Alzheimer's Disease & Dementia

Retinal Nerve Fiber Layer Thickness May Be Associated With Cognitive Function

Retinal Nerve Fiber Layer Thickness May Be Associated With Cognitive Function

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Thinning of the retinal nerve fiber layer has been linked to worsening cognitive function and may be valuable in identifying individuals who may be at risk for cognitive decline.

Diagnosis, Treatments Affected by Amyloid Results in Dementia, Nondementia Patients

Diagnosis, Treatments Affected by Amyloid Results in Dementia, Nondementia Patients

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In patients with and without dementia, amyloid-positive and negative results were significantly linked to diagnoses and treatment changes.

Genetic Risk Score Better Than APOE Alone for Assessing Risk for Alzheimer's Dementia

Genetic Risk Score Better Than APOE Alone for Assessing Risk for Alzheimer's Dementia

The genetic risk score primarily modified the risk for and onset of dementia and AD among homozygous carriers for APOE ε4.

Dementia, Alzheimer Disease Risk Increased With Lower Branched-Chain Amino Acid Levels

Dementia, Alzheimer Disease Risk Increased With Lower Branched-Chain Amino Acid Levels

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Lower BCAA levels may be associated with an increased risk of incident dementia.

Excessive Daytime Sleepiness Linked to Elevated β-Amyloid Accumulation in Elderly Persons

Excessive Daytime Sleepiness Linked to Elevated β-Amyloid Accumulation in Elderly Persons

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Elderly individuals without dementia who have elevated daytime sleepiness may be at greater risk for β-amyloid accumulation.

Trials for Investigational Alzheimer's Treatment Lanabecestat Discontinued

Trials for Investigational Alzheimer's Treatment Lanabecestat Discontinued

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The independent data monitoring committee (IDMC) concluded that the 2 trials (AMARANTH and DAYBREAK-ALZ) investigating the treatment in mild Alzheimer's disease dementia, were not likely to meet their primary endpoints of change from baseline on the 13-item Alzheimer's Disease Assessment Scale - Cognitive Subscale.

Accumulation of Brain Pathologies Linked to Reduced Activity in Older Adults

Accumulation of Brain Pathologies Linked to Reduced Activity in Older Adults

Brain autopsies of participants of the Rush Memory Aging project (n=428) were studied to identify the association between brain pathologies and total daily physical activity and mortality.

Newly Proposed Definition of Alzheimer's Disease Focuses on Biologic Criteria

Newly Proposed Definition of Alzheimer's Disease Focuses on Biologic Criteria

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The NIA-AA has proposed updates to the 2011 guidelines for symptomatic stages of Alzheimer's disease to include the idea that certain imaging and cerebrospinal fluid biomarkers are valid proxies for neuropathologic changes of AD.

Hip fracture risks increase with short-term PPI use in patients with Alzheimer's disease

Hip fracture risks increase with short-term PPI use in patients with Alzheimer's disease

Short-term proton pump inhibitors (PPIs) are linked to an elevated risk for hip fracture among patients with Alzheimer's disease. No link is seem among patients taking long-term or cumulative PPIs.

Solanezumab does not change cognitive decline in mild Alzheimer’s disease

In patients with mild Alzheimer's disease solanezumab, an antibody designed to facilitate clearance of amyloid-beta plaques, did not significantly reduce cognitive decline over time.

Higher education may help reduce Alzheimer's disease risk

Higher education may help reduce Alzheimer's disease risk

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Attaining higher education may aid in the prevention of Alzheimer's disease.

Alzheimer's cases to increase to 15 million by 2060

Alzheimer's cases to increase to 15 million by 2060

Over 6 million Americans were diagnosed with Alzheimer's this year, which will increase to 15 million by 2060.

Sleep disorders may increase risk for Alzheimer's disease

Sleep disorders may increase risk for Alzheimer's disease

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Obstructive sleep apnea and sleep-disordered breathing are associated with amyloid deposition.

Residing near busy roads increases risk for dementia

Residing near busy roads increases risk for dementia

Approximately 11% of dementia cases for people living within 164 feet of a major roadway might be attributed to this proximity to traffic.

Statins may reduce risk of Alzheimer's disease

Statins may reduce risk of Alzheimer's disease

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Depending on race, sex, and ethnicity, the right statin type may lower the risk of Alzheimer disease.

Risk of Alzheimer dementia after androgen deprivation therapy

Risk of Alzheimer dementia after androgen deprivation therapy

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A recent cohort study evaluated the risk of developing Alzheimer dementia after ADT in 16,888 men with prostate cancer, 14.2% of whom were treated with ADT.

The bravery of people with dementia

The bravery of people with dementia

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Facing dementia with strength and courage can inspire and comfort patients' families.

Minimal benzodiazepine use associated with slightly higher risk of dementia

Minimal benzodiazepine use associated with slightly higher risk of dementia

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Patients administered low doses of benzodiazepines have an elevated risk of dementia and Alzheimer's disease compared with patients who received higher doses.

Prostate cancer treatment linked to Alzheimer's risk

Prostate cancer treatment linked to Alzheimer's risk

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Patients treated with androgen deprivation therapy had a 1.88-times increased rate of developing Alzheimer's disease.

Modifiable risk factors for Alzheimer's disease

Modifiable risk factors for Alzheimer's disease

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Research reveals that focus on diet, mental health, and lifestyle may help lower the number of new cases of Alzheimer's disease.

MIND diet help may lower Alzheimer risk

MIND diet help may lower Alzheimer risk

The MIND diet combines the Mediterranean diet with the DASH diet, both of which call for high consumption of fruits, vegetables, and fish.

Running may lower Alzheimer-related mortality risk

Running may lower Alzheimer-related mortality risk

Patients who ran more than 15.3 miles per week had a 40% reduced risk of dying from Alzheimer disease.

Is a blood test that can predict Alzheimer disease on the way?

Is a blood test that can predict Alzheimer disease on the way?

Researchers have identified 10 proteins in the blood that may be predictors of Alzheimer disease.

Deep brain stimulation may improve memory in Alzheimer's patients

Deep brain stimulation may improve memory in Alzheimer's patients

A pilot study reports deep brain stimulation targeted at the nucleus basalis of Meynert improved or stabilized memory in Alzheimer's patients.

Midlife diabetes, HTN linked to cognitive decline

Midlife diabetes, HTN linked to cognitive decline

Midlife onset of diabetes and hypertension each may contribute to cognitive impairment later in life.

Blood test may predict Alzheimer disease

Blood test may predict Alzheimer disease

Scientists who tested seniors found that the test detected almost all of those who would develop problems.

Celexa cuts Alzheimer's agitation, but safety questionable

Celexa cuts Alzheimer's agitation, but safety questionable

Cognitive and cardiac adverse effects may limit the antidepressant's use for this purpose.

New tests to detect early Alzheimer disease

New tests to detect early Alzheimer disease

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Two new cognitive screening assessment tools appear to be useful additions to the arsenal of Alzheimer testing.

Estradiol, diabetes up dementia risk in women

Estradiol, diabetes up dementia risk in women

Women with both diabetes and elevated estradiol levels were 14 times more likely to develop new-onset dementia.

DDT exposure linked to Alzheimer risk

DDT exposure linked to Alzheimer risk

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Exposure to the banned pesticide DDT may play a role in the development of Alzheimer disease.

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