At a Glance Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a mature B-cell lymphoma. It is a type of Hodgkin lymphoma, but it is very different from classical Hodgkin lymphoma. It represents only 5% of Hodgkin lymphomas. It usually affects young adult males. It also usually involves lymph nodes and is more localized (lower stage…
At a Glance Angioimmunoblastic T-cell lymphoma (AITL) is a subtype of peripheral T-cell lymphoma that usually occurs in older adults. Patients typically present with advanced stage lymphoma and are very ill at diagnosis. Lymph nodes are the main site of disease, but liver, spleen, skin, effusions, peripheral blood and bone marrow are commonly affected. What…
At a Glance Marginal zone lymphomas of mucosa-associated lymphoid tissue MALTomas are low-grade small B cell lymphomas that occur in extranodal sites (i.e., the primary site is not lymph node or spleen). They usually occur in adults and are slightly more common in women. The most commonly affected organs are the stomach, intestine, ocular adnexae,…
At a Glance Lymphoplasmacytic lymphoma is a low grade small B-cell non-Hodgkin lymphoma that has a monoclonal B-cell and a monoclonal plasma cell component. Most patients with lymphoplasmacytic lymphoma have Waldenström macroglobulinemia, which is lymphoplasmacytic lymphoma involving the bone marrow and IgM monoclonal gammopathy. It occurs in adults with a median age of 60 at…
At a Glance Mantle cell lymphoma is a small B-cell lymphoma that is clinically more aggressive than other small B-cell non-Hodgkin lymphomas. It commonly presents at a higher stage, including bone marrow and peripheral blood involvement. It is a disease of adults and is more common in men. What Tests Should I Request to Confirm…
