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Third Trimester Immunization With Tdap Vaccine Optimal for Pertussis Toxin Antibody Concentrations in Newborns

Third Trimester Immunization With Tdap Vaccine Optimal for Pertussis Toxin Antibody Concentrations in Newborns

Immunization with Tdap vaccine during the third trimester of pregnancy resulted in higher concentrations of pertussis toxin antibodies in newborns.

Nutrition Tips for Physicians: Staying Healthy During Busy Days

Nutrition Tips for Physicians: Staying Healthy During Busy Days

Between the double shifts and stressful days, keeping energy up and eating right can seem like an insurmountable challenge.

AGA: New Opioid-Induced Constipation Management Guidelines Available

AGA: New Opioid-Induced Constipation Management Guidelines Available

The recommendations have been published in the AGA's official journal, Gastroenterology.

One-Time, Universal Screening for Hepatitis C Is Cost-Effective

One-Time, Universal Screening for Hepatitis C Is Cost-Effective

Universal 1-time screening for chronic HCV infection is cost-effective compared with no screening or with birth cohort-based screening alone.

Updated HCV Treatment Guidelines for 2018 Published by AASLD-IDSA

Updated HCV Treatment Guidelines for 2018 Published by AASLD-IDSA

The American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) released updates guidelines for treating hepatitis C infection.

Retirement Associated With Increased Risk for Depressive Symptoms

Retirement Associated With Increased Risk for Depressive Symptoms

Employment status displayed a lagged effect on depression, with retirement preceding higher levels of depression 2 years after initial retirement status report.

Rifle Type Affects Number of People Wounded, Killed in Active Shooter Incidents

Rifle Type Affects Number of People Wounded, Killed in Active Shooter Incidents

Researchers suggested that more data is required to create a centralized database that can be used to inform the debate on an assault weapons ban.

Patient Perceptions of Clinical Notes at Issue Among Mental Health Providers

Patient Perceptions of Clinical Notes at Issue Among Mental Health Providers

More primary care practices have been making medical records, including clinical notes, available to patients via secure electronic portals.

Talzenna Approved for Germline BRCA-Mutated, HER2-Negative Breast Cancer

Talzenna Approved for Germline BRCA-Mutated, HER2-Negative Breast Cancer

Talzenna, a poly (ADP-ribose) polymerase (PARP) inhibitor, was evaluated in EMBRACA, an open-label trial that randomized patients with gBRCAm HER2-negative locally advanced or metastatic breast cancer (N=431) to receive talazoparib 1mg or physician's choice of chemotherapy (capecitabine, eribulin, gemcitabine, or vinorelbine).

Liletta Now Approved for Pregnancy Prevention for Up to 5 Years

Liletta Now Approved for Pregnancy Prevention for Up to 5 Years

The expanded approval was supposed by safety and efficacy data from the Phase 3 ACCESS IUS trial (N=1751) in women receiving Liletta. In the trial, Liletta demonstrated >99% efficacy in preventing pregnancy for up to 5 years in a broad patient population.

The Misuse of Antibiotics in Acute Pancreatitis Appears Widespread

The Misuse of Antibiotics in Acute Pancreatitis Appears Widespread

The inappropriate use of antibiotics as prophylaxis and treatment in acute pancreatitis is common, highlighting the efforts required for antibiotic stewardship.

Exercise After Overnight Fasting Stabilizes Glucose Levels in Type 1 Diabetes

Exercise After Overnight Fasting Stabilizes Glucose Levels in Type 1 Diabetes

The effect of high-intensity interval training with a bout of moderate-intensity continuous training on glucose levels was examined in T1D.

Vegan Diet Associated With Weight Loss and Reduced Insulin Resistance

Vegan Diet Associated With Weight Loss and Reduced Insulin Resistance

Investigators examine the effect of a low-fat, plant-based diet on insulin resistance and body composition.

β-Blockers in Early Pregnancy Not Linked to Significant Risk for Overall, Cardiac Malformations

β-Blockers in Early Pregnancy Not Linked to Significant Risk for Overall, Cardiac Malformations

The use of β-blockers in the first trimester of pregnancy may not greatly increase the risk for major congenital malformations in offspring.

Seven-Item Pain Intensity Measure Reliable in Individuals With Dementia

Seven-Item Pain Intensity Measure Reliable in Individuals With Dementia

A 7-item pain intensity measure for persons with dementia has shown initial validity and reliability.

Pneumococcal H Influenzae Protein D Conjugate Vaccine Effective in Children

Pneumococcal H Influenzae Protein D Conjugate Vaccine Effective in Children

The burden of childhood and infant pneumonia can be effectively reduced through the use of the pneumococcal Haemophilus influenzae protein D conjugate vaccine.

Microscopic Colitis Risk Not Linked to Dietary Gluten in Women Without Celiac Disease

Microscopic Colitis Risk Not Linked to Dietary Gluten in Women Without Celiac Disease

The consumption of dietary gluten was not associated with microscopic colitis risk in patients without celiac disease.

Higher Levels of Anti-CA15.3 and Anti-CA125 Linked to Increased Risk for Mucinous Epithelial Ovarian Cancer

Higher Levels of Anti-CA15.3 and Anti-CA125 Linked to Increased Risk for Mucinous Epithelial Ovarian Cancer

Researchers used the EPIC Cohort to identify whether anti-CA125 and anti-CA15.3 antibodies alone or in combination with antigens may determine epithelial ovarian cancer risk.

Better Efforts Needed for Cancer Patients With Pessimistic Illness Perceptions

Better Efforts Needed for Cancer Patients With Pessimistic Illness Perceptions

Among cancer survivors, illness perception may affect patient health-related quality of life and mortality.

Ovarian Cancer Risk Reduced With Regular, Low-Dose Aspirin

Ovarian Cancer Risk Reduced With Regular, Low-Dose Aspirin

Although ovarian cancer risk may be reduced with regular use of low-dose aspirin, the use of nonaspirin analgesics may increase the risk of ovarian cancer among long-term, high-quantity users.

AAPA and NCCPA Partner to Campaign for Physician Assistant Recognition

AAPA and NCCPA Partner to Campaign for Physician Assistant Recognition

AAPA and NCCPA partner in a national advertising campaign to raise awareness of the PA profession.

Change in Dietary Patterns Over 5 Years in Early Multiple Sclerosis

Change in Dietary Patterns Over 5 Years in Early Multiple Sclerosis

Researchers analyze the dietary habits of 260 patients in the early stages of multiple sclerosis from baseline to 5 years after initial onset of symptoms.

Empagliflozin Impact on Life Expectancy Examined in T2DM Patients With CVD

Empagliflozin Impact on Life Expectancy Examined in T2DM Patients With CVD

For this analysis, the authors used follow-up data from all 7020 patients included in the EMPA-REG OUTCOME trial to estimate the effect of empagliflozin on all-cause mortality vs placebo over the duration of a patient's lifetime.

Rituximab Linked to HBV Reactivation in Patients With Prior Functional Cure

Rituximab Linked to HBV Reactivation in Patients With Prior Functional Cure

The study authors searched MEDLINE from inception through July 2018 to obtain relevant cohort studies and randomized trials assessing HBVr incidence secondary to pharmaceutical agents.

Ustekinumab Induces Clinical Remission After One Dose in Ulcerative Colitis Study

Ustekinumab Induces Clinical Remission After One Dose in Ulcerative Colitis Study

Study authors at the American College of Gastroenterology (ACG) Scientific Meeting 2018 presented late-breaking data from the induction phase of the Phase 3 UNIFI study.

Improvement in Guidelines for Monitoring Patients Receiving Lithium Essential

Improvement in Guidelines for Monitoring Patients Receiving Lithium Essential

The quality of patient monitoring may improve if the clinical practice guidelines are improved, as many healthcare professionals use the guidelines in their monitoring of patients taking lithium.

Hospitals Using Get With the Guidelines-Stroke Program Offer Better Quality Care in Ischemic Stroke

Hospitals Using Get With the Guidelines-Stroke Program Offer Better Quality Care in Ischemic Stroke

The Get With the Guidelines-Stroke program includes measures such as neurologist assessment, rehabilitation evaluation, and education on stroke risk factors.

Flea-Borne Typhus Outbreak in Los Angeles County

Flea-Borne Typhus Outbreak in Los Angeles County

An outbreak of flea-borne typhus in Los Angeles County has so far resulted in 57 cases, including 20 in Pasadena and 9 in downtown Los Angeles.

Novel Blood Test for Irritable Bowel Syndrome Now Available

Novel Blood Test for Irritable Bowel Syndrome Now Available

The test works by measuring levels of anti-cytolethal distending toxin B (CdtB) and anti-vinculin, 2 biomarkers of post-infectious IBS-D and IBS-M.

Fycompa Approved for Younger Epilepsy Patients With Partial-Onset Seizures

Fycompa Approved for Younger Epilepsy Patients With Partial-Onset Seizures

Safety data for Fycompa was consistent with the safety profile in adult populations without the need for weight-based dosing.

New AAN Guidelines for the Management of Disorders of Consciousness

New AAN Guidelines for the Management of Disorders of Consciousness

The new guidelines place a substantial emphasis on the importance of introducing high-quality rehabilitation early in these patients.

Gardasil 9 Approved for Use in Women and Men 27 Through 45 Years Old

Gardasil 9 Approved for Use in Women and Men 27 Through 45 Years Old

The approval of the expanded age range was based on data from a clinical trial which evaluated the efficacy of Gardasil (quadrivalent human papillomavirus recombinant vaccine) in 3253 women 27-45 years of age with a median duration of follow-up of 3.5 years post-dose 3.

Need for Adequate Screening for Infants With HCV Infected Mothers During Pregnancy

Need for Adequate Screening for Infants With HCV Infected Mothers During Pregnancy

One of the goals of the US Department of Health and Human Services National Viral Hepatitis Action Plan is to eliminate mother-to-infant transmission of HCV infection.

FDA Amends Food Additive Regulations to No Longer Allow Use of 7 Substances

FDA Amends Food Additive Regulations to No Longer Allow Use of 7 Substances

The petition was submitted by a number of non-profit organizations including the Center for Science in the Public Interest and the Breast Cancer Fund.

Sofosbuvir-Based Regimens Safe, Effective for Chronic Hepatitis C in the Community

Sofosbuvir-Based Regimens Safe, Effective for Chronic Hepatitis C in the Community

Investigators examined treatment response of sofosbuvir-based DAA in patients with chronic hepatitis C with compensated liver cirrhosis in a community care setting.

NDA Submitted for Valtoco Nasal Spray to Treat Acute Repetitive Seizures

NDA Submitted for Valtoco Nasal Spray to Treat Acute Repetitive Seizures

The Company states that the NDA is supported by robust clinical trial data, including patients studies where more than 1600 seizures were treated with Valtoco nasal spray.

Variations in Influenza Vaccination Coverage Among Healthcare Employees Reported

Variations in Influenza Vaccination Coverage Among Healthcare Employees Reported

Wide variations in influenza vaccine coverage have been noted across healthcare personnel based on occupation and worksite.

Folic Acid Supplementation May Protect Against Language Delay in AED-Exposed Children

Folic Acid Supplementation May Protect Against Language Delay in AED-Exposed Children

The odds of language delay were lower at 18 months and 36 months in children exposed to AEDs in utero whose mothers took folic acid.

Late-Onset Epilepsy Linked to APOE ε4, Smoking, Diabetes

Late-Onset Epilepsy Linked to APOE ε4, Smoking, Diabetes

The risk for late-onset epilepsy was lower in patients with higher physical activity levels and moderate alcohol intake.

Outcomes After Seizure Recurrence Upon AED Withdrawal Following Temporal Lobectomy

Outcomes After Seizure Recurrence Upon AED Withdrawal Following Temporal Lobectomy

Recurrence of seizures was reported in 28.2% of patients who attempted withdrawal.

Weight Loss May Predict Cancer Diagnosis in Primary Care

Weight Loss May Predict Cancer Diagnosis in Primary Care

Weight loss may indicate a cancer diagnosis in patients presenting in primary care, specifically when weight loss correlates to another cancer-related clinical feature.

Glecaprevir/Pibrentasvir Is Safe, Efficacious for HCV/HIV-1 Coinfection

Glecaprevir/Pibrentasvir Is Safe, Efficacious for HCV/HIV-1 Coinfection

Analysis of 2 phase 3 clinical trials evaluating the safety/efficacy of glecaprevir/pibrentasvir in people with HCV coinfected with HIV-1 found an overall sustained virologic response of 98% at week 12 of treatment in those with or without cirrhosis.

Diabetes Common in Patients With Ischemic, Hemorrhagic Stroke

Diabetes Common in Patients With Ischemic, Hemorrhagic Stroke

Approximately 28% of stroke patients have diabetes, and the presence of diabetes can increase the risk for poor stroke outcome.

Active Choice Intervention Effective in Increasing Influenza Vaccination Rates at Primary Care Practices

Active Choice Intervention Effective in Increasing Influenza Vaccination Rates at Primary Care Practices

Influenza vaccination rates decline as the clinic day progresses.

Discrepancy Between Primary Care Screening for Alcohol Use and Screening for Depression

Discrepancy Between Primary Care Screening for Alcohol Use and Screening for Depression

Screening of adult patients with significant depressive symptoms is often inadequate in the primary care setting, especially among those with hazardous alcohol consumption.

Relationships Between Prescribing for UTI, E coli Bacteremia, Resistance

Relationships Between Prescribing for UTI, E coli Bacteremia, Resistance

New data suggest an association between general practitioners' prescribing habits for urinary tract infections and UTI-related E coli bacteremia incidence.

Fluoroquinolones May Aid in Reducing Mortality in Community-Acquired Pneumonia

Fluoroquinolones May Aid in Reducing Mortality in Community-Acquired Pneumonia

For patients with CAP, antibiotic regimens including a fluoroquinolone may reduce mortality risk by 1-2% compared to beta-lactams and cephalosporins alone.

Probiotic Use May Not Protect Against Clostridium Difficile Infection

Probiotic Use May Not Protect Against Clostridium Difficile Infection

In patients taking multiple antibiotics, proton pump inhibitors, or histamine receptor antagonists, the concurrent use of probiotics was associated with an increased incidence of Clostridium difficile infection

A Single Combination Tablet Suppresses HIV Load Through 48 Weeks

A Single Combination Tablet Suppresses HIV Load Through 48 Weeks

A combination single tablet once-a-day regimen of doravirine/lamivudine/tenofovir disoproxil fumarate demonstrated non-inferiority and no significant adverse events when compared with continuation of established antiretroviral therapy in adults infected with HIV-1.

Ketogenic Diet May Benefit Ovarian, Endometrial Cancer Patients

Ketogenic Diet May Benefit Ovarian, Endometrial Cancer Patients

Women with ovarian or endometrial cancer who adhere to a ketogenic diet may benefit from a selective loss of fat mass and a reduction in fasting serum insulin, while still retaining lean mass.

Delabeling Patients as Beta-Lactam Allergic Requires Record Updates

Delabeling Patients as Beta-Lactam Allergic Requires Record Updates

Changes in allergy records were suggested by the allergy service consult for 62% of the patients.

Additional Symjepi Dosage Strength Approved for Anaphylaxis Treatment

Additional Symjepi Dosage Strength Approved for Anaphylaxis Treatment

Both doses will be supplied in single-dose, prefilled syringes for manual injection.

Increasing Water Intake May Reduce Cystitis Recurrence

Increasing Water Intake May Reduce Cystitis Recurrence

For women at high risk for cystitis recurrence who drink low volumes of fluid daily, increasing water intake prevents recurrence.

Improved Documentation May Help Distinguish Beta-Lactam Allergy vs Intolerance

Improved Documentation May Help Distinguish Beta-Lactam Allergy vs Intolerance

A documented β -lactam allergy was found in more than one-third of patients receiving broad-spectrum antibiotics, however, only 10% of patients were found to be truly allergic.

High Susceptibility Antibiotics Reduce Readmission Rates for Urinary Tract Infections

High Susceptibility Antibiotics Reduce Readmission Rates for Urinary Tract Infections

The use of a moderate to low susceptibility antibiotic to treat a urinary tract infection [UTI] may result in a 1.74-fold increase in the odds of an emergency department readmission within 30 days for another UTI.

Monovalent Acellular Pertussis Vaccine Safe and Effective for Neonates With Mothers Unvaccinated for Tdap

Monovalent Acellular Pertussis Vaccine Safe and Effective for Neonates With Mothers Unvaccinated for Tdap

The monovalent acellular pertussis vaccine may be beneficial to neonates whose mothers did not receive Tdap vaccine during pregnancy.

Disorders in Pregnancy May Increase Risk for Hot Flashes During Menopause

Disorders in Pregnancy May Increase Risk for Hot Flashes During Menopause

Hypertensive disorders of pregnancy and gestational diabetes may increase the risk for hot flashes during menopause.

Sexual Harassment, Assault Affect Physical and Mental Health in Women

Sexual Harassment, Assault Affect Physical and Mental Health in Women

Women who were exposed to sexual harassment and/or assault were found to experience higher blood pressure, poorer sleep, and mood changed that can affect mental health.

Celecoxib Offers Pain Relief Comparable to Ketorolac After Robotic Hysterectomy

Celecoxib Offers Pain Relief Comparable to Ketorolac After Robotic Hysterectomy

Patients undergoing robotic hysterectomy were found to report comparable pain scores when receiving celecoxib perioperatively or ketorolac postoperatively.

Caring for Carriers: Do Direct-to-Consumer Genetic Test Results Have a Place in Primary Care?

Caring for Carriers: Do Direct-to-Consumer Genetic Test Results Have a Place in Primary Care?

A case and commentary published in the AMA Journal of Ethics discusses the ethics of primary care physician response to direct-to-consumer genetic testing results of concerned patients.

Light Therapy Offers Nonpharmacologic Treatment for Perimenopausal Depression

Light Therapy Offers Nonpharmacologic Treatment for Perimenopausal Depression

Light treatments successfully corrected abnormal timing of melatonin circadian rhythms in perimenopausal women with depression and improved mood and sleep within 2 weeks.

Switching IV to Oral Antibiotics Noninferior for Some Endocarditis Events

Switching IV to Oral Antibiotics Noninferior for Some Endocarditis Events

For certain patients with endocarditis on the left side of the heart under stable condition, switching from intravenous (IV) antibiotics to orally administered antibiotics is noninferior to staying on IV treatment.

Uncertain Future for Health Laws After Supreme Court Crisis Pregnancy Center Ruling

Uncertain Future for Health Laws After Supreme Court Crisis Pregnancy Center Ruling

The recent Supreme Court decision on crisis pregnancy centers is expected to complicate the future of some health laws.

Risk for Hypercalciuria With Recommended Dose of Vitamin D Supplement

Risk for Hypercalciuria With Recommended Dose of Vitamin D Supplement

The upper level of vitamin D recommended by the Endocrine Society can result in frequent hypercalciuria.

Barriers Found in PCP Knowledge of Surveillance of Hepatocellular Carcinoma

Barriers Found in PCP Knowledge of Surveillance of Hepatocellular Carcinoma

Barriers found among PCPs in surveillance of HCC indicate the need for clinical interventions, including provider education.

Effects of Parental Decision Aids on ED CT Rates Among Children at Risk for TBI

Effects of Parental Decision Aids on ED CT Rates Among Children at Risk for TBI

Emergency department computed tomography rates for children with minor head trauma were not affected by parent decision aid use.

Talazoparib Shows Antitumor Activity in Advanced Breast Cancer, Germline BRCA Mutation

Talazoparib Shows Antitumor Activity in Advanced Breast Cancer, Germline BRCA Mutation

Talazoparib, a poly(adenosine diphosphate-ribose) inhibitor, may significantly enhance progression-free survival in patients with advanced breast cancer and a germline BRCA1/2 mutation.

Gestational Diabetes Associated With Increased Risk for Postpartum Depression

Gestational Diabetes Associated With Increased Risk for Postpartum Depression

These findings suggest an increased risk for postpartum depressive symptoms in mothers with gestational diabetes, independent of depressive symptomatology during pregnancy.

Discrimination Concern in Adolescents Linked to Increased Substance Use

Discrimination Concern in Adolescents Linked to Increased Substance Use

Teens whose concern over societal discrimination grew between 2016 and 2017 increased their cigarette and marijuana use.

CPAP for OSA Does Not Improve Diabetic Macular Edema or Visual Acuity

CPAP for OSA Does Not Improve Diabetic Macular Edema or Visual Acuity

Continuous positive airway pressure for obstructive sleep apnea in patients with type 2 diabetes offered no improvement in visual acuity compared with usual care alone.

Reflux Band Now Available OTC for Reducing Laryngopharyngeal Reflux

Reflux Band Now Available OTC for Reducing Laryngopharyngeal Reflux

In one study, 86% of patients clinically diagnosed with esophagopharyngeal reflux reported significant reduction in symptoms after 2 weeks of use.

Aggression in Bipolar I Disorder and Psychosis Associated With Suicidal Ideation, Alcohol Abuse

Aggression in Bipolar I Disorder and Psychosis Associated With Suicidal Ideation, Alcohol Abuse

Management of alcohol abuse, suicidal ideation or behavior, and manic symptoms may reduce aggression among patients with bipolar disorder with psychotic features.

HPV Vaccination Decreases High-Grade Cervical Lesions in Women

HPV Vaccination Decreases High-Grade Cervical Lesions in Women

From 2008 to 2015, both cervical intraepithelial neoplasia grades 2, 3 and adenocarcinoma in situ rates and cervical cancer screening declined in women age 18 to 24 years.

Combination Immunosuppressive Therapy Beneficial for Type B Insulin Resistance

Combination Immunosuppressive Therapy Beneficial for Type B Insulin Resistance

A combined immunosuppressive regimen was found to be a highly effective and safe treatment for patients with type B insulin resistance.

Recreational Screen Time, Sleep Duration Linked to Cognitive Development in Children

Recreational Screen Time, Sleep Duration Linked to Cognitive Development in Children

More than 2 hours of recreational screen time was found to be associated with cognitive decline in children.

CDC Guideline for Opioid Prescribing May Have Effectively Reduced Opioid Prescribing Practices

CDC Guideline for Opioid Prescribing May Have Effectively Reduced Opioid Prescribing Practices

The Centers for Disease Control and Prevention's "Guideline for Prescribing Opioids for Chronic Pain" may have contributed to a further reduction in several opioid prescribing practices.

Pest Allergies in Urban Adolescents Exacerbate Poorly Controlled Asthma

Pest Allergies in Urban Adolescents Exacerbate Poorly Controlled Asthma

Cockroach and mouse allergies were most often associated with poorly controlled asthma and exacerbations in urban adolescents.

Allergy, But Not Asthma, Risk Increased in Children of East Asian Descent

Allergy, But Not Asthma, Risk Increased in Children of East Asian Descent

Children of East Asian-born parents had an increased risk for allergic rhinitis and aeroallergen sensitization compared with children of Caucasian ancestry.

The Ethics of Forced Cesareans: An Unthinkable Practice, Examined

The Ethics of Forced Cesareans: An Unthinkable Practice, Examined

"Moral norms" in the medical domain must be applied to pregnant women and their physicians.

Cesarean Delivery, Early Childhood Antibiotic Use Not Associated With Risk for ADHD

Cesarean Delivery, Early Childhood Antibiotic Use Not Associated With Risk for ADHD

This research rejects any association between increased risk for ADHD and changes in children's microbiota related to cesarean delivery or antibiotic use.

Lower Hypoglycemia Risk, Greater Weight Loss With SGLT2 Inhibitor, Sulfonylurea in T2D

Lower Hypoglycemia Risk, Greater Weight Loss With SGLT2 Inhibitor, Sulfonylurea in T2D

SGLT-2i exhibited superior effects in terms of weight loss and did not increase the risk for hypoglycemia in dual therapy with sulfonylurea.

Corticosteroid Use May Modestly Reduce Mortality Risk in Sepsis

Corticosteroid Use May Modestly Reduce Mortality Risk in Sepsis

The use of corticosteroids in sepsis appears to modestly reduce the risk for death and modestly increase neuromuscular weakness but the evidence is not definitive.

Ribociclib FDA-Approved For Additional Indications in HR+, HER2- Advanced Breast Cancer

Ribociclib FDA-Approved For Additional Indications in HR+, HER2- Advanced Breast Cancer

The FDA based its approval on the results of a triplet of phase 3 studies, the MONALEESA-2, MONALEESA-3, and MONALEESA-7.

Erythematous Lesions on the Arm and Chest

In Case 1, a 24-year-old woman presents to the clinic with a 4-month history of an erythematous annular lesion on the dorsal arm. In Case 2, a 47-year-old non-Hispanic white woman presents to the clinic with a history of a chest lesion for several years. Can you diagnose these conditions?

PUFAs Inversely Associated With Asthma in Preschool Children

PUFAs Inversely Associated With Asthma in Preschool Children

Total omega-3 and omega-6 plasma polyunsaturated fatty acids relative abundances were significantly inversely correlated with asthma/recurrent wheeze and allergic sensitization.

High Population Immunity Aids in Global Elimination of Sabin-2 Poliovirus

High Population Immunity Aids in Global Elimination of Sabin-2 Poliovirus

High population immunity is an indicator of the decline in serotype 2 Sabin vaccine poliovirus after serotype 2 oral poliovirus vaccine withdrawal.

Tucatinib May Be A Safe, Novel Treatment for ERBB2/HER2-Positive Breast Cancer

Tucatinib May Be A Safe, Novel Treatment for ERBB2/HER2-Positive Breast Cancer

For this phase 1b study, researchers enrolled 57 patients with ERBB2/HER2-positive metastatic breast cancer previously treated with trastuzumab and a taxane.

5 Tips to Negotiate a Better Job Offer

5 Tips to Negotiate a Better Job Offer

Before you sign on the dotted line, take these steps to ensure you are compensated fairly.

Knowledge, Confidence Barriers Hinder Effective Management of Vulvovaginal Atrophy

Knowledge, Confidence Barriers Hinder Effective Management of Vulvovaginal Atrophy

Researchers created a 3-part online survey to assess the knowledge, attitudes, and barriers of primary care providers and gynecologists regarding vulvovaginal atrophy.

Smoking Promotes Disease Progression in Multiple Sclerosis

Smoking Promotes Disease Progression in Multiple Sclerosis

Investigators examined the effects of smoking on respiratory symptoms and functional levels in patients with multiple sclerosis.

Selective Serotonin Reuptake Inhibitors May Increase Risk for Suboptimal Fetal Growth

Selective Serotonin Reuptake Inhibitors May Increase Risk for Suboptimal Fetal Growth

Use of serotonin reuptake inhibitors for maternal depression may increase the risk for low birth weight in children.

Prenatal Insecticide Exposure in Mother May Be Linked to Risk for Autism in Children

Prenatal Insecticide Exposure in Mother May Be Linked to Risk for Autism in Children

Levels of p,p'-DDE were higher in mothers of children with autism than in mothers of children in the control group.

Effect of Folic Acid Supplementation on Pre-Eclampsia Prevention in High-Risk Patients

Effect of Folic Acid Supplementation on Pre-Eclampsia Prevention in High-Risk Patients

High-dose folic acid supplementation beyond the first trimester does not prevent pre-eclampsia in high-risk women.

Including Hypertensive Disorders of Pregnancy in CVD Risk Score Does Not Improve CVD Risk Prediction

Including Hypertensive Disorders of Pregnancy in CVD Risk Score Does Not Improve CVD Risk Prediction

Adding history of hypertensive disorders of pregnancy to the current cardiovascular disease (CVD) risk score does not improve CVD prediction in low-risk women.

Physical Activity as a Lifestyle Factor Influencing Early Menopause

Physical Activity as a Lifestyle Factor Influencing Early Menopause

Researchers concluded that physical activity was not associated with risk for early menopause.

Brivaracetam Effective for Reducing Seizures in Patients with Epileptic Encephalopathies

Brivaracetam Effective for Reducing Seizures in Patients with Epileptic Encephalopathies

Although 2 patients experienced an increase in seizure frequency, the remaining patients did not experience a change in frequency.

Poor Glycemic Control Associated With Higher Risk for Dementia in Older Adults With T1D

Poor Glycemic Control Associated With Higher Risk for Dementia in Older Adults With T1D

Repeated exposure to high levels of HbA1c was associated with increased risk for dementia in a cohort of patients age ≥50 with type 1 diabetes.

Cesarean Delivery Linked to Food Allergy in Offspring

Cesarean Delivery Linked to Food Allergy in Offspring

Children born by cesarean delivery who were large for gestational age and had low Apgar scores may be at increased risk of developing a food allergy.

Relationship Between Atopic Disorders May Be Age Dependent

Relationship Between Atopic Disorders May Be Age Dependent

Although allergic sensitization and hay fever rates increased as children grew older, the rates of asthma dropped.

Intensive Blood Pressure Therapy Lowers Cardiovascular Risk in Diabetes

Intensive Blood Pressure Therapy Lowers Cardiovascular Risk in Diabetes

Intensive blood pressure therapy is associated with a significantly lower risk for serious cardiovascular events in the adults with diabetes.

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