Allergy & Immunology News Archive

Severe Asthma Risk Increased From Aspergillus fumigatus Sensitization

Sensitization to Aspergillus fumigatus increased the risk for severe asthma.

Daily BCX7353 Cuts Rate of Hereditary Angioedema Attacks

Oral administration of BCX7353 at dose of 125 mg results in lower rate of attacks vs placebo.

Combined Meningococcal-Tdap Vaccine May Increase Adolescent Vaccination Coverage

For adolescents and young adults, the co-administration of quadrivalent meningococcal conjugate vaccine with incorporated tetanus toxoid with diphtheria-tetanus-acellular pertussis vaccine is noninferior to isolated vaccination and does not compromise immunity.

Asthma Hospitalization Risk in Children From Grass, Weed, and Other Pollens

Grass, other weeds, and unclassified pollen were significantly associated with increased risk for asthma hospitalization in young children.

Rotavirus Vaccination Linked to Decrease in Hospitalizations

A significant decline in rotavirus disease-associated hospitalization, emergency department visits, and physician office visits was demonstrated in children younger than 5 years following implementation of the rotavirus vaccine.

Inactivated Influenza Vaccine Preferred for Nursing Mothers

Women receiving the inactivated influenza vaccine demonstrated superior antibody response compared with those receiving the live attenuated influenza vaccine.

HPV Vaccine Eliminates Advanced Skin Cancer in 97-Year-Old

Less than a year following the initial direct-to-tumor vaccine injection, all treated tumors disappeared.

HPV Vaccine Failure Rates May Be Higher in Women, Girls With HIV

Vaccinated women and girls living with HIV may be at greater risk for HPV vaccine failure compared with women and girls without HIV.

Lack of Vaccination in High-Exempt Areas Linked to Medical Distrust

Exemption from vaccination is common in Arizona school districts due to lack of trust in medical establishments.

Food-Induced Anaphylaxis Risk in Infants, Children

Respiratory symptoms were more common in older children compared with infants who presented with food-induced anaphylaxis.

Public Health Vaccine Opposition Growing in the United States

Inverse association identified between NME rate and MMR vaccine coverage of kindergarteners.

Otitis Media-Related Ambulatory Visits Declined After Pneumococcal Conjugate Vaccine

The administration of PCV7 and PCV13 reduced the number of ambulatory visits for otitis media in pediatric patients.

Tick-Caused Meat Allergy on the Rise in the United States

Lone star tick is most common in the South, but may be spreading to new areas

Universal Purchase Programs in the United States May Not Effectively Increase Vaccination Rates

Using state- and individual-level data from the 1995-2014 National Immunization Survey, the effect of a state's Universal Purchase adoption on vaccination rates was estimated.

New AAP Policy on Patient Dismissal for Vaccine Refusal May "Erode Solidarity" Among Pediatricians

Others have argued that dismissal is ethically problematic because it can deprive children of comprehensive pediatric care and undermine public health.

Poor Adherence Contributes to Inadequate Uptake of Multidose Hepatitis Vaccine Schedules

Adherence and completion to multidose vaccine schedules for hepatitis A, B, and A-B are low, thereby rendering vaccination ineffective.

Demographic Insights Into Hepatitis Vaccination Practices

From 2007 to 2015, the majority of initial hepatitis A, B, and A/B vaccinations were administered by primary care providers.

CDC Surveillance Information for the 2017-2018 Influenza Season in the United States

The 2017-2018 influenza season in the United States (October 1, 2017-May 19, 2018) was a high-severity season.

BCG Vaccine Tied to Reduced Hyperglycemia in Type 1 Diabetes

Systemic shift in glucose metabolism from oxidative phosphorylation to aerobic glycolysis.

No Association Between Rotavirus Vaccination and Intussusception in New Study

The risk of intussusception within 1 to 7 days and 8 to 21 days after rotavirus vaccination was assessed in infants age 28 to 245 days.

CD63 Ratio May Predict Allergic Reaction Severity in Peanut Food Challenge

Researchers developed a predictive algorithm to identify individuals with a higher risk for severe reactions to the standardized peanut oral food challenge.

Vaccination of Auto-HSCT Patients May Reduce the Risk of Herpes Zoster Diagnosis

Early vaccination of autologous hemopoietic stem-cell transplant (auto-HSCT) recipients during the peri-transplant period can be effective for the prevention of infections such as herpes zoster.

Some Common Allergies Linked to Odds of Autism in Children

Significant, positive link for common allergies, especially food allergy, with autism

Is Current Hib Vaccine Effectiveness Decreasing in Children?

The hexavalent DTPa-HBV-IPV/Hib vaccine may not affect Hib vaccine efficacy.

CDC: Get Vaccinated for Measles Before Traveling

The CDC recommends 2 doses of the MMR vaccine, which provides 97% protection against measles, prior to international travel.

Good Evidence That HPV Vaccines Protect Against Cervical Precancer

High-certainty evidence for protection in adolescent girls and young women aged 15 to 26 years

Seasonal Allergies: Treatment Tips From the FDA

The US Food & Drug Administration (FDA) has released updated tips for the treatment of seasonal allergies.

Personalized Cancer Vaccine Looks Promising in Early Study

The researchers enrolled 25 platinum-pretreated, immunotherapy-naïve patients with recurrent advanced epithelial ovarian cancer (EOC) for the trial.

ACOG: Updated Recommendations for Influenza Vaccination During Pregnancy

This updated Committee Opinion includes more recent data on the safety and efficacy of influenza vaccination during pregnancy, as well as recommendations for treatment and postexposure chemoprophylaxis.

Birch Pollen-Related Foods Can Trigger Dermatitis Reactions

Intake may lead to aggravation of symptoms in patients with atopic dermatitis, birch pollen allergy

Infant Use of Acid-Suppressants, Antibiotics Tied to Allergic Disease Development

Some allergic diseases associated with acid-suppressive, antibiotic intake in infants younger than 6 months old include food allergies, anaphylaxis, asthma, and allergic rhinitis.

Maternal Probiotic, Fish Oil Intake Linked to Offspring Immune Development

Maternal diet may be correlated with certain autoimmune-associated diseases in offspring.

Maternal TDF not effective in reducing hepatitis B transmission

TDF did not reduce mother-to-child HBV transmission in mothers taking hepatitis B Ig and HBV vaccine.

Clinician HPV interventions facilitate adolescent HPV vaccination

Clinicians using communication training and fact sheets to inform adolescents about HPV, significantly increased vaccination initiation and completion rates among their patients.

Newer HIV testing options underused in Black MSM and transgender women

Increasing awareness of and access to newer HIV testing options such as free or reduced price on home and self-tests and couples HIV testing and counseling can facilitate increased levels of consistent testing among young, Black MSM, and transgender women.

Seasonal SCIT dose adjustments fail to reduce systemic reactions in pediatric patients

Researchers sought to assess the effect of seasonal dose adjustments on the rate of systemic reactions in pediatric patients receiving standardized allergen subcutaneous immunotherapy.

Allergic response in patients with chronic rhinosinusitis and nasal polyposis

Researchers assessed the use of dupilumab in adults with chronic rhinosinusitis and nasal polyps who did not respond to treatment with intranasal corticosteroids.

CDC: Influenza vaccine 25% effective against H3N2 in 2017-2018

The 2017 to 2018 influenza vaccine reduces the chance of getting the disease by about 33%, but is only 25% effective against H3N2, otherwise known as influenza A.

ACIP releases 2018 recommended immunization schedule for adults

The Advisory Committee on Immunization Practices updated its immunization recommendations for adults.

2018 Immunization schedule for children, adolescents: ACIP recommendations

The updates contain new or revised ACIP recommendations for poliovirus, influenza, and measles, mumps, and rubella vaccines, as well as a clarification of the recommendations for rotavirus and pneumococcal vaccines.

Herpes zoster subunit vaccine more effective, less expensive than live attenuated herpes zoster vaccine

The adjuvanted herpes zoster subunit vaccine is more effective and less expensive than the live attenuated herpes zoster vaccine at all ages.

Provider-demanded flu testing less likely in elderly patients

Younger adults are more likely to have provider-ordered flu testing than older adults.

Multiple flu vaccinations may prevent death, serious infection

Intensive care and death were greatly prevented in patients who were annually vaccinated.

Flu vaccine safe for individuals with egg allergy

Inactivated and live attenuated flu vaccines can be safely administered to people with egg allergies.

Children are exposed to more allergens in daycare than at home

Day-care centers have more allergens from pets and mites than in homes.

Healthcare system fires 50 employees for refusing influenza vaccination

A Minnesota-based hospital chain fires about 50 employees for refusal to receive the influenza vaccine.

FDA approves Heplisav-B vaccine for hepatitis B treatment

The Food and Drug Administration (FDA) has approved Heplisav-B for the prevention of infection caused by all known subtypes of hepatitis B virus.

Reduced effectiveness of last season's flu vaccine traced to mutation in chicken eggs

New virus mutations make antibody binding difficult as mismatches in vaccines and viruses emerge.

Proposed pneumonia vaccine provides universal pneumococcal disease prevention

A pneumonia vaccine under development provides the most comprehensive coverage to date and alleviates antimicrobial concerns.

Peanut patch produces significant treatment response in patients with allergies

A 250-μg peanut patch produces a significant treatment response in peanut-allergic patients treated for a year.

Vaccination coverage remains above 90% for infants

Infants aged 19-35 months had vaccination rates above 90%.

Fish consumption may trigger food protein-induced enterocolitis syndrome

Fish is an important trigger of food protein-induced enterocolitis syndrome.

CDC committee recommends new shingles vaccine

CDC voted for Shingrix over Zostavax as herpes zoster vaccine of choice

Module created to improve adult vaccination rates

The AMA STEPS Forward module helps health care professionals save time by creating a team-based approach for an adult immunization program.

No evidence that the influenza vaccine causes VTE

In the 1 to 10 days after flu vaccine administration, there was no increased risk for VTE.

Positive mood associated with enhanced responses to influenza vaccination

Greater positive mood significantly predicted greater antibody responses to the influenza vaccination.

Tdap vaccination during pregnancy protects infants from pertussis

With a continuing resurgence in pertussis, efforts should focus on maximizing Tdap uptake among pregnant women.

Half of adults with work-related asthma receive pneumococcal vaccination

The researchers found that 42% of the estimated 12 million ever-employed adults with current asthma had received a pneumococcal vaccine.

CDC releases updated influenza vaccine recommendations for 2017-2018

The Advisory Committee on Immunization Practices has released the guidelines for the 2017-2018 season.

AAP: Hepatitis B vaccine should be given within first 24 hours of life

The American Academy of Pediatrics recommends that the first dose of the hepatitis B vaccine should be given within the first 24 hours of life.

Anti-vaccine information during pregnancy could delay infant immunization

Information about vaccines received during pregnancy could influence infant immunization.

Live attenuated influenza vaccine ineffective in children during 2015-2016 season

The live attenuated vaccine was ineffective among children between 2 and 17 years of age during the 2015-2016 season.

Previous maternal influenza vaccine does not weaken newborn benefit

Researchers found that in a cohort of pregnant women, receipt of influenza vaccine the previous year predicts higher baseline antibody titers and decreased peak antibody responses against all influenza strains.

12.9 million infants worldwide not vaccinated in 2016: A WHO report

Nearly 1 in 10 infants did not receive any vaccinations in 2016, according to the World Health Organization.

CDC urges measles vaccine for European travelers

Most measles cases in the United States are the result of international travel.

Bee stings and allergies: prevention and treatment tips

Symptoms of an allergic reaction to an insect sting may include itching and hives, swelling in the throat or tongue, difficulty breathing, dizziness, stomach cramps, nausea, or diarrhea.

Clinician communication affects parental decision-making with pediatric influenza vaccine

About half of patients accepted influenza vaccination for their child if the clinician used a presumptive vs participatory initiation format.

Injectable antiretroviral therapy for as HIV effective as oral medications

The investigators found that after 32 weeks, HIV remained suppressed in 91% percent of those taking the drugs orally, 94% of those receiving monthly injections, and 95% of patients receiving injections every two months.

Many children with suspected penicillin allergy may not be allergic

A 3-part testing process may facilitate increased use of first-line penicillin antibiotics in the pediatric emergency department.

CDC: 101 influenza deaths in children reported for 2016-17

A total of 101 influenza-related deaths occurred among children throughout the 2016-17 flu season.

Hepatitis B vaccine reduces risk of non-Hodgkin lymphoma in adolescents

The universal vaccination against hepatitis B virus infection prevented non-Hodgkin lymphoma in adolescents.

Maternal antibodies inhibit antigenic responses to vaccines in infants

Vaccines given shortly after birth demonstrated a strong inhibitory response to maternal antibodies.

Updated meningococcal vaccine guidelines reflect more dosing options

The Advisory Committee on Immunization Practices released updated guidelines to include recommendations for the 3-dose formulation of serogroup B meningococcal vaccine.

CDC finalizes cholera vaccine recommendation for international travelers

Cholera, an acute, diarrheal illness, is spread by drinking water or eating food that is contaminated with cholera bacteria.

HPV vaccine effective against genital warts in 2 doses

The researchers found that 2 doses of the HPV vaccine were just as protective as 3 doses.

Some EpiPen auto-injectors recalled due to possible defect

Mylan is recalling select lots of EpiPen due to a defect that might render it difficult to activate in an emergency.

2017 Adult immunization schedule released by the CDC

The ACIP has released the 2017 recommended immunization schedule for adults.

One-third of asthma patients may be misdiagnosed

About one-third of adults with physician-diagnosed asthma in the last 5 years may not have a current diagnosis.

NIH releases addendum guidelines to prevent peanut allergies through early introduction

The NIAID has issued addendum guidelines regarding the early introduction of peanut-containing foods to infants at risk for peanut allergies.

Food additives may affect recurrent aphthous stomatitis

Participants underwent patch testing for food in an effort to examine whether food additives play a role in recurrent aphthous stomatitis etiology.

Prenatal fish oil supplementation may reduce asthma risk in children

Supplementation during pregnancy was associated with reduction in risk of persistent wheezing and asthma in offspring.

Higher cured meat intake linked to worsening asthma

Cured meat intake levels also had an indirect effect mediated by body mass index.

FDA bans powdered surgeon's and patient examination gloves

The FDA has issued a final ruling to ban powdered surgeon's gloves, powdered patient examination gloves, and absorbable powder for lubricating a surgeon's glove.

Exposure to mold and dampness may increase risk of asthma and rhinitis

Exposure during infancy was associated with increased risk up to 16 years of age, especially for nonallergic disease.

CDC: Influenza vaccine rate low this season

Forty percent of people have reported receiving the flu vaccine thus far, including 37% of children.

Report outlines strategy to improve food allergy safety in US

The Committee on Food Allergies concluded that the actual prevalence of food allergies is unknown due to misinterpretation of symptoms and lack of simple diagnostic tests.

Early peanut introduction may increase odds of successful oral food challenge

Early introduction increased the probability of a successful oral food challenge.

Primary care providers order more food allergen panels than allergists

Primary care providers also order more tests for uncommon causes of food allergy and generate higher costs.

Edible seeds becoming major food allergens

The inclusion of seeds in food and food products may be a contributing factor in the increase of seed allergies.

Indoor environmental control strategies to manage asthma in children

Strategies include source removal, source control, and asthma education.

Skin patch may help children and teens with peanut allergy

The patch delivers small amounts of peanut protein in the hope of boosting peanut tolerance for kids and teens.

Children with farm exposure have decreased regulatory T cells

Regulatory T cells are decreased with farm exposure and increased among those with asthma.

CDC approves HPV vaccine in 2 doses for preteens

Children younger than 15 may be given 2 HPV vaccine doses instead of 3, and the shots should be spaced at least 6 months apart.

Identifying patients at risk of life-threatening allergic reactions to food

Researchers examine factors that could help clinicians identify patients with the highest risk of fatal anaphylaxis.

Allergic sensitization is common in pediatric asthma

Children were assessed for allergic sensitization by two microarray system. As a result, 47% of children had allergic sensitization.

Introducing allergens at an early age may help prevent food allergies

Introducing foods like eggs and peanuts to babies may decrease their chance of developing allergies later in life.

Addressing parental vaccine concerns: AAP provides guidance for clinicians

The AAP has released a report to help clinicians address the concerns of parents who are hesitant about their children's vaccination.

Mumps outbreak controlled by third dose of MMR vaccine

A third dose of the MMR vaccine should be administered in cases of a mumps outbreak.

Concomitant vaccine administration may increase febrile seizure risk

Children who receive the influenza vaccine at the same time as PCV or a DTaP-containing vaccine have an increased risk for febrile seizure.

Predicting viral mutations may improve flu vaccine efficacy

Natural viral mutations ensure that the seasonal flu vaccine must be updated on a yearly basis.

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