IV ceftriaxone no more effective than oral doxycycline for mild Lyme neuroborreliosis
Level 2: Mid-level evidenceThe efficacy of oral doxycycline was compared with that of IV ceftriaxone (Rocephin) in a randomized trial of 118 patients with Lyme neuroborreliosis (Lancet Neurol. 2008;7:690-695). Patients were randomized to oral doxycycline 200 mg plus IV placebo vs. IV ceftriaxone 2 g plus oral placebo once daily for 14 days. Analysis based…