbations may accelerate lung function decline in smokers with COPD

Exacerbations were associated with accelerated lung function loss in patients with established COPD.

MRI safe in early pregnancy, gadolinium use linked to adverse outcomes

MRI safe in early pregnancy, gadolinium use linked to adverse outcomes

Gadolinium-enhanced MRI is associated with an increased risk of stillbirth or neonatal death, as well as rheumatologic, inflammatory, or infiltrative skin conditions.

Screening for latent tuberculosis infection: USPSTF finalizes recommendation

Screening for latent tuberculosis infection: USPSTF finalizes recommendation

The USPSTF task force reviewed evidence regarding screening for LTBI in asymptomatic adults.

Pancreatic cancer is most lethal pancreatic disorder worldwide

Pancreatic cancer is most lethal pancreatic disorder worldwide

The mortality rate from pancreatic cancer is significantly higher in the American region than in the European and Western Pacific regions.

Hepatitis C virus core antigen testing is a highly accurate diagnostic tool

Hepatitis C virus core antigen testing is a highly accurate diagnostic tool

HCVcAg assays with signal amplification have the potential to replace NAT in settings with high HCV prevalence.

Addressing parental vaccine concerns: AAP provides guidance for clinicians

Addressing parental vaccine concerns: AAP provides guidance for clinicians

The AAP has released a report to help clinicians address the concerns of parents who are hesitant about their children's vaccination.

Obeticholic acid may be effective for primary biliary cholangitis

Obeticholic acid may be effective for primary biliary cholangitis

In patients with primary biliary cholangitis obeticholic acid was associated with significant decreases in alkaline phosphatase and total bilirubin levels.

Folic acid-fortified foods linked to lower risk of congenital heart defects

Folic acid-fortified foods linked to lower risk of congenital heart defects

Foods fortified with folic acid are associated with a decrease in infants being born with congenital heart defects.

Using neuroimaging in chronic pain management

Using neuroimaging in chronic pain management

Developments in functional, structural, and neurochemical imaging could help predict individuals with acute pain who are likely to progress to chronic pain.

Oxycodone/naloxone may be beneficial for managing pain after total knee replacement

Oxycodone/naloxone may be beneficial for managing pain after total knee replacement

Oxycodone/naloxone may provide effective analgesia and improve patients' ability to participate in physiotherapy.

Food allergies in children linked to high risk of asthma, rhinitis

Food allergies in children linked to high risk of asthma, rhinitis

Researchers measured rates of childhood allergic conditions with data from healthcare provider-based diagnoses.

Group prenatal care vs traditional prenatal care

Group prenatal care vs traditional prenatal care

Group prenatal care may lower the risk of preterm birth in African American women.

CPAP does not prevent cardiovascular events in obstructive sleep apnea

CPAP does not prevent cardiovascular events in obstructive sleep apnea

Patients with obstructive sleep apnea did not have reduced cardiovascular events after CPAP in addition to usual care.

Early intensification of diabetes therapy after metformin failure is beneficial

Early intensification of diabetes therapy after metformin failure is beneficial

Intensification of therapy within 6 months of metformin monotherapy failure resulted in rapid attainment of A1c goals.

Study cites factors behind the high cost of prescription drugs in the United States

Study cites factors behind the high cost of prescription drugs in the United States

A peer-review analysis identified the source of increasing drug prices in the United States.

Team-based care may be more effective than traditional practice management in primary care

Team-based care may be more effective than traditional practice management in primary care

Researchers compared quality of care, acute care use, and program investment costs of team-based care and traditional practices.

Many parents place their infants in unsafe sleep environments

Many parents place their infants in unsafe sleep environments

Many parents do not place their infants in a supine position, or place them on nonrecommended surfaces with loose items.

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