Ronald Hoffman

All articles by Ronald Hoffman

Primary myelofibrosis/agnogenic myeloid metaplasia

Primary myelofibrosis/agnogenic primary myeloid metaplasia What every physician needs to know: Primary myelofibrosis (PMF) is a chronic malignant hematologic disorder that belongs to the family of Philadelphia chromosome negative myeloproliferative neoplasms. It is characterized by: splenomegaly, a leukoerythroblastic picture on peripheral smear, bone marrow fibrosis, cytopenias, and systemic symptoms. Continue Reading Approximately 60% of patients…

Chronic myelomonocytic leukemia

Chronic myelomonocytic leukemia What every physician needs to know: Chronic myelomonocytic leukemia (CMML) is a clonal stem-cell disorder that has features of both a myelodysplastic syndrome (MDS) and a myeloproliferative neoplasm (MPN) and is thus classified by World Health Organization (WHO) as a mixed MDS/MPN disorder. The typical manifestation of CMML is peripheral blood monocytosis.…

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