Antibiotics

Guidance for Antibiotic Use in Patients With Myasthenia Gravis

Guidance for Antibiotic Use in Patients With Myasthenia Gravis

As infection may also lead to worsening symptoms in patients with myasthenia gravis, clinicians must balance prompt and adequate treatment of infection with the risk that some antibiotics can aggravate the condition.

Assessment of Bacterial Vaginosis Screening, Treatment for Prevention of Preterm Delivery

Assessment of Bacterial Vaginosis Screening, Treatment for Prevention of Preterm Delivery

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Treatment with oral clindamycin for pregnant women with bacterial vaginosis in their first trimester does not reduce the risk of late miscarriage or very preterm delivery.

Little Evidence of Gabapentin Efficacy for Off-Label Uses

Little Evidence of Gabapentin Efficacy for Off-Label Uses

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Clinicians who prescribe gabapentin for off-label uses should assess available evidence for a given indication.

OTC Analgesic Use High, Associated With Worse-Than-Expected Clinical Profiles

OTC Analgesic Use High, Associated With Worse-Than-Expected Clinical Profiles

The clinical profiles of patients taking over-the-counter pain medications were found to be poorer than expected, with a high prevalence of migraine headache and many reporting frequent and disabling pain for extended durations.

Antibiotics, Acid Suppressants in Infancy May Up Obesity Risk

Antibiotics, Acid Suppressants in Infancy May Up Obesity Risk

Prescription of antibiotics and acid-suppressing medications in early childhood is associated with an increased risk for obesity.

Probiotics May Reduce Antibiotic Use for Common Acute Infections in Children

Probiotics May Reduce Antibiotic Use for Common Acute Infections in Children

Probiotics provided to reduce the risk for common acute infections may be associated with reduced antibiotic use in infants and children.

Aspirin, Anticoagulants Similarly Prevent VTE After TKA

Aspirin, Anticoagulants Similarly Prevent VTE After TKA

Among patients undergoing total knee arthroplasty, aspirin alone may provide protection against postoperative venous thromboembolism that is similar to that of other anticoagulants.

The Misuse of Antibiotics in Acute Pancreatitis Appears Widespread

The Misuse of Antibiotics in Acute Pancreatitis Appears Widespread

The inappropriate use of antibiotics as prophylaxis and treatment in acute pancreatitis is common, highlighting the efforts required for antibiotic stewardship.

Recurrence of Group B Streptococcal infection similar in shortened and prolonged therapy

The rates of Group B Streptococcal bacteremia recurrence in infants with an initial course of late-onset infection who received shortened and prolonged IV antibiotic therapy were 1.8% and 2.3%, respectively.

Relationships Between Prescribing for UTI, <i>E coli</i> Bacteremia, Resistance

Relationships Between Prescribing for UTI, E coli Bacteremia, Resistance

New data suggest an association between general practitioners' prescribing habits for urinary tract infections and UTI-related E coli bacteremia incidence.

Switching IV to Oral Antibiotics Noninferior for Some Endocarditis Events

Switching IV to Oral Antibiotics Noninferior for Some Endocarditis Events

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For certain patients with endocarditis on the left side of the heart under stable condition, switching from intravenous (IV) antibiotics to orally administered antibiotics is noninferior to staying on IV treatment.

Cesarean Delivery, Early Childhood Antibiotic Use Not Associated With Risk for ADHD

Cesarean Delivery, Early Childhood Antibiotic Use Not Associated With Risk for ADHD

This research rejects any association between increased risk for ADHD and changes in children's microbiota related to cesarean delivery or antibiotic use.

Penicillin Allergies: Commonly Reported but Rarely Accurate

Penicillin Allergies: Commonly Reported but Rarely Accurate

As infections from drug-resistant microbes continue to rise, the development of new antibiotics has declined since the golden age of antibiotic discovery in the mid-20th century.

Pediatric Revisits, Admissions for UTI Similar With Oral or IV Meds

Pediatric Revisits, Admissions for UTI Similar With Oral or IV Meds

Findings support ED discharge with oral antibiotics for children with urinary tract infection.

Completing Sepsis Bundle Within an Hour Cuts Pediatric Mortality

Completing Sepsis Bundle Within an Hour Cuts Pediatric Mortality

However, completing individual bundle elements in that timeframe does not reduce pediatric mortality.

Antibiotics Often Unnecessary for Sacral Pressure Ulcers Complicated by Osteomyelitis

Antibiotics Often Unnecessary for Sacral Pressure Ulcers Complicated by Osteomyelitis

A systematic literature review, published in Clinical Infectious Diseases, found no evidence supporting a benefit to antibacterial therapy for osteomyelitis in patients with stage IV sacral pressure ulcers.

Infective Endocarditis More Common with Valve Issues

Infective Endocarditis More Common with Valve Issues

Antibiotic prophylaxis should be reconsidered with bicuspid aortic valve, mitral valve prolapse.

Novel Antibiotic for <i>C Difficile</i> Infection Gets FDA's QIDP Designation

Novel Antibiotic for C Difficile Infection Gets FDA's QIDP Designation

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ACX-362E is a targeted, narrow spectrum oral antibiotic that blocks the DNA replication process through inhibition of polymerase III, which has been shown to be bactericidal.

Antibiotic-Resistant Bacteria Found in 221 US Healthcare Facilities in 2017

Antibiotic-Resistant Bacteria Found in 221 US Healthcare Facilities in 2017

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Antibiotic resistance is a nationwide issue that affects every state, so how do we combat it?

Oral fluoroquinolone use is linked to increased aortic aneurysm, dissection risks

Oral fluoroquinolone use is linked to increased aortic aneurysm, dissection risks

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Aortic aneurysm risks are significantly elevated in patients taking fluoroquinolone.

Symptomatic treatment inferior to antibiotics in women with UTIs

Symptomatic treatment inferior to antibiotics in women with UTIs

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Treating lower UTIs with diclofenac may help in optimizing antibiotic treatments.

Completing the antibiotic course: Is it necessary?

Completing the antibiotic course: Is it necessary?

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Completing the antibiotic course increases the chance of patients developing antibiotic resistance, according to the authors.

Treatment for cutaneous abscesses

Treatment for cutaneous abscesses

Antibiotics do not always need to be used for cutaneous abscesses, but the condition must be evaluated on a case-by-case basis to make a final decision regarding the appropriate course of treatment for any individual.

Reduced antibiotic prescribing may lead to increase in pneumonia, peritonsillar abscess cases

Reduced antibiotic prescribing may lead to increase in pneumonia, peritonsillar abscess cases

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General practices that prescribe fewer antibiotics may encounter slightly higher incidences of pneumonia and peritonsillar abscess.

Antibiotic use, perceptions differ among patients and providers

Antibiotic use, perceptions differ among patients and providers

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Regarding antibiotic use for upper respiratory infections, patients and providers have different perceptions, behaviors, and knowledge.

One-third of antibiotic prescriptions may be inappropriate, per study by JAMA and CDC

One-third of antibiotic prescriptions may be inappropriate, per study by JAMA and CDC

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Research findings support the need to establish a goal of increased antibiotic stewardship among physicians.

Children with UTIs related to E. coli failing to respond to antibiotics

Children with UTIs related to E. coli failing to respond to antibiotics

Nearly 54% of pediatric UTI cases were resistant to treatment with amoxicillin.

Stat Consult: Acute sinusitis in children and adolescents

Stat Consult: Acute sinusitis in children and adolescents

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Acute sinusitis is common, affecting 6% to 7% of children presenting with respiratory symptoms.

Inappropriate antibiotic prescribing in primary care: the effect of behavioral interventions

Inappropriate antibiotic prescribing in primary care: the effect of behavioral interventions

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In outpatient primary care settings, various behavioral interventions can reduce the rate of inappropriate antibiotic prescribing practices.

CDC, ACP issue guidelines for appropriate antibiotic use for acute respiratory tract infection in adults

CDC, ACP issue guidelines for appropriate antibiotic use for acute respiratory tract infection in adults

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Reducing inappropriate antibiotic prescribing will improve the quality of patient care, decrease healthcare costs, and preserve the effectiveness of antibiotics.

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