Generic Name and Formulations:
Flucytosine 250mg, 500mg; caps.
Valeant Pharmaceuticals, Inc
Indications for ANCOBON:
In combination with amphotericin B: Candida infections in septicemia, endocarditis, UTIs and pulmonary infections; cryptococcus infections in meningitis, pulmonary, septicemia, and UTIs.
Adults and Children:
50–150mg/kg per day given in divided doses every 6 hours. To minimize GI upset, give a few capsules at a time over 15 minutes. Renal impairment: give initial dose at lower range.
Renal or hepatic impairment. Monitor electrolytes, blood count, renal and hepatic function before and during therapy. Bone marrow depression (eg, hematologic disease, history or currently treated with radiation or bone marrow depressants). Pregnancy (Cat.C). Nursing mothers.
Antagonized by cytosine arabinoside. May be potentiated by drugs that impair glomerular filtration.
Cardiac events, chest pain, dyspnea, GI upset, abdominal pain, hepatic dysfunction, elevated creatinine and BUN, blood dyscrasias, ataxia, headache, confusion, fatigue, hypoglycemia, hypokalemia, rash, allergic reactions, others.