Addison's disease (primary adrenocortical insufficiency)
I. What every physician needs to know. Addison’s disease, or primary adrenocortical insufficiency, is characterized by a deficiency in endogenous cortisol production secondary to destruction or dysfunction of the adrenal cortices. In the United States (US), Addison’s disease is most commonly caused by autoimmune destruction (80% of spontaneous cases), but also has infectious, vascular, metastatic,…
