Allergy & Immunology News Archive

Oral Food Challenge Failures Frequent in Patients With Atopic Dermatitis

Investigators examined whether excessive food allergy testing in patients with atopic dermatitis might lead to food intolerance when certain foods are removed from the diet.

Omalizumab Shows Promise as Rescue Therapy in Status Asthmaticus

Omalizumab rescue therapy produced rapid results in a patient with refractory status asthmaticus.

Pregnant Women Commonly Refuse Vaccines

Providers believe stressing fetal protection is most effective strategy against refusal.

Does Gestational Age at Birth Impact Seizure Risk Following Receipt of Measles Vaccine?

The study utilized the Vaccine Safety Datalink and included children who received the first dose of a measles-containing vaccine between 12 and 23 months old during the study period of January 1, 2003 to September 20, 2015.

Oral Immunomodulatory Therapy for Pediatric Peanut Allergy

Pediatric patients with peanut allergy may benefit from an oral immunomodulatory treatment that can reduce the severity of symptoms associated with peanut protein ingestion.

Lanadelumab Reduces Attack Rate in Hereditary Angioedema

Significant reduction in attack rate compared with placebo seen for 3 dose regimens of lanadelumab.

ACAAI: Almost 2% of Children Have Milk Allergy

Among children with food allergy, 53% of infants have milk allergy vs 15% of teens.

Herpes Zoster Recombinant Vaccine Seems Most Effective

However, adjuvant recombinant subunit vaccine tied to more injection site adverse events.

Influenza Vaccines May Protect Against Lab-Confirmed Influenza-Linked Hospitalization During Pregnancy

For women who are pregnant, influenza vaccines may moderately protect against laboratory-confirmed influenza-associated hospitalization.

Prevalence of Atopic Dermatitis 7.3% in U.S. Adults

The prevalence of atopic dermatitis is 7.3% among US adults, and patients with atopic dermatitis and more severe disease have worse quality of life.

Tdap Vaccine Can Be Administered as a Decennial Booster Dose

A second dose of Tdap, a reduced-antigen-content tetanus-diphtheria-acellular pertussis vaccine, 9 years after initial vaccination was well tolerated and immunogenic.

Oral Immunotherapy Beneficial in Patients With Wheat Allergy

Vital wheat gluten oral immunotherapy induces desensitization in about half of patients with wheat allergy after a year of treatment.

Prior-Season Vaccination Not Associated With Flu Shot Effectiveness

Prior-season vaccination is not associated with reduced vaccine effectiveness among children aged 2 to 17 years.

Health Officers Express Concerns About Vaccine Exemptions

Health officers and immunization staff reported concerns including an increase in medical exemptions.

Influenza Vaccination Rates Vary as Clinic Day Progress

Research results indicated vaccination rates declined as clinic day progressed and that active choice intervention was linked with increased vaccinations.

BLA for Novel Peanut Allergy Treatment Submitted to FDA

Viaskin Peanut, an epicutaneous immunotherapy (EPIT), delivers small amounts of peanut protein through a wearable patch to induce desensitization.

Gap Found in Pneumoccal Vaccine Recommendations Among Primary Care Clinicians

While primary care physicians overwhelmingly recommend pneumococcal vaccines, there is a gap in their knowledge of how to implement related vaccine recommendations.

Postnatal Education Increases Pain Relief Interventions at Vaccinations

In-hospital postnatal education about infant pain management at vaccinations leads to more frequent use of pain relief interventions

Third Trimester Immunization With Tdap Vaccine Optimal for Pertussis Toxin Antibody Concentrations in Newborns

Immunization with Tdap vaccine during the third trimester of pregnancy resulted in higher concentrations of pertussis toxin antibodies in newborns.

Pneumococcal H Influenzae Protein D Conjugate Vaccine Effective in Children

The burden of childhood and infant pneumonia can be effectively reduced through the use of the pneumococcal Haemophilus influenzae protein D conjugate vaccine.

Gardasil 9 Approved for Use in Women and Men 27 Through 45 Years Old

The approval of the expanded age range was based on data from a clinical trial which evaluated the efficacy of Gardasil (quadrivalent human papillomavirus recombinant vaccine) in 3253 women 27-45 years of age with a median duration of follow-up of 3.5 years post-dose 3.

More Than 14 Million Preteens Need to Receive HPV Vaccine

14 million need to receive two doses of vaccine to reach goal of 80% vaccination by 2026.

Variations in Influenza Vaccination Coverage Among Healthcare Employees Reported

Wide variations in influenza vaccine coverage have been noted across healthcare personnel based on occupation and worksite.

Active Choice Intervention Effective in Increasing Influenza Vaccination Rates at Primary Care Practices

Influenza vaccination rates decline as the clinic day progresses.

Delabeling Patients as Beta-Lactam Allergic Requires Record Updates

Changes in allergy records were suggested by the allergy service consult for 62% of the patients.

Additional Symjepi Dosage Strength Approved for Anaphylaxis Treatment

Both doses will be supplied in single-dose, prefilled syringes for manual injection.

Improved Documentation May Help Distinguish Beta-Lactam Allergy vs Intolerance

A documented β -lactam allergy was found in more than one-third of patients receiving broad-spectrum antibiotics, however, only 10% of patients were found to be truly allergic.

Monovalent Acellular Pertussis Vaccine Safe and Effective for Neonates With Mothers Unvaccinated for Tdap

The monovalent acellular pertussis vaccine may be beneficial to neonates whose mothers did not receive Tdap vaccine during pregnancy.

HPV Vaccination Decreases High-Grade Cervical Lesions in Women

From 2008 to 2015, both cervical intraepithelial neoplasia grades 2, 3 and adenocarcinoma in situ rates and cervical cancer screening declined in women age 18 to 24 years.

Pest Allergies in Urban Adolescents Exacerbate Poorly Controlled Asthma

Cockroach and mouse allergies were most often associated with poorly controlled asthma and exacerbations in urban adolescents.

Allergy, But Not Asthma, Risk Increased in Children of East Asian Descent

Children of East Asian-born parents had an increased risk for allergic rhinitis and aeroallergen sensitization compared with children of Caucasian ancestry.

High Population Immunity Aids in Global Elimination of Sabin-2 Poliovirus

High population immunity is an indicator of the decline in serotype 2 Sabin vaccine poliovirus after serotype 2 oral poliovirus vaccine withdrawal.

Cesarean Delivery Linked to Food Allergy in Offspring

Children born by cesarean delivery who were large for gestational age and had low Apgar scores may be at increased risk of developing a food allergy.

Relationship Between Atopic Disorders May Be Age Dependent

Although allergic sensitization and hay fever rates increased as children grew older, the rates of asthma dropped.

Penicillin Allergies: Commonly Reported but Rarely Accurate

As infections from drug-resistant microbes continue to rise, the development of new antibiotics has declined since the golden age of antibiotic discovery in the mid-20th century.

Walgreens to Offer Auvi-Q Nationwide in an Effort to Address Epinephrine Supply Issues

This effort is in response to epinephrine auto-injector supply issues reported by manufacturers to the Food and Drug Administration (FDA).

Addition of High-Dose Guaifenesin Benefits Patient With Chronic Respiratory Conditions

According to the report, the patient complained of a non-productive cough, accumulation of mucus, and post-nasal drip and requested a thorough assessment of her medical conditions.

Prenatal Tdap Vaccination Not Associated With an Increased Risk of Autism

No association was observed between prenatal vaccination of Tdap vaccination and an increased risk of autism spectrum disorder risk in children.

AAP Updates Recommendations for Pediatric Flu Vaccination

All children age 6 months and older, including teens, advised to undergo annual immunization.

Fostamatinib Seems Effective for Immune Thrombocytopenia

Overall response of platelet count 50,000/L seen in 43% of patients.

China Withholding H7N9 Bird Flu Virus Samples From US

Specimens of the rapidly evolving virus are needed to develop vaccines and treatments.

Serogroup B Meningococcal Vaccine, Disease Knowledge Gaps Apparent in Primary Care

Due to a gap in knowledge regarding serogroup B meningococcal (MenB) disease and vaccination, the majority of clinicians are not discussing MenB vaccines with their adolescent patients during routine visits.

CDC: Updated Influenza Vaccination Recommendations for 2018-2019

In general, routine annual vaccination is recommended for all patients ≥6 months of age who have no contraindications.

Novel Malaria Vaccine Shows Activity Only at Peak Titers

A malaria transmission-blocking vaccine, Pfs25H-EPA in Alhydrogel®, was well tolerated and safe and induced significant blockage of parasite transmission, but this activity was only seen at peak titers after 4 vaccine doses.

How to Tell Your Anti-Vaccine Patients the Truth About Vaccines

What's the best way to tell your anti-vaccine patients the truth about vaccines?

Parental Influences on HPV Vaccination Among Low-Income Hispanic Adolescent Girls

Researchers sought to identify parental predictors of HIV vaccination in low-income adolescent Hispanic girls.

First Generic Version of EpiPen Gets FDA Approval

Unlike other generic approvals, epinephrine auto-injectors are considered "combination products" because they consist of both a drug and a device, making the approval process more challenging.

Safety and Immunogenicity of Tdap Vaccine Immunization During Pregnancy

Immunization with Tdap vaccine during pregnancy results in higher levels of antibodies early in infancy but lower levels after the primary vaccine series.

Vaccinations Begin in Congo Ebola Outbreak

First to be vaccinated will be health workers, contacts of confirmed Ebola patients.

Food Allergies Linked to Reduced Small Airway Function in Children With Asthma

Children and young adults with asthma and multiple food allergies may be at risk for reduced small airway lung function than children with a single food allergy.

Atopic Dermatitis Associated With Impaired Quality of Life, Overall Health

Research shows that patients diagnosed with atopic dermatitis experience feelings of dissatisfaction with regard to lifestyle, as well as impaired health and wellness.

Severe Asthma Risk Increased From Aspergillus fumigatus Sensitization

Sensitization to Aspergillus fumigatus increased the risk for severe asthma.

Daily BCX7353 Cuts Rate of Hereditary Angioedema Attacks

Oral administration of BCX7353 at dose of 125 mg results in lower rate of attacks vs placebo.

Combined Meningococcal-Tdap Vaccine May Increase Adolescent Vaccination Coverage

For adolescents and young adults, the co-administration of quadrivalent meningococcal conjugate vaccine with incorporated tetanus toxoid with diphtheria-tetanus-acellular pertussis vaccine is noninferior to isolated vaccination and does not compromise immunity.

Asthma Hospitalization Risk in Children From Grass, Weed, and Other Pollens

Grass, other weeds, and unclassified pollen were significantly associated with increased risk for asthma hospitalization in young children.

Rotavirus Vaccination Linked to Decrease in Hospitalizations

A significant decline in rotavirus disease-associated hospitalization, emergency department visits, and physician office visits was demonstrated in children younger than 5 years following implementation of the rotavirus vaccine.

Inactivated Influenza Vaccine Preferred for Nursing Mothers

Women receiving the inactivated influenza vaccine demonstrated superior antibody response compared with those receiving the live attenuated influenza vaccine.

HPV Vaccine Eliminates Advanced Skin Cancer in 97-Year-Old

Less than a year following the initial direct-to-tumor vaccine injection, all treated tumors disappeared.

HPV Vaccine Failure Rates May Be Higher in Women, Girls With HIV

Vaccinated women and girls living with HIV may be at greater risk for HPV vaccine failure compared with women and girls without HIV.

Lack of Vaccination in High-Exempt Areas Linked to Medical Distrust

Exemption from vaccination is common in Arizona school districts due to lack of trust in medical establishments.

Food-Induced Anaphylaxis Risk in Infants, Children

Respiratory symptoms were more common in older children compared with infants who presented with food-induced anaphylaxis.

Public Health Vaccine Opposition Growing in the United States

Inverse association identified between NME rate and MMR vaccine coverage of kindergarteners.

Otitis Media-Related Ambulatory Visits Declined After Pneumococcal Conjugate Vaccine

The administration of PCV7 and PCV13 reduced the number of ambulatory visits for otitis media in pediatric patients.

Tick-Caused Meat Allergy on the Rise in the United States

Lone star tick is most common in the South, but may be spreading to new areas

Universal Purchase Programs in the United States May Not Effectively Increase Vaccination Rates

Using state- and individual-level data from the 1995-2014 National Immunization Survey, the effect of a state's Universal Purchase adoption on vaccination rates was estimated.

New AAP Policy on Patient Dismissal for Vaccine Refusal May "Erode Solidarity" Among Pediatricians

Others have argued that dismissal is ethically problematic because it can deprive children of comprehensive pediatric care and undermine public health.

Poor Adherence Contributes to Inadequate Uptake of Multidose Hepatitis Vaccine Schedules

Adherence and completion to multidose vaccine schedules for hepatitis A, B, and A-B are low, thereby rendering vaccination ineffective.

Demographic Insights Into Hepatitis Vaccination Practices

From 2007 to 2015, the majority of initial hepatitis A, B, and A/B vaccinations were administered by primary care providers.

CDC Surveillance Information for the 2017-2018 Influenza Season in the United States

The 2017-2018 influenza season in the United States (October 1, 2017-May 19, 2018) was a high-severity season.

BCG Vaccine Tied to Reduced Hyperglycemia in Type 1 Diabetes

Systemic shift in glucose metabolism from oxidative phosphorylation to aerobic glycolysis.

No Association Between Rotavirus Vaccination and Intussusception in New Study

The risk of intussusception within 1 to 7 days and 8 to 21 days after rotavirus vaccination was assessed in infants age 28 to 245 days.

CD63 Ratio May Predict Allergic Reaction Severity in Peanut Food Challenge

Researchers developed a predictive algorithm to identify individuals with a higher risk for severe reactions to the standardized peanut oral food challenge.

Vaccination of Auto-HSCT Patients May Reduce the Risk of Herpes Zoster Diagnosis

Early vaccination of autologous hemopoietic stem-cell transplant (auto-HSCT) recipients during the peri-transplant period can be effective for the prevention of infections such as herpes zoster.

Some Common Allergies Linked to Odds of Autism in Children

Significant, positive link for common allergies, especially food allergy, with autism

Varicella Zoster Vaccine Effective for Hematopoietic Stem Cell Transplant Recipients

In a phase 3 clinical trial, early vaccination effectively prevented herpes zoster in auto-HSCT recipients.

CDC: Administration Errors Reported With New Shingles Vaccine

Between October 20, 2017 and February 20, 2018, the Vaccine Adverse Event Reporting System (VAERS) received 155 reports involving RZV, with 13 (8%) involving an administrative error.

Is Current Hib Vaccine Effectiveness Decreasing in Children?

The hexavalent DTPa-HBV-IPV/Hib vaccine may not affect Hib vaccine efficacy.

CDC: Get Vaccinated for Measles Before Traveling

The CDC recommends 2 doses of the MMR vaccine, which provides 97% protection against measles, prior to international travel.

Robust Immune Responses for Herpes Zoster Subunit Vaccine

Humoral response seen for 97.8% of HZ/su vaccine recipients vs 2% of placebo

Good Evidence That HPV Vaccines Protect Against Cervical Precancer

High-certainty evidence for protection in adolescent girls and young women aged 15 to 26 years

Seasonal Allergies: Treatment Tips From the FDA

The US Food & Drug Administration (FDA) has released updated tips for the treatment of seasonal allergies.

Personalized Cancer Vaccine Looks Promising in Early Study

The researchers enrolled 25 platinum-pretreated, immunotherapy-naïve patients with recurrent advanced epithelial ovarian cancer (EOC) for the trial.

ACOG: Updated Recommendations for Influenza Vaccination During Pregnancy

This updated Committee Opinion includes more recent data on the safety and efficacy of influenza vaccination during pregnancy, as well as recommendations for treatment and postexposure chemoprophylaxis.

Birch Pollen-Related Foods Can Trigger Dermatitis Reactions

Intake may lead to aggravation of symptoms in patients with atopic dermatitis, birch pollen allergy

Infant Use of Acid-Suppressants, Antibiotics Tied to Allergic Disease Development

Some allergic diseases associated with acid-suppressive, antibiotic intake in infants younger than 6 months old include food allergies, anaphylaxis, asthma, and allergic rhinitis.

Maternal Probiotic, Fish Oil Intake Linked to Offspring Immune Development

Maternal diet may be correlated with certain autoimmune-associated diseases in offspring.

Maternal TDF not effective in reducing hepatitis B transmission

TDF did not reduce mother-to-child HBV transmission in mothers taking hepatitis B Ig and HBV vaccine.

Clinician HPV interventions facilitate adolescent HPV vaccination

Clinicians using communication training and fact sheets to inform adolescents about HPV, significantly increased vaccination initiation and completion rates among their patients.

Newer HIV testing options underused in Black MSM and transgender women

Increasing awareness of and access to newer HIV testing options such as free or reduced price on home and self-tests and couples HIV testing and counseling can facilitate increased levels of consistent testing among young, Black MSM, and transgender women.

Seasonal SCIT dose adjustments fail to reduce systemic reactions in pediatric patients

Researchers sought to assess the effect of seasonal dose adjustments on the rate of systemic reactions in pediatric patients receiving standardized allergen subcutaneous immunotherapy.

Allergic response in patients with chronic rhinosinusitis and nasal polyposis

Researchers assessed the use of dupilumab in adults with chronic rhinosinusitis and nasal polyps who did not respond to treatment with intranasal corticosteroids.

CDC: Influenza vaccine 25% effective against H3N2 in 2017-2018

The 2017 to 2018 influenza vaccine reduces the chance of getting the disease by about 33%, but is only 25% effective against H3N2, otherwise known as influenza A.

ACIP releases 2018 recommended immunization schedule for adults

The Advisory Committee on Immunization Practices updated its immunization recommendations for adults.

2018 Immunization schedule for children, adolescents: ACIP recommendations

The updates contain new or revised ACIP recommendations for poliovirus, influenza, and measles, mumps, and rubella vaccines, as well as a clarification of the recommendations for rotavirus and pneumococcal vaccines.

Herpes zoster subunit vaccine more effective, less expensive than live attenuated herpes zoster vaccine

The adjuvanted herpes zoster subunit vaccine is more effective and less expensive than the live attenuated herpes zoster vaccine at all ages.

Provider-demanded flu testing less likely in elderly patients

Younger adults are more likely to have provider-ordered flu testing than older adults.

Multiple flu vaccinations may prevent death, serious infection

Intensive care and death were greatly prevented in patients who were annually vaccinated.

Flu vaccine safe for individuals with egg allergy

Inactivated and live attenuated flu vaccines can be safely administered to people with egg allergies.

Children are exposed to more allergens in daycare than at home

Day-care centers have more allergens from pets and mites than in homes.

Healthcare system fires 50 employees for refusing influenza vaccination

A Minnesota-based hospital chain fires about 50 employees for refusal to receive the influenza vaccine.

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